scholarly journals Under the Skin: Russia’s Budding Healthcare Crisis

2017 ◽  
Vol 12 (1) ◽  
pp. 37-42
Author(s):  
Madeline Kehl
Keyword(s):  
Russian Federation ◽  
Multidrug Resistant ◽  
Russian Government ◽  
Health Crisis ◽  
International Media ◽  
Resistant Tuberculosis ◽  
Mdr Tb ◽  
Healthcare Crisis ◽  
The Media ◽  
The Russian Federation

Behind the ghost of the Iron Curtain lurks a public health crisis. Superseded in the media by East-West tension and military flare-ups, infectious disease has launched its own war on the Russian Federation. Besides the HIV epidemic, which has continued to escalate for decades, the Russian Federation has become a greenhouse for multidrug resistant tuberculosis (MDR TB). This problem is not just a problem of the Russian Federation, but has worldwide significance due to the spread of resistant TB. Furthermore, the issue has not received the attention it deserves from the international media or the Russian government.  MDR-TB in Russia needs to be taken more seriously.

scholarly journals Multidrug-Resistant Tuberculosis during Pregnancy: Two Case Reports and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Minakshi Rohilla ◽  
Bharti Joshi ◽  
Vanita Jain ◽  
Jasvinder Kalra ◽  
G. R. V. Prasad
Keyword(s):  
Case Reports ◽  
Multidrug Resistant ◽  
Reproductive Age ◽  
Second Line ◽  
Review Of The Literature ◽  
Health Crisis ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Antituberculosis Treatment ◽  
Mdr Tb

Multidrug-resistant tuberculosis (MDR-TB) is identified from the time of introduction of antituberculosis treatment and is a known worldwide public health crisis affecting women of reproductive age group. Management issues raised by pregnant women with MDR tuberculosis are challenging due to the limited clinical experience available with the use of second line drugs. We hereby report two cases of MDR-TB during pregnancy: one patient was on second line drugs, while another one was evaluated and diagnosed to have MDR-TB in last trimester. At 6 months of follow-up both mothers and babies are doing well. The approach to such cases along with review of the literature is discussed.

TB and HIV in the Russian Federation: Risk Factors of MDR-TB in HIV-infected Patients (review)

MedAlliance ◽  
2020 ◽  
pp. 6-13
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Russian Federation ◽  
Multidrug Resistant ◽  
People Living With Hiv ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Route Of Transmission ◽  
The Russian Federation ◽  
Living With Hiv

In the article, a review of foreign and Russian literature suggests that both multidrug-resistant tuberculosis spread and the HIV epidemic are factors maintaining the high tuberculosis burden worldwide and in the Russian Federation. The main transmission pathway for HIV-infection in the Russian Federation, as well as in other countries of Eastern Europe and Central Asia, is now attributed to heterosexual contact, which has surpassed the intravenous injection route of transmission. A rise in heterosexual risk of HIV transmission is accelerating epidemic progression amongst the general population, thereby contributing to a generalization of the epidemic process. The authors also provide an analytical review of publications related to risk factors for multidrug-resistant tuberculosis development in HIV-infected patients. It is found that such literature is limited in foreign countries, as well as in the Russian Federation. There is information about the general role of HIV infection in tuberculosis burden, but the influence of socio-demographic, epidemiological and clinical factors for multidrug-resistant tuberculosis development in people living with HIV is not sufficiently studied. Thus, there is a need for further studies designed to analyze the socio-demographic, epidemiological and clinical characteristics of patients with multidrug-resistant tuberculosis and HIV co-infection in comparison with those who are HIV-negative. Knowledge of the main risk factors for multidrug-resistant tuberculosis development in people living with HIV will allow selective and targeted use of resources to achieve effective outcomes in treatment of HIV/TB co-infected patients.

METHODS OF TEACHING JOURNALISM AND THE FORMATION OF A CONVERGENT EDITION IN THE FORMAT OF A PRE-UNIVERSITY EDUCATIONAL INSTITUTION OF THE MINISTRY OF DEFENSE OF THE RUSSIAN FEDERATION

2020 ◽  
Author(s):  
Мария Минаиловна Чевычелова
Keyword(s):  
General Education ◽  
Russian Federation ◽  
Educational Institution ◽  
Media Center ◽  
The Media ◽  
The Russian Federation

В статье рассматриваются методики преподавания журналистики и особенности деятельности медиацентра в общеобразовательных структурах, овладении профессиональными инструментами воспитанниками филиала НВМУ (Владивостокское ПКУ). The article discusses the methods of teaching journalism and features of the media center in general education structures, mastering professional tools by students of the branch of NVMU (Vladivostok PKU).

scholarly journals The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chathika K Weerasuriya ◽  
Rebecca C Harris ◽  
C Finn McQuaid ◽  
Fiammetta Bozzani ◽  
Yunzhou Ruan ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Effective ◽  
Multidrug Resistant ◽  
Second Line ◽  
Second Line Therapy ◽  
China And India ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Line Therapy ◽  
Mdr Tb

Abstract Background Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the epidemiologic impact, cost-effectiveness, and budget impact of hypothetical novel prophylactic prevention of disease TB vaccines on RR/MDR-TB in China and India. Methods We constructed a deterministic, compartmental, age-, drug-resistance- and treatment history-stratified dynamic transmission model of tuberculosis. We introduced novel vaccines from 2027, with post- (PSI) or both pre- and post-infection (P&PI) efficacy, conferring 10 years of protection, with 50% efficacy. We measured vaccine cost-effectiveness over 2027–2050 as USD/DALY averted-against 1-times GDP/capita, and two healthcare opportunity cost-based (HCOC), thresholds. We carried out scenario analyses. Results By 2050, the P&PI vaccine reduced RR/MDR-TB incidence rate by 71% (UI: 69–72) and 72% (UI: 70–74), and the PSI vaccine by 31% (UI: 30–32) and 44% (UI: 42–47) in China and India, respectively. In India, we found both USD 10 P&PI and PSI vaccines cost-effective at the 1-times GDP and upper HCOC thresholds and P&PI vaccines cost-effective at the lower HCOC threshold. In China, both vaccines were cost-effective at the 1-times GDP threshold. P&PI vaccine remained cost-effective at the lower HCOC threshold with 49% probability and PSI vaccines at the upper HCOC threshold with 21% probability. The P&PI vaccine was predicted to avert 0.9 million (UI: 0.8–1.1) and 1.1 million (UI: 0.9–1.4) second-line therapy regimens in China and India between 2027 and 2050, respectively. Conclusions Novel TB vaccination is likely to substantially reduce the future burden of RR/MDR-TB, while averting the need for second-line therapy. Vaccination may be cost-effective depending on vaccine characteristics and setting.

PP581 Catastrophic Costs Of Multidrug-Resistant Tuberculosis: Estimation Based On The Cost Of Treatment In China

2020 ◽  
Vol 36 (S1) ◽  
pp. 43-43
Author(s):  
Lijun Shen ◽  
Shangshang Gu ◽  
Fan Zhang ◽  
Zhao Liu ◽  
Yuehua Liu
Keyword(s):  
Market Price ◽  
Multidrug Resistant ◽  
Policy Support ◽  
World Health ◽  
Chinese Patients ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Drug Affordability ◽  
The Cost

IntroductionChina bears a considerably high burden of multidrug-resistant tuberculosis (MDR-TB). Second-line anti-TB drugs are urgently needed yet domestic MDR-TB drugs are expensive and lack policy support. Patients’ living conditions are closely related to the drug affordability. The national TB prevention programs should play a critical role. The purpose of this study is to measure the cost of treating MDR-TB patients under different treatment schemes and price sources. The results of this study are expected to inform the relevant drug protection policies and provide inputs for further cost-effectiveness analyses.MethodsBased on the treatment plan of China's Multidrug-Resistant Pulmonary Tuberculosis Clinical Path (2012 edition) and the World Health Organization (WHO) Drug-Resistant Tuberculosis Treatment Guide (2018 edition), the treatment costs of MDR-TB were measured under different scenarios. Catastrophic health expenditure was then calculated if the treatment cost exceeds 40 percent of the household's non-subsistence income. National, rural and disposable income per capita in 2018, were used to represent Chinese patients’ affordability.ResultsUnder varied treatment schemes and market price sources in China, the total costs for MDR-TB patients range from 19,401 to 126,703 CNY [2,853 to 18,633 USD] per person. Under current prices, all treatment schemes recommended by the WHO will incur catastrophic costs for Chinese MDR-TB patients. Significant differences were found between rural and urban areas as 52.8 percent of the treatment listed in the 2012 China Guideline would lead to catastrophic cost for rural patients but not urban ones.ConclusionsOur study concludes that the domestic drugs are more expensive than the international purchase price and the treatment of MDR-TB imposes substantial economic burden on patients, especially in the rural areas. The results of the study also indicate that it is urgent for the state to emphasize government responsibility and initiate centralized procurement for price negotiations to reduce the market price of MDR-TB drugs. The urban-rural gap should also be addressed in the design of future policies to ensure the drug affordability for all patients in need.

scholarly journals Outcomes of Community-Based Systematic Screening of Household Contacts of Patients with Multidrug-Resistant Tuberculosis in Myanmar

2019 ◽  
Vol 5 (1) ◽  
pp. 2
Author(s):  
Nang Thu Thu Kyaw ◽  
Aung Sithu ◽  
Srinath Satyanarayana ◽  
Ajay M. V. Kumar ◽  
Saw Thein ◽  
...  
Keyword(s):  
Chest Radiography ◽  
Multidrug Resistant ◽  
Sputum Smear ◽  
Community Based ◽  
Household Contacts ◽  
Resistant Tuberculosis ◽  
Symptom Screening ◽  
Multidrug Resistant Tuberculosis ◽  
Screening Algorithm ◽  
Mdr Tb

Screening of household contacts of patients with multidrug-resistant tuberculosis (MDR-TB) is a crucial active TB case-finding intervention. Before 2016, this intervention had not been implemented in Myanmar, a country with a high MDR-TB burden. In 2016, a community-based screening of household contacts of MDR-TB patients using a systematic TB-screening algorithm (symptom screening and chest radiography followed by sputum smear microscopy and Xpert-MTB/RIF assays) was implemented in 33 townships in Myanmar. We assessed the implementation of this intervention, how well the screening algorithm was followed, and the yield of active TB. Data collected between April 2016 and March 2017 were analyzed using logistic and log-binomial regression. Of 620 household contacts of 210 MDR-TB patients enrolled for screening, 620 (100%) underwent TB symptom screening and 505 (81%) underwent chest radiography. Of 240 (39%) symptomatic household contacts, 71 (30%) were not further screened according to the algorithm. Children aged <15 years were less likely to follow the algorithm. Twenty-four contacts were diagnosed with active TB, including two rifampicin- resistant cases (yield of active TB = 3.9%, 95% CI: 2.3%–6.5%). The highest yield was found among children aged <5 years (10.0%, 95% CI: 3.6%–24.7%). Household contact screening should be strengthened, continued, and scaled up for all MDR-TB patients in Myanmar.

scholarly journals Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236250
Author(s):  
Chador Tenzin ◽  
Natkamol Chansatitporn ◽  
Tashi Dendup ◽  
Tandin Dorji ◽  
Karma Lhazeen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Multidrug Resistant ◽  
Case Control ◽  
Factors Associated ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb ◽  
Control Study

A study of multidrug resistant tuberculosis among symptomatic household contacts of MDR-TB patients

2020 ◽  
Author(s):  
Benhur Joel Shadrach ◽  
Santosh Kumar ◽  
Kunal Deokar ◽  
Gajendra Vikram Singh ◽  
Hariharan ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Household Contacts ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb
Sign in / Sign up

Export Citation Format

Share Document