scholarly journals Comparative Analysis of Biological Properties of Influenza А (Н1N1) pdm09 Virus Strains isolated in the Pandemic of 2009 and the Post-Pandemic Period in the Asian Part of Russia

2013 ◽  
pp. 1-13
Author(s):  
E. A. Prokopeva ◽  
S. G. Sayfutdinova ◽  
A. V. Glushchenko, ◽  
O. G. Kurskaya ◽  
A. V. Zaykovskaya ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Biological Properties ◽  
Pdm09 Virus ◽  
Virus Strains

scholarly journals Temporal Dominance of B.1.1.7 over B.1.354 SARS-CoV-2 Variant: A Hypothesis Based on Areas of Variant Co-Circulation

2021 ◽  
Author(s):  
Evangelia Georgia Kostaki ◽  
Ioulia Tseti ◽  
Sotirios Tsiodras ◽  
George N. Pavlakis ◽  
Petros P. Sfikakis ◽  
...  
Keyword(s):  
South Africa ◽  
Monoclonal Antibodies ◽  
Comparative Analysis ◽  
Biological Properties ◽  
Community Transmission ◽  
Temporal Dominance ◽  
Over Time

Some emergent SARS-CoV-2 variants raise concerns due to their altered biological properties. For both B.1.1.7 and B.1351 variants, named as variants of concern (VOC), increased transmissibility was reported, whereas B.1.351 was more resistant to multiple monoclonal antibodies (mAbs), as well as convalescent and vaccination sera. To test this hypothesis, we examined the proportion of VOC over time across different geographic areas where the two VOC, B.1.1.7 and B.1.351, co-circulate. Our comparative analysis was based on the number of SARS-CoV-2 sequences on GISAID database. We report that B.1.1.7 dominates over B.1.351 in geographic areas where both variants co-circulate and the B.1.1.7 was the first variant introduced in the population. The only areas where B.1.351 was detected at higher proportion were South Africa and Mayotte in Africa, where this strain was associated with increased community transmission before the detection of B.1.1.7. The dominance of B.1.1.7 over B.1.351 could be important since B.1.351 was more resistant to certain mAbs, as well as heterologous convalescent and vaccination sera, thus suggesting that it may be transmitted more effectively in people with pre-existing immunity to other VOC. This scenario would lessen the effectiveness of vaccine and urge the need to update them with new strains.

scholarly journals Comparative analysis of immune responses following experimental infection of pigs with European porcine reproductive and respiratory syndrome virus strains of differing virulence

2013 ◽  
Vol 163 (1-2) ◽  
pp. 1-12 ◽  
Author(s):  
Eefke Weesendorp ◽  
Sophie Morgan ◽  
Norbert Stockhofe-Zurwieden ◽  
Ditta J. Popma-De Graaf ◽  
Simon P. Graham ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immune Responses ◽  
Experimental Infection ◽  
Respiratory Syndrome Virus ◽  
Virus Strains

Comparative analysis of rabbit hemorrhagic disease virus strains originating from outbreaks in the Russian Federation

2016 ◽  
Vol 161 (7) ◽  
pp. 1973-1979 ◽  
Author(s):  
Galina Burmakina ◽  
Nina Malogolovkina ◽  
Andrey Lunitsin ◽  
Ilya Titov ◽  
Sodnom Tsybanov ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Disease Virus ◽  
Russian Federation ◽  
Rabbit Hemorrhagic Disease Virus ◽  
Hemorrhagic Disease ◽  
Rabbit Hemorrhagic Disease ◽  
The Russian Federation ◽  
Virus Strains

scholarly journals The genome of herpesvirus of turkeys: comparative analysis with Marek’s disease viruses

2001 ◽  
Vol 82 (5) ◽  
pp. 1123-1135 ◽  
Author(s):  
Brewster F. Kingham ◽  
Vladimır Zelnık ◽  
Juraj Kopáček ◽  
Vladimır Majerčiak ◽  
Erik Ney ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
T Cell ◽  
Nucleotide Sequence ◽  
Cell Lymphoma ◽  
Biological Properties ◽  
Marek's Disease ◽  
Marek’S Disease ◽  
Potential Significance ◽  
Internal Repeat ◽  
Herpesvirus Of Turkeys

The complete coding sequence of the herpesvirus of turkeys (HVT) unique long (UL) region along with the internal repeat regions has been determined. This allows completion of the HVT nucleotide sequence by linkage to the sequence of the unique short (US) region. The genome is approximately 160 kbp and shows extensive similarity in organization to the genomes of Marek’s disease virus serotypes 1 and 2 (MDV-1, MDV-2) and other alphaherpesviruses. The HVT genome contains 75 ORFs, with three ORFs present in two copies. Sixty-seven ORFs were identified readily as homologues of other alphaherpesvirus genes. Seven of the remaining eight ORFs are homologous to genes in MDV, but are absent from other herpesviruses. These include a gene with similarity to cellular lipases. The final, HVT-unique gene is a virus homologue of the cellular NR-13 gene, the product of which belongs to the Bcl family of proteins that regulate apoptosis. No other herpesvirus sequenced to date contains a homologue of this gene. Of potential significance is the absence of a complete block of genes within the HVT internal repeat that is present in MDV-1. These include the pp38 and meq genes, which have been implicated in MDV-1-induced T-cell lymphoma. By implication, other genes present in this region of MDV-1, but missing in HVT, may play important roles in the different biological properties of the viruses.

scholarly journals Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of Flaviviridae.

2021 ◽  
Author(s):  
Connor G G Bamford ◽  
William Marciel Souza ◽  
Rhys Parry ◽  
Robert J Gifford
Keyword(s):  
Comparative Analysis ◽  
Dna Sequences ◽  
Domain Knowledge ◽  
Global Scale ◽  
Biological Properties ◽  
Animal Evolution ◽  
Novel Approach ◽  
Animal Phyla ◽  
Genomic Studies ◽  
Positive Strand Rna

The flaviviruses (family Flaviviridae) are a group of positive-strand RNA viruses, many of which pose serious risks to human health on a global scale. Here, we calibrate the timeline of flavivirus evolution using flavivirus-derived DNA sequences identified in animal genomes. We demonstrate that the family is at least 100 million years old and show that this timing can be integrated with dates inferred from co-phylogenetic analysis and paleontological records to produce a cohesive overview of flavivirus evolution in which the main subgroups originate early in animal evolution and broadly co-diverge with animal phyla. In addition, we show that the arthropod-borne 'classical' flaviviruses first evolved from tick-specific viruses, and only later adapted to become insect-borne. Our findings demonstrate that the biological properties of flaviviruses have been acquired over many millions of years of evolution, implying that broad-scale comparative analysis can reveal fundamental insights into flavivirus biology. We implement a novel approach to computational genomic studies of viruses that can support these efforts by enabling more efficient utilization of evolution-related domain knowledge in virus research.

scholarly journals Comparative analysis of total salivary lipopolysaccharide chemical and biological properties with periodontal status

2020 ◽  
Vol 110 ◽  
pp. 104633
Author(s):  
Clare Mcilwaine ◽  
Alexander Strachan ◽  
Zoe Harrington ◽  
Matthew Jerreat ◽  
Louise A. Belfield ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Biological Properties ◽  
Periodontal Status

scholarly journals Temporal Dominance of B.1.1.7 over B.1.354 SARS-CoV-2 Variant: A Hypothesis Based on Areas of Variant Co-Circulation

Life ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 375
Author(s):  
Evangelia Georgia Kostaki ◽  
Ioulia Tseti ◽  
Sotirios Tsiodras ◽  
George N. Pavlakis ◽  
Petros P. Sfikakis ◽  
...  
Keyword(s):  
South Africa ◽  
Monoclonal Antibodies ◽  
Comparative Analysis ◽  
Biological Properties ◽  
Community Transmission ◽  
Temporal Dominance ◽  
Over Time

Some emergent SARS-CoV-2 variants raise concerns due to their altered biological properties. For both B.1.1.7 and B.1351 variants, named as variants of concern (VOC), increased transmissibility was reported, whereas B.1.351 was more resistant to multiple monoclonal antibodies (mAbs), as well as convalescent and vaccination sera. To test this hypothesis, we examined the proportion of VOC over time across different geographic areas where the two VOC, B.1.1.7 and B.1.351, co-circulate. Our comparative analysis was based on the number of SARS-CoV-2 sequences on GISAID database. We report that B.1.1.7 dominates over B.1.351 in geographic areas where both variants co-circulate and the B.1.1.7 was the first variant introduced in the population. The only areas where B.1.351 was detected at higher proportion were South Africa and Mayotte in Africa, where this strain was associated with increased community transmission before the detection of B.1.1.7. The dominance of B.1.1.7 over B.1.351 could be important since B.1.351 was more resistant to certain mAbs, as well as heterologous convalescent and vaccination sera, thus suggesting that it may be transmitted more effectively in people with pre-existing immunity to other VOC. This scenario would lessen the effectiveness of vaccine and urge the need to update them with new strains.

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