scholarly journals Uji Antioksidan Ekstrak Etanol Buah Asam Jawa (Tamarindus indica L.) Tua dan Muda dengan Metode DPPH

2021 ◽  
Vol 2 (2) ◽  
pp. 55-57
Author(s):  
Dwi Kartika Risfanty ◽  
Irna Ii Sanuriza
Keyword(s):  
Diabetes Mellitus ◽  
Tamarindus Indica

Salah satu yang menjadi penyebab kematian terbesar di dunia adalah penyakit degenerative, bahkan di Indonesia terjadi peningkatan setiap tahunnya. Beberapa jenis penyakit degeneratif menempati peringkat 10 besar diantaranya: penyakit jantung, asam urat, diabetes mellitus, hipertensi dan lainnya memaksa penderita harus rawat inap ataupun rawat jalan di rumah sakit atau puskesmas, juga mengakibatkan penuaan dini karna adanya penurunan kolagen dan elastase pada kulit akibat terpapar radikal bebas.  Penyakit ini tidak menular namun berlangsung kronis karna terjadinya kemunduran fungsi sel dan organ. Penyebabnya adalah radikal bebas dan juga dipengaruhi oleh gaya hidup. Mencegah efek negatif dari radikal bebas yakni dengan senyawa antioksidan. Buah asam jawa mengandung senyawa antioksidan. Penelitian ini bertujuan untuk menguji aktivitas antioksidan yang ada pada buah asam jawa muda dan tua, setelah itu membandingkan hasil dari keduanya. Metode yang digunakan dalam penelitian ini adalah metode uji DPPH untuk mengetahui seberapa tinggi aktivitas antioksidan (penangkapan radikal bebas) buah asam jawa muda dan tua. Hasil pengujian aktivitas antioksidan buah asam jawa muda dan tua menunjukkan bahwa buah asam jawa tua memiliki aktivitas antioksidan lebih tinggi yakni 85,28 %, sedangkan buah asam jawa muda 78,87 %.  Kata kunci: aktivitas antioksidan, radikal bebas, penyakit degeneratif dan DPPH

scholarly journals PENGARUH DOSIS DAN LAMA PEMBERIAN EKSTRAK DAUN ASAM JAWA (TAMARINDUS INDICA LINN) TERHADAP HOMA-Β PADA TIKUS MODEL DIABETES MELLITUS TIPE 2 The effect of Tamarind Leaf (tamarindus indica linn) Extract on HOMA-β in Rats with Type 2 Diabetes Mellitus Model

2021 ◽  
Vol 16 (3) ◽  
pp. 267
Author(s):  
Devi Novia ◽  
Sugiarto Sugiarto ◽  
Yulia Lanti Dewi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Leaf Extract ◽  
Fasting Blood Glucose ◽  
Diet Group ◽  
Standard Diet ◽  
Tamarindus Indica ◽  
Significant Difference

Nowadays the epidemiological burden of diabetes increases with long life-threatening symptoms and the effects      of antidiabetic drugs. Lack of insulin activity is one of the signs of a drop in diabetes mellitus. The mechanisms in antidiabetic include stimulating β-Langerhans cells which secrete insulin and inhibit enzyme activity. The purpose of this study was to analyze the effect of giving tamarind leaf extract on levels of homa-β in type 2 diabetes mellitus rats. This study used 30 male Wistar rats aged 8-12 weeks with a bodyweight of 150-200 grams and separated into 5 groups. The first group is KN group (DMT2 mice + standard diet), group 2 is KP (DMT2 + Acarbose mice), group 3 is P1 (DMT2 mice + tamarind leaf extract 28 mg / 200gr / day), group 4 is P2 (rat DMT2 + tamarind leaf extract 56 mg/200gr/day), and group 5 is P3 (DMT2 rat + tamarind leaf extract 112 mg / 200gr / day). The measurement method for Homa-β is to use a standardized formula and use the results of blood tests for fasting blood glucose and insulin levels. The results of the inter-variable study using one-way Anova found a significant difference between the levels of homa-β and the administration of tamarind leaves extract in rats with type 2 diabetes mellitus model (p <0.05). There were significant differences in the 5 treatment groups. On the 7th day, there was an increase in homa-β levels in the KP, P1, P2, and P3 groups while in the KN group decreased in homa-β levels. The P3 group was seen to have the highest increase in homa-β levels in the 14th day, but on the 14th day there was no significant difference between the acarbose drug group (99.57 ± 6.41) and the P3 group (15.09 ± 1, 71). The conclusion was the administration of tamarind extract at a dose of 28.56, and 112 mg/kgBW/day significantly increased levels of HOMA-β for 7 and 14 days in rats with type 2 diabetes mellitus.

scholarly journals PENGARUH PEMBERIAN SEDUHAN DAUN ASAM JAWA ( Tamarindus indica L.) TERHADAP PENURUNAN KADAR GULA DARAH PADA MASYARAKAT DESA TANJUNGBUMI KABUPATEN BANGKALAN MADURA

2021 ◽  
Vol 3 (2) ◽  
pp. 71-85
Author(s):  
arista wahyu ningsih ◽  
◽  
Nur Arzy Samsiyeh ◽  
Martina Kurnia Rohmah ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Group ◽  
Blood Sugar ◽  
Statistical Tests ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
Tamarindus Indica ◽  
Significant Difference ◽  
Sugar Levels

Diabetes mellitus is a disease or metabolic disorder that is most often found in society, including one of the diseases or metabolic disorders. Tamarind leaves (Tamarindus indica L) is a plant that can be used as an alternative treatment for Diabetes Mellitus which contains flavonoids, sapoin and tannins, which can lower glucose levels and inhibit glucose absorption in the blood. This study aims to determine the differences in blood sugar levels before and after giving tamarind leaves infusion in the village community of Tanjung Bumi. This type of research is Quasy Experiment Design and purposive sampling technique with a sample of 29 respondents. Based on the results of the paired t-test statistical analysis showed a significant difference (p = 0.000) between the blood sugar levels of the group and placebo. Meanwhile, in the posttest the treatment group after giving tamarind leaves showed the same as the control group, namely p = 0.000, which means that there is also a difference in the decrease in blood sugar levels between the sebelum pemberian perlakuan and posttest. The results of statistical tests with the Independent T-Test showed the results in both groups with a value of p = 0.000, meaning that there was a difference in the decrease in blood sugar levels between the control group and the treatment group. Steeping tamarind leaves has an effect in reducing blood sugar levels in the body

Pemanfaatan Asam Jawa (Tamarindus indica) untuk Menurunkan Kadar Glukosa Darah pada Diabetes Melitus

2019 ◽  
Vol 6 (3) ◽  
pp. 224-229
Author(s):  
Wina Nazula Makrufa
Keyword(s):  
Diabetes Mellitus ◽  
Tamarindus Indica ◽  
Diabetes Melitus

Diabetes mellitus merupakan salah satu penyakit yang sering dialami oleh masyarakat Indonesia. Jumlah penderita diabetes mellitus di Indonesia terus menerus meningkat setiap tahunnya. Pada penderita diabetes mellitus ditemukan peningkatan kadar glukosa darah atau yang disebut sebagai hiperglikemia. Peningkatan kadar glukosa darah disebabkan karena adanya kerusakan dari sel beta pankreas. Akibat dari kerusakan tersebut, insulin yang berguna untuk menyerap glukosa menjadi berkurang. Hal ini terjadi pada penderita diabetes melitus tipe 1. Selain itu, peningkatan kadar glukosa darah juga dapat disebabkan karena sensitivitas sel terhadap insulin berkurang, sehingga kemampuan sel untuk mengambil glukosa dari darah juga berkurang. Terdapat beberapa penelitian yang meneliti tentang pemanfaatan asam jawa atau Tamarindus indica sebagai bahan alami untuk menurunkan kadar glukosa darah. Pada beberapa penelitian menggunakan bagian buah dari asam jawa untuk dibuat menjadi ekstrak dan diberikan kepada hewan percobaan, yaitu mencit yang telah diberikan aloksan sehingga pankreasnya rusak dan mengalami peningkatan kadar glukosa darah. Setelah diberikan ekstrak buah Tamarindus indica, terdapat penurunan kadar glukosa darah yang cukup signifikan. Pada penelitian yang lain yang menggunakan bagian lain dari Tamarindus indica yaitu bagian biji dan daunnya, terdapat penurunan kadar glukosa darah, namun tidak signifikan.

Peer Relationship Problems in Children with Tourette's Disorder or Diabetes Mellitus

1998 ◽  
Vol 39 (5) ◽  
pp. 663-668 ◽  
Author(s):  
Harry N. Bawden ◽  
Aidan Stokes ◽  
Carol S. Camfield ◽  
Peter R. Camfield ◽  
Sonia Salisbury
Keyword(s):  
Diabetes Mellitus ◽  
Peer Relationship ◽  
Tourette’S Disorder ◽  
Relationship Problems ◽  
Tourette's Disorder

Intramuscular Nerve and Neuromuscular Junction Alteration In Extraocular Muscles of Diabetic Mice

1985 ◽  
Vol 43 ◽  
pp. 682-683
Author(s):  
Bruce R. Pachter
Keyword(s):  
Diabetes Mellitus ◽  
Peripheral Nerves ◽  
Sudden Onset ◽  
Extraocular Muscles ◽  
Diabetic Patients ◽  
Oculomotor Palsy ◽  
Third Nerve Palsy ◽  
Patients With Diabetes ◽  
Intramuscular Nerve ◽  
Oculomotor Nerves

Diabetes mellitus is one of the commonest causes of neuropathy. Diabetic neuropathy is a heterogeneous group of neuropathic disorders to which patients with diabetes mellitus are susceptible; more than one kind of neuropathy can frequently occur in the same individual. Abnormalities are also known to occur in nearly every anatomic subdivision of the eye in diabetic patients. Oculomotor palsy appears to be common in diabetes mellitus for their occurrence in isolation to suggest diabetes. Nerves to the external ocular muscles are most commonly affected, particularly the oculomotor or third cranial nerve. The third nerve palsy of diabetes is characteristic, being of sudden onset, accompanied by orbital and retro-orbital pain, often associated with complete involvement of the external ocular muscles innervated by the nerve. While the human and experimental animal literature is replete with studies on the peripheral nerves in diabetes mellitus, there is but a paucity of reported studies dealing with the oculomotor nerves and their associated extraocular muscles (EOMs).

Kaposis sarcoma and diabetes mellitus

1971 ◽  
Vol 104 (4) ◽  
pp. 442-444 ◽  
Author(s):  
R. Tankel
Keyword(s):  
Diabetes Mellitus
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