scholarly journals A comprehensive review on preventive and therapeutic profile of Dadima (Punica granatum L.) as an Aahara Kalpana (dietetic preparations) as depicted in Ayurveda

The Healer ◽  
2021 ◽  
Vol 2 (02) ◽  
pp. 69-80
Author(s):  
VIVEK KUMAR PATEL ◽  
Prof. Rabinarayan Acharya
Keyword(s):  
Punica Granatum ◽  
Clinical Applications ◽  
Human Diet ◽  
Comprehensive Review ◽  
Wide Range ◽  
Punica Granatum L ◽  
Therapeutic Profile

Background: Fruit have been a part of the human diet since the earliest time. Dadima (Punica granatum L.) of family Lytheraceae, is one among the fruits described under Phala Varga (group of fruits), a classification under Ahara Varga (group of dietetic articles) of Charaka Samhita and has been highlighted for its wide range of use as an Ahara (diet), both preventive and curative in different diseased conditions. Aim: To have a comprehensive review on Dadima or its parts as an ingredient in various Ahara Kalpana (dietetic preparations) containing from available classical texts of Ayurveda. Results: Dadima as an ingredient being included in 634 formulations. Among them, 102 are uses as Ahara Kalpana indicated for its internal uses and 1 for external use. There are 39 formulations where Dadima is used as Bhavana Dravya during its preparation. Dadima is also recommended as an anupana for 44 formulations being indicated for various diseases.   Conclusion: Dadima as a fruit, both in preventive and therapeutic, has wide range of clinical applications. It found to be an ingredient in 103 Ahara Kalpana being indicated in 31 different disease conditions. It is also used as an anupana with other drugs for many diseases.  

scholarly journals PHYTOCHEMICAL EVALUATION OF PUNICA GRANATUM L. LEAF EXTRACT

2017 ◽  
Vol 9 (4) ◽  
pp. 14 ◽  
Author(s):  
P. Sreedevi ◽  
K. Vijayalakshmi ◽  
R. Venkateswari
Keyword(s):  
Metabolic Diseases ◽  
Ethanolic Extract ◽  
Punica Granatum ◽  
Leaf Extracts ◽  
Bioactive Substances ◽  
Pharmaceutical Ingredients ◽  
Wide Range ◽  
Leaf Powder ◽  
Potent Drug ◽  
Punica Granatum L

Objective: This study was conducted to assess the phytochemical constituents in Punica granatum L. Leaf extracts (PGLE) using standard methods.Methods: The leaf powder was extracted using solvents namely aqueous, hydroalcohol, ethanol, ethyl acetate and n-hexane. Qualitative and Quantitative phytochemical screenings of PGLE were assessed by standard methods.Results: All the leaf extracts were positive for a wide range of bio-active compounds except n-hexane. The result has showed that the maximum amount of total phenols (394.16 mg/g DW of extract), total tannins (210.5 mg/g DW of extract), flavanoids (147.4 mg/g DW of extract) and total triterpenoids (112 mg/g DW of extract) were noted in ethanolic extract of P. granatum leaf (EPGL). The biological assay revealed that relevant amount of carbohydrate, protein, lipid and alkaloid in EPGL.Conclusion: The findings of this study concluded that the EPGL had potential bioactive substances that may be used as pharmaceutical ingredients for formulation of new or prospective potent drug to cure wide range of metabolic diseases.

scholarly journals Antioxidant Effect of Moroccan Pomegranate (Punica granatum L. Sefri Variety) Extracts Rich in Punicalagin against the Oxidative Stress Process

Foods ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2219
Author(s):  
Lamiae Benchagra ◽  
Hicham Berrougui ◽  
Mohamed Obaidul Islam ◽  
Mhamed Ramchoun ◽  
Samira Boulbaroud ◽  
...  
Keyword(s):  
Biological Activities ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Natural Antioxidants ◽  
Punica Granatum ◽  
Food Preservation ◽  
Anthocyanin Content ◽  
Wide Range ◽  
Phenolic Extract ◽  
Punica Granatum L

Natural antioxidants products are widely distributed in food and medicinal plants. These natural antioxidants, especially polyphenols, exhibit a wide range of biological activities including anti-cancer, anti-inflammatory, and anti-atherosclerosis activities. Pomegranate (Punica granatum L.) is a rich source of polyphenolic components. The purpose of this study was to characterize the phenolic composition and flavonoids and anthocyanin content of different parts (peel and aril) of the Sefri variety of pomegranate. Our results showed that Peel extract was richer in these compounds than that of the Arils, especially in Punicalagin (A and B). DPPH free radical scavenging, reducing power (FRAP), β-carotene bleaching, and hydrogen peroxide scavenging assays revealed a greater dose-dependent activity of pomegranate peel phenolic extract (PPPE) compared to pomegranate aril phenolic extract (PAPE). PPPE was also more potent than PAPE concerning its ability to inhibit conjugated diene formation and to reduce α-tocopherol disappearance induced by CuSO4-mediated LDL peroxidation. Interestingly, both extracts (PPPE and PAPE) significantly inhibited lipid peroxidation and the formation of reactive oxygen species (ROS) in stressed J82 human bladder cancer cells. These results reflect the protective effects that this Moroccan variety of pomegranate can provide against the development of metabolic disorder, cancer, atherosclerosis, and cardiovascular disease. Given these properties, further studies should be undertaken to investigate possible applications of Sefri pomegranate extracts in the fields of food preservation and health supplements.

Punica Granatum L - A nutraceutical functional food

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Priyadharshini K ◽  
Nandan N. ◽  
Sunil Raj ◽  
Kumar NC ◽  
Pooja BL ◽  
...  
Keyword(s):  
Punica Granatum ◽  
Control Treatment ◽  
Oral Lesions ◽  
Viral Pathogens ◽  
Storage Media ◽  
Wide Range ◽  
Plaque Control ◽  
Medicinal Properties ◽  
Dental Applications ◽  
Punica Granatum L

Pomegranate is a widely used plant having medicinal properties. Pomegranates and their extracts may serve as natural alternatives due to their potency against a wide range of bacterial and viral pathogens. The synergistic action of the pomegranate constituents appears to be superior to that of single constituents.Pomegranate provides health benefits, that is, a nutraceutical food. It is used in dentistry as an active ingredient such as mouth rinse for plaque control, treatment of various oral lesions, storage media for avulsed teeth, wound healing. This paper describes the uses of pomegranate, its mechanism and various therapeutic and dental applications.

scholarly journals Identification and quantification of phenolic compounds in pomegranate juices from eight Macedonian cultivars

2019 ◽  
Vol 38 (2) ◽  
pp. 149
Author(s):  
Jasmina Petreska Stanoeva ◽  
Nina Peneva ◽  
Marina Stefova ◽  
Viktor Gjamovski
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Ellagic Acid ◽  
Total Content ◽  
Punica Granatum ◽  
Wide Range ◽  
Health Promoting ◽  
Punica Granatum L ◽  
Unique Chemical

Punica granatum L. is one of the species enjoying growing interest due to its complex and unique chemical composition that encompasses the presence of anthocyanins, ellagic acid and ellagitannins, gallic acid and gallotannins, proanthocyanidins, flavanols and lignans. This combination is deemed responsible for a wide range of health-promoting biological activities.This study was focused on the analysis of flavonoids, anthocyanins and phenolic acids in eight pomegranate varieties (Punica granatum) from Macedonia, in two consecutive years. Fruits from each cultivar were washed and manually peeled, and the juice was filtered. NaF (8.5 mg) was added to 100 ml juice as a stabilizer. The samples were centrifuged for 15 min at 3000 rpm and analyzed using an HPLC/DAD/MSn method that was optimized for determination of their polyphenolic fingerprints.The dominant anthocyanin in all pomegranate varieties was cyanidin-3-glucoside followed by cyanidin and delphinidin 3,5-diglucoside. From the results, it can be concluded that the content of anthocyanins was higher in 2016 compared to 2017. But in contrast, the total content of non-colored polyphenols was around 10 times lower in 2016 compared to the amount found in the same samples in 2017.

scholarly journals Recent Advances of the Medicinal Plant Compound for Combating Pneumonia Disease: A Review

2021 ◽  
Vol 2 (6) ◽  
pp. 1-5
Author(s):  
Megha Patel ◽  
Bhavesh Sharma
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Infectious Diseases ◽  
Curcuma Longa ◽  
Antibacterial Properties ◽  
Punica Granatum ◽  
Primary Health Care System ◽  
Wide Range ◽  
Justicia Adhatoda ◽  
Punica Granatum L

Bacteria, influenza, parasites and fungi are pathogenic microorganisms that cause infectious diseases. Diseases can spread from one individual to another, either directly or indirectly. Infectious diseases are world’s second most common cause of death. Rainforest plants provide about quarter of drugs we need. Scientific research has been carried out on few medicinal plants, but only to small degree. Bacterial susceptibility to currently active antibiotics has necessitated discovery of new antibacterial agents. Several plants are widely used as herbal medicine for treatment of infectious diseases in rural and backward areas of India. This chapter looks over the publications on medicinal plants that are used to cure diseases like malaria, pneumonia. Traditional medicine is preferred primary health care system in many rural areas for variety of reasons, including its affordability and efficacy. The current study focused on existing medicinal plant literature, with ethnobotany, phytochemistry and pharmacology details being highlighted. All of examined plants showed potent action, supporting their conventional uses as well as their ability to cure common diseases. Curcuma longa L., Punica granatum L. and Justicia adhatoda L. were most widely used plant families for pneumonia therapy in research area (each with seven plants); of these, Curcuma longa L., Punica granatum L. and Justicia adhatoda L. had most inhibiting ability against Staphylococcus aureus and Streptococcus pneumoniae. Ascorbic acid, curcumin, vasicine, piperine, quercetin, myricetin and gallic acid have all been derived from these plants and are said to have antibacterial properties. Although Himalayan region has wide range of ethnomedicinal plants used to treat pneumonia, research on in-vivo activity, toxicology, and mechanism of action is minimal. As result, in order to produce novel antibacterial drugs from studied plant species, thorough study of these aspects is needed.

NEW INSIGHTS ON PUNICA GRANATUM L: ANCIENT KNOWLEDGE TO CURRENT RESEARCH

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (10) ◽  
pp. 5-23
Author(s):  
D Swetha ◽  
◽  
G Krishna Mohan
Keyword(s):  
Drug Interactions ◽  
Intestinal Inflammation ◽  
Chemical Constituents ◽  
Punica Granatum ◽  
Clinical Applications ◽  
Historical Background ◽  
Punicic Acid ◽  
Medicinal Value ◽  
Anti Inflammatory ◽  
Punica Granatum L

Pomegranate, Punica granatum L. (Punicacece), is designated as a plant used in folklore and in several systems of medicine like ayurvedic, unani and siddha for treatment of variety of ailments, as it is believed to possess the powers of fertility, abundance and good luck. The last decade had seen virtual explosion of publications on research dealing with the potentials of pomegranate than the preceding years. Findings showed that almost all parts of pomegranate plant comprise several biochemical constituents (polyphenols, anthocyanins, tannins, alkaloids,. etc.) possessing nutritional and medicinal value. Particularly fruit exhibited potential antioxidant, anti-inflammatory, anti-carcinogenic activities and probable mechanisms are also explained. Many of these effects are related to the presence of ellagic acid, ellagitannins (punicalin, punicalagin), punicic acid, others include fatty acids, anthocyanins, flavonoids, phenols, sterols, estrogenic flavonols and minerals. However, the synergistic action of these constituents appeared to be superior than individual constituents. Promising clinical applications include treatment of cancer, obesity, diabetes, infertility, intestinal inflammation, dental conditions and dermatology. Though moderate consumption of pomegranate doesn’t result any adverse effects, some drug interactions are seen (anti-hypertensives, statins and anticoagulants like warfarin), as it inhibits CYP2C9 and CYP3A mediated drug metabolism. Aim of this review is to understand the historical background, nutritional value, chemical constituents, pharmacological activities, safety assessment (acute and sub-chronic toxicity) and drug interactions of fruit with their clinical applications. We have summarized past to current research (past 10 years) done based on antioxidant, anti-inflammatory and anti-cancer activities and tried to establish the mechanisms of action, and also thrown light on ongoing clinical trials.

PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT ACTIVITY AND ACUTE ORAL TOXICITY OF POMEGRANATE (PUNICA GRANATUM L.) FRUIT PEEL EXTRACT

2019 ◽  
pp. 7-14
Author(s):  
Hai Trieu Ly ◽  
Tuan Anh Vo ◽  
Viet Hong Phong Nguyen ◽  
Thi My Sa Pham ◽  
Bich Thao Lam ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Gallic Acid ◽  
Radical Scavenging ◽  
Dry Weight ◽  
Punica Granatum ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Fruit Peel ◽  
Total Polyphenol ◽  
Punica Granatum L

Background: The natural antioxidants have an important role in the prevention of many diseases. The aim of study is to investigate phytochemical components, antioxidant activity and acute oral toxicity of Pomegranate (Punica granatum L.) fruit peel (PFP) extract. Materials and methods: Phytochemicals of PFP were determined by qualitative chemical tests, thin layer chromatography, total polyphenol and flavonoid contents. The PFP extract was evaluated for antioxidant activity by DPPH assay and MDA assay. In vivo acute oral toxicity test was conducted using Karber-Behrens method to determine LD50. Results: Results illustrated that PFP mainly contains flavonoids, alkaloids, tannins, triterpenes, saponins, and coumarins. PFP extract exhibited the total polyphenol and flavonoid contents with 189.97 mg gallic acid equivalent/g dry weight and 9.42 mg quercetin equivalent/g dry weight, respectively. The DPPH free radical scavenging and anti-lipid peroxidation activities of PFP extract were expressed with IC50 value of 4.80 μg/mL and 0.38 μg/ mL, sequentially. Simultaneously, the Dmax (the maximum dose administered to mice that no toxicity was observed) of PFP extract was determined to be 21.28 g/kg, equivalent to 35.64 g dried herb. Conclusion: The PFP extract is relatively safe and revealed high antioxidant activity. Key words: Punica granatum L.; polyphenols; flavonoids; gallic acid; quercetin; antioxidant activity; acute oral toxicity

Anti-Stress Effect of Punica granatum L. Extract against Sleep Deprivation-Induced Impairment

2016 ◽  
Vol 45 (11) ◽  
pp. 1533-1543
Author(s):  
Ju-Ryun Na ◽  
Sunoh Kim ◽  
Ara Jo ◽  
Donghyuck Bae ◽  
Kyo-Nyeo Oh ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Punica Granatum ◽  
Stress Effect ◽  
Punica Granatum L
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