scholarly journals Effects of Long-Term Cobalamin Treatment on the Expression of the Epidermal Growth Factor System in Mouse Kidney

2014 ◽  
pp. 1-10
Author(s):  
Elena Mutti ◽  
◽  
Lise Kristensen ◽  
Henrik Birn ◽  
Dorte Lildballe ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mouse Kidney ◽  
Epidermal Growth ◽  
Factor System

scholarly journals Clinicopathological variables of sporadic schwannomas of peripheral nerve in 291 patients and expression of biologically relevant markers

2018 ◽  
Vol 129 (3) ◽  
pp. 805-814 ◽  
Author(s):  
Eric D. Young ◽  
Davis Ingram ◽  
William Metcalf-Doetsch ◽  
Dilshad Khan ◽  
Ghadah Al Sannaa ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Peripheral Nerve ◽  
Tumor Cells ◽  
Tissue Microarray ◽  
Growth Factor Receptor ◽  
Nerve Sheath ◽  
Epidermal Growth

OBJECTIVEWhile sporadic peripheral schwannomas (SPSs) are generally well treated with surgery, their biology is not well understood. Consequently, treatment options are limited. The aim of this study was to provide a comprehensive description of SPS. The authors describe clinicopathological features and treatment outcomes of patients harboring these tumors, and they assess expression of biomarkers using a clinically annotated tissue microarray. Together, these data give new insight into the biology and management of SPS.METHODSPatients presenting with a primary SPS between 1993 and 2011 (n = 291) were selected from an institutional registry to construct a clinical database. All patients underwent follow-up, and short- and long-term outcomes were assessed. Expression of relevant biomarkers was assessed using a new tissue microarray (n = 121).RESULTSSPSs were generally large (mean 5.5 cm) and frequently painful at presentation (55%). Most patients were treated with surgery (80%), the majority of whom experienced complete resolution (52%) or improvement (18%) of their symptoms. Tumors that were completely resected (85%) did not recur. Some patients experienced short-term (16%) and long-term (4%) complications postoperatively. Schwannomas expressed higher levels of platelet-derived growth factor receptor–β (2.1) than malignant peripheral nerve sheath tumors (MPNSTs) (1.5, p = 0.004) and neurofibromas (1.33, p = 0.007). Expression of human epidermal growth factor receptor–2 was greater in SPSs (0.91) than in MPNSTs (0.33, p = 0.002) and neurofibromas (0.33, p = 0.026). Epidermal growth factor receptor was expressed in far fewer SPS cells (10%) than in MPNSTs (58%, p < 0.0001) or neurofibromas (37%, p = 0.007). SPSs more frequently expressed cytoplasmic survivin (66% of tumor cells) than normal nerve (46% of cells), but SPS expressed nuclear survivin in fewer tumor cells than in MPNSTs (24% and 50%, respectively; p = 0.018).CONCLUSIONSComplete resection is curative for SPS. Left untreated, however, these tumors can cause significant morbidity, and not all patients are candidates for resection. SPSs express a pattern of biomarkers consistent with the dysregulation of the tumor suppressor merlin observed in neurofibromatosis Type 2–associated schwannomas, suggesting a shared etiology. This SPS pattern is distinct from that of other tumors of the peripheral nerve sheath.

Expression of the Epidermal Growth Factor System in Eutopic Endometrium from Women with Endometriosis Differs from That in Endometrium from Healthy Women

2009 ◽  
Vol 67 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Kirsten Ejskj&aelig;r ◽  
Boe Sandahl Sorensen ◽  
Steen Seier Poulsen ◽  
Ole Mogensen ◽  
Axel Forman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Eutopic Endometrium ◽  
Healthy Women ◽  
Epidermal Growth ◽  
Factor System

scholarly journals Repair of chronic tympanic membrane perforations with long-term epidermal growth factor

1995 ◽  
Vol 105 (12) ◽  
pp. 1300-1304 ◽  
Author(s):  
Douglas W. Dvorak ◽  
Greg Abbas ◽  
Tatar Ali ◽  
Sherman Stevenson ◽  
D. Bradley Welling
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforations ◽  
Epidermal Growth

Expression of the epidermal growth factor system in human middle ear cholesteatoma

2013 ◽  
Vol 134 (2) ◽  
pp. 124-134 ◽  
Author(s):  
Mette Bendixen Thorup ◽  
Mathias Munk ◽  
Steen Seier Poulsen ◽  
Michael Gaihede ◽  
Ebba Nexo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Middle Ear ◽  
Middle Ear Cholesteatoma ◽  
Epidermal Growth ◽  
Factor System ◽  
Human Middle Ear
Sign in / Sign up

Export Citation Format

Share Document