scholarly journals Legislating Limits on Human Embryonic Stem Cell Research

2003 ◽  
Vol 3 ◽  
Author(s):  
Sïna A. Muscati
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Embryonic Stem Cell ◽  
Stem Cell Research ◽  
Scientific Community ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Medical Researchers ◽  
Medical Benefits

 Research on embryonic stem cells has generated great intrigue in the scientific community. Many medical researchers consider stem cell-based therapies to have the potential of treating a host of human ailments and yielding a number of medical benefits. They are motivated by the possibility of treating incurable diseases or facilitating effective treatment methods. Their enthusiasm is shared by many of those who are afflicted with these debilitating diseases.

scholarly journals The action behind the words: embryonic stem cell research marches on

2006 ◽  
Vol 174 (6) ◽  
pp. 743-746 ◽  
Author(s):  
Mitch Leslie
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Embryonic Stem Cell ◽  
Stem Cell Research ◽  
Embryonic Stem ◽  
Embryonic Stem Cell Research ◽  
Medical Resource ◽  
Stem Cell Science

Talk of policy has dominated talk of science for those interested in embryonic stem cell science. But research is continuing, and the advances are making clear why embryonic stem cells are such an important scientific and medical resource.

Genome-wide targets identification of “core” pluripotency transcription factors with integrated features in human embryonic stem cells

2016 ◽  
Vol 12 (4) ◽  
pp. 1324-1332 ◽  
Author(s):  
Leijie Li ◽  
Zhaobin Chen ◽  
Liangcai Zhang ◽  
Guiyou Liu ◽  
Jinlian Hua ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Transcription Factors ◽  
Embryonic Stem Cells ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cells ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Genome Wide ◽  
Novel Model

LMA: A novel model to predict target of pluripotency transcriptional factors in human embryonic stem cell.

scholarly journals Ethics in stem cell research

2012 ◽  
Vol 3 (1) ◽  
pp. 13-18
Author(s):  
Md Fakruddin
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Stem Cell Research ◽  
Human Embryonic Stem Cell ◽  
Ethical Issues ◽  
Embryonic Stem ◽  
Cell Types ◽  
Embryonic Stem Cell Research ◽  
Human Embryos

Stem cells have constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types that could be used for treating some of genetic and degenerative disorders. However, human embryonic stem cell research raises few ethical and political controversies because of its involvement in destruction of human embryos. The ethical issues in human embryonic stem cell research encompasses not only with question of the ethics of destroying human embryos, but also with questions about complicity of researchers in destruction of embryos, moral distinction between creating embryos for research purposes and creating them for reproductive ends and the permissibility of cloning human embryos to harvest stem cells. Bangladesh should formulate its own regulations justifying its stand regarding this matter. DOI: http://dx.doi.org/10.3329/bioethics.v3i1.10867 Bangladesh Journal of Bioethics 2012; 3(1):13-18

scholarly journals Similar Population of CD133+ and DDX4+ VSEL-Like Stem Cells Sorted from Human Embryonic Stem Cell, Ovarian, and Ovarian Cancer Ascites Cell Cultures: The Real Embryonic Stem Cells?

Cells ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 706 ◽  
Author(s):  
Irma Virant-Klun ◽  
Petra Skerl ◽  
Srdjan Novakovic ◽  
Eda Vrtacnik-Bokal ◽  
Spela Smrkolj
Keyword(s):  
Ovarian Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Embryonic Stem Cell ◽  
Cell Cultures ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Recurrent Ovarian Cancer

A population of small stem cells with diameters of up to 5 μm resembling very small embryonic-like stem cells (VSELs) were sorted from human embryonic stem cell (hESC) cultures using magnetic-activated cell sorting (MACS) based on the expression of a stem-cell-related marker prominin-1 (CD133). These VSEL-like stem cells had nuclei that almost filled the whole cell volume and expressed stem-cell-related markers (CD133, SSEA-4) and markers of germinal lineage (DDX4/VASA, PRDM14). They were comparable to similar populations of small stem cells sorted from cell cultures of normal ovaries and were the predominant cells in ascites of recurrent ovarian cancer. The sorted populations of CD133+ VSEL-like stem cells were quiescent in vitro, except for ascites, and were highly activated after exposure to valproic acid and follicle-stimulating hormone (FSH), indicating a new tool to study these cells in vitro. These VSEL-like stem cells spontaneously formed clusters resembling tumour-like structures or grew into larger, oocyte-like cells and were differentiated in vitro into adipogenic, osteogenic and neural lineages after sorting. We propose the population of VSEL-like stem cells from hESC cultures as potential original embryonic stem cells, which are present in the human embryo, persist in adult human ovaries from the embryonic period of life and are involved in cancer manifestation.

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