scholarly journals Stemming the Degeneration: IVD Stem Cells and Stem Cell Regenerative Therapy for Degenerative Disc Disease

2013 ◽  
pp. 1-22 ◽  
Author(s):  
Sivakamasundari V ◽  
Thomas Lufkin
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Degenerative Disc Disease ◽  
Regenerative Therapy ◽  
Disc Disease ◽  
Degenerative Disc

scholarly journals A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ajay Matta ◽  
Muhammad Zia Karim ◽  
Hoda Gerami ◽  
Bettina Benigno ◽  
W. Mark Erwin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Degenerative Disc Disease ◽  
Molecular Therapy ◽  
Disc Disease ◽  
Mesenchymal Stem Cell Transplantation ◽  
Degenerative Disc

AbstractCellular replacement therapy using mesenchymal stem cells (MSCs) and/or the delivery of growth factors are at the forefront of minimally invasive biological treatment options for Degenerative Disc Disease (DDD). In this study, we compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage derived stem cells (rCDSCs), bone marrow stem cells (rBMSCs) and human Umbilical Cord Derived Mesenchymal Stem Cells (hUCMSCs) for the treatment of DDD. We induced DDD using a validated image-guided needle puncture injury in rat-tail IVDs. Ten weeks post-injury, animals were randomized and injected with MSCs, NTG-101 or vehicle. At the end of the study, histological analysis of the IVD-Nucleus Pulposus (NPs) injected with NTG-101 or rCDSCs showed a healthy or mild degenerative phenotype in comparison to vehicle controls. Immunohistochemical analysis revealed strong expression of aggrecan, collagen 2, brachyury and Oct4 in IVD-NPs injected with NTG-101. Our results also demonstrated suppression of inflammation induced p38 and NFκB resulting in inhibition of catabolic genes, but activation of Smad-2/3, Erk-1/2 and Akt-dependent signaling inducing anabolic genes in IVD-NP on treatment with NTG-101. In conclusion, a single injection of NTG-101 into the degenerative disc demonstrated superior benefits compared to stem cell transplantation.

Regeneration Potential of Stem Cell in the Treatment of IVD

2021 ◽  
Vol 9 (8) ◽  
pp. 3022-3036
Author(s):  
Riya Bhanushali
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Intervertebral Disc ◽  
Stem Cell Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Potential Use

Abstract: Degenerative disc disease is a prevalent musculoskeletal disorder in which damaged spinal discs cause pain upon aging, accidental injuries. Spinal discs connect adjacent vertebrae and help in maintaining mobility, flexibility and rotation of spinal cord. Spinal discs also act as shock absorbers. Intervertebral disc (IVD) degeneration is often associated with low back and neck pain, which accounts for disability worldwide. Physical therapy, spinal fusion surgeries reduce severity and symptoms of degenerative disc disease but they are not complete cure for this disease. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative disks by differentiation to chondrocyte-like cells, which produce proteoglycans and type II collagen. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show potential use in cartilage and intervertebral disc (IVD) repair. Regenerative medicine and stem cell therapy hold great promise for treatment of intervertebral disc (IVD) disease. This review discusses about progression of degenerative disc disease, various types of stem cells, potential use of mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs) for the treatment of degenerative disc disease. This review also focuses upon challenges encountered by the application of stem cell therapy for treating degenerative disc disease as well as future perspectives. Keywords: IVD, Stem cell therapy, AF & NP cells, MSCs, Scaffolds, Cell therapy

scholarly journals Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
David Oehme ◽  
Tony Goldschlager ◽  
Peter Ghosh ◽  
Jeffrey V. Rosenfeld ◽  
Graham Jenkin
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Degenerative Disc Disease ◽  
Low Back ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Disc Regeneration

Low back pain and degenerative disc disease are a significant cause of pain and disability worldwide. Advances in regenerative medicine and cell-based therapies, particularly the transplantation of mesenchymal stem cells and intervertebral disc chondrocytes, have led to the publication of numerous studies and clinical trials utilising these biological therapies to treat degenerative spinal conditions, often reporting favourable outcomes. Stem cell mediated disc regeneration may bridge the gap between the two current alternatives for patients with low back pain, often inadequate pain management at one end and invasive surgery at the other. Through cartilage formation and disc regeneration or via modification of pain pathways stem cells are well suited to enhance spinal surgery practice. This paper will systematically review the current status of basic science studies, preclinical and clinical trials utilising cell-based therapies to repair the degenerate intervertebral disc. The mechanism of action of transplanted cells, as well as the limitations of published studies, will be discussed.

scholarly journals Treatment of Degenerative Disc Disease With Allogeneic Mesenchymal Stem Cells: Long-term Follow-up Results

2021 ◽  
Vol 105 (2) ◽  
pp. e25-e27
Author(s):  
David C. Noriega ◽  
Francisco Ardura ◽  
Rubén Hernández-Ramajo ◽  
Miguel Ángel Martín-Ferrero ◽  
Israel Sánchez-Lite ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Long Term Follow Up

122. Cartilage derived stem cells: a novel cellular replacement therapy to treat degenerative disc disease

2019 ◽  
Vol 19 (9) ◽  
pp. S59-S60
Author(s):  
William Mark Erwin ◽  
Ajay Matta ◽  
Muhammad Zia Karim ◽  
Hoda Gerami
Keyword(s):  
Stem Cells ◽  
Replacement Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc

Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key?

2021 ◽  
Vol 21 (1) ◽  
pp. 5-19
Author(s):  
Shanmuganathan Rajasekaran ◽  
Dilip Chand Raja Soundararajan ◽  
Chitraa Tangavel ◽  
Sharon Miracle Nayagam ◽  
Sri Vijayanand K S ◽  
...  
Keyword(s):  
Degenerative Disc Disease ◽  
Molecular Targets ◽  
Regenerative Therapy ◽  
Disc Disease ◽  
Degenerative Disc

scholarly journals Stem cell therapy for degenerative disc disease: A review

2021 ◽  
Vol 15 (3) ◽  
pp. 238-248
Author(s):  
Shreya SK ◽  
Pushpa Agrawal ◽  
Shivandappa
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Degenerative Disc Disease ◽  
Current Status ◽  
Disc Disease ◽  
Pilot Studies ◽  
Surgical Interventions ◽  
Degenerative Disc ◽  
Different Types

Degenerative Disc Disease (DDD) is a prevalent musculoskeletal disorder associated with lower back pain that typically occurs with age but can also be precipitated by other factors. At present, the available treatments such as physical therapy, analgesics, anti-inflammatory drugs, and surgical interventions are aimed at addressing the symptoms of the disease but not the degeneration process. Among the various biological disc repair therapies, cell therapy has gained interest as it offers a disc regenerative potential while being minimally invasive. Stem cells have the unique property of differentiating into chondrocytes (specialized cells found in cartilage) that resemble Nucleus Pulposus (NP) cells of the disc. Therefore, stem cells can be used to replace the lost NP cells in the degenerated disc. This reduces inflammation and helps in the regeneration of the degenerated disc. In vitro studies, several animal-based studies, and a few human pilot studies have demonstrated safety and efficacy in the treatment of DDD with different types of Mesenchymal Stem Cells (MSCs), Induced Pluripotent Stem Cells (IPSCs), and Intervertebral Disc Stem Cells (IVDSCs). This review aims to address the current status, recent advancements, and different types of stem cells in degenerated disc therapy.

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