scholarly journals A Case of Hyperbaric Oxygen as Adjunct to Fascio-tomies in Compartment Syndrome, Ischemia-Re-perfusion Injury, and Delayed Secondary Infection

2013 ◽  
Vol 1 (2) ◽  
pp. 91-93
Author(s):  
Dawnielle C. Endly ◽  
Joan V. Eggert
Keyword(s):  
Reperfusion Injury ◽  
Compartment Syndrome ◽  
Hyperbaric Oxygen ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Secondary Infection ◽  
Tissue Loss ◽  
Ascending Infection ◽  
Initial Injury

Background: Fasciotomies are a therapeutic treatment for compartment syndrome, but they also allow reperfusion to tissues that have been hypoxic. We report a case study of a 52-year-old male with an ischemic leg. Despite prophylactic fasciotomies, ischemia-reperfusion injury resulted in delayed myonecrosis and progressive necrotizing fasciitis. Results: After two hyperbaric oxygen treatments, edema was markedly reduced and all visible wound tissues were well perfused without evidence of ascending infection, allowing the patient more time for further evaluation. The patient did opt for an above the knee amputation in a non-emergent setting and now successfully utilizes a prosthesis for ambulation. Conclusion: Ischemia-reperfusion injury may result in delayed tissue loss in spite of appropriate fascioto­mies. Hyperbaric oxygen may be a useful adjunct therapy even when initiated days after the initial injury.

Hyperbaric oxygen worsens myocardial low flow ischemia-reperfusion injury in isolated rat heart

1997 ◽  
Vol 320 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Sonia Radice ◽  
Giuseppe Rossoni ◽  
Giorgio Oriani ◽  
Michael Michael ◽  
Enzo Chiesara ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Hyperbaric Oxygen ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Low Flow ◽  
Isolated Rat

scholarly journals An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning

2018 ◽  
Vol 8 (5) ◽  
pp. e00959 ◽  
Author(s):  
Ciprian Hentia ◽  
Alex Rizzato ◽  
Enrico Camporesi ◽  
Zhongjin Yang ◽  
Danina M. Muntean ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Hyperbaric Oxygen ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Protective Strategies ◽  
Hyperbaric Oxygen Preconditioning

scholarly journals Effect of hyperbaric oxygen therapy on the intestinal ischemia reperfusion injury

2011 ◽  
Vol 26 (6) ◽  
pp. 463-469 ◽  
Author(s):  
Rosemary Aparecida Furlan Daniel ◽  
Vinícius Kannen Cardoso ◽  
Emanuel Góis Jr ◽  
Rogério Serafim Parra ◽  
Sérgio Britto Garcia ◽  
...  
Keyword(s):  
Cell Viability ◽  
Reperfusion Injury ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Intestinal Ischemia ◽  
Oxygen Therapy ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Exact Nature ◽  
Intestinal Tissue

PURPOSE: Adequate tissue oxygenation is essential for healing. Hyperbaric oxygen therapy (HBOT) has potential clinical applications to treat ischemic pathologies, however the exact nature of any protective effects are unclear at present. We therefore investigated the potential role of HBOT in modulating the ischemia/reperfusion (I/R) injury response in intestinal model of I/R injury. METHODS: Male Wistar rats were subjected to surgery for the induction of intestinal ischemia followed by reperfusion. HBOT was provided before and/or after intestinal ischemia. Cell viability in the intestinal tissue was assessed using the MTT assay and by measuring serum malondealdehyde (MDA). Microvascular density and apoptosis were evaluated by immunohistochemistry. RESULTS: The results indicate that HBOT treatment pre- and post-ischemia reduces lesion size to the intestinal tissue. This treatment increases cell viability and reduces the activation of caspase-3, which is associated with increased number of tissue CD34 cells and enhanced VEGF expression. CONCLUSION: The hyperbaric oxygen therapy can limit tissue damage due to ischemia/reperfusion injury, by inducing reparative signaling pathways.

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