scholarly journals Rheological Properties of Erythrocytes and Lipid Profiles of Blood Plasma

JMED Research ◽  
2015 ◽  
pp. 1-5
Author(s):  
L. N. Katiukhin ◽  
2011 ◽  
Vol 32 (1) ◽  
pp. 165-176 ◽  
Author(s):  
Jin M. Jung ◽  
Yong Yang ◽  
Dong H. Lee ◽  
Greg Fridman ◽  
Alexander Fridman ◽  
...  

2017 ◽  
Vol 9 (5) ◽  
pp. 3895-3901 ◽  
Author(s):  
Diego F. Tirado ◽  
Katherine Paternina-Sierra ◽  
Diofanor Acevedo-Correa ◽  
Kevin José González- Morelo ◽  
Piedad Margarita Montero-Castillo

2020 ◽  
Vol 12 ◽  
Author(s):  
Diksha Sharma ◽  
Neeraj Tripathi

Background: Microcantilever devices are widely used in biomedical because of its high sensitivity, better performance, low fabrication cost, robustness, and improved reliability over other equipment. The dynamic response of the device, in different medium i.e. air, water, gas, depends on the vibrational mode. Vibrational modes decide how effectively the cantilever is going to respond while operating in a particular medium. Method: In this paper, microcantilever having length 60µm, width 6µm, and thickness 1.5µm has been designed for measuring density and viscosity of blood plasma. A finite element analysis (FEA) is adopted to obtain the eigenfrequencies of the microcantilever device for different beam lengths in the ‘vacuum’ medium. The model for fluid-structure interaction has been presented and analyzed. Since the properties of blood and glycerol are analogous to each other, thus different concentrations of glycerol have been taken to deduce the rheological properties of the fluid. Result: The analytical results are found in close agreement with the FEA results. A comparative analysis of transverse and lateral vibrational modes is put forward to understand the behavior of the device. Also, after simulating the model, it is observed that the cantilever can measure viscosities from 0.86-3.02 centipoise. Conclusion: FEM analysis of microcantilevers vibrating in the vacuum has been presented. Resonant frequencies in the vacuum of laterally and transversally vibrating microcantilever are calculated through an eigenfrequency analysis using Comsol multiphysics software thus avoiding simulation time. A high degree of accuracy of the results is obtained. It is proved experimentally the advantages of lateral vibrations over transverse vibrations. Also, the Simulink model is proposed for measuring the rheological properties of blood. The design is capable of measuring the blood plasma viscosities range. Our study shows that FEM analysis is a suitable tool for designing and simulation of bioMEMS.


Author(s):  
Jiwoon Kim ◽  
Ji Sun Nam ◽  
Heejung Kim ◽  
Hye Sun Lee ◽  
Jung Eun Lee

Abstract. Background/Aims: Trials on the effects of cholecalciferol supplementation in type 2 diabetes with chronic kidney disease patients were underexplored. Therefore, the aim of this study was to investigate the effects of two different doses of vitamin D supplementation on serum 25-hydroxyvitamin D [25(OH)D] concentrations and metabolic parameters in vitamin D-deficient Korean diabetes patients with chronic kidney disease. Methods: 92 patients completed this study: the placebo group (A, n = 33), the oral cholecalciferol 1,000 IU/day group (B, n = 34), or the single 200,000 IU injection group (C, n = 25, equivalent to 2,000 IU/day). 52% of the patients had less than 60 mL/min/1.73m2 of glomerular filtration rates. Laboratory test and pulse wave velocity were performed before and after supplementation. Results: After 12 weeks, serum 25(OH)D concentrations of the patients who received vitamin D supplementation were significantly increased (A, -2.4 ± 1.2 ng/mL vs. B, 10.7 ± 1.2 ng/mL vs. C, 14.6 ± 1.7 ng/mL; p < 0.001). In addition, the lipid profiles in the vitamin D injection group (C) showed a significant decrease in triglyceride and a rise in HDL cholesterol. However, the other parameters showed no differences. Conclusions: Our data indicated that two different doses and routes of vitamin D administration significantly and safely increased serum 25(OH)D concentrations in vitamin D-deficient diabetes patients with comorbid chronic kidney disease. In the group that received the higher vitamin D dose, the lipid profiles showed significant improvement, but there were no beneficial effects on other metabolic parameters.


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