scholarly journals First experience with a new technique: portable gamma camera usage for sentinel lymph node identification in a patient with breast cancer

2018 ◽  
Author(s):  
Zehra Pinar Koc ◽  
◽  
Pinar Pelin Ozcan Kara ◽  
Mustafa Berkesoglu ◽  
Tamer Akca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Camera ◽  
New Technique ◽  
Sentinel Lymph Node Identification ◽  
Portable Gamma Camera ◽  
A New Technique

Sentinella: Portable gamma camera versus conventional scintigram for intraoperative sentinel lymph node detection in breast cancer.

2012 ◽  
Vol 30 (27_suppl) ◽  
pp. 22-22
Author(s):  
Debashis B. Ghosh ◽  
Nikolaus Michalopoulos ◽  
Caspar Wickham ◽  
Timothy Davidson ◽  
Mohammed R. Keshtgar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Camera ◽  
Gamma Probe ◽  
Lymph Node Biopsy ◽  
Breast Cancer Patients ◽  
Medicine Department ◽  
Portable Gamma Camera ◽  
The Uk

22 Background: Sentinel lymph node biopsy (SLNB) is a standard practice for staging the axilla in breast cancer. Access to nuclear medicine department and sentinel node imaging remain an issue in number of hospitals in the UK and rest of the world. Preoperative scintigrams are performed to confirm uptake of radioactivity and localisation of nodes in centres where facilities are available. Sentinella is a portable imaging camera used intraoperatively to produce real time visual localisation of SLNs. Sentinella was tested in a controlled laboratory environment at our centre followed by the first use of this device in breast cancer patients from UK. Methods: Sensitivity and spatial resolution of Sentinella was compared with conventional gamma camera (CGC).Intraoperative Sentinella Scans were performed in 130 patients and their yield compared with Lymphoscintigrams from CGC. Further Sentinella scans were performed after the axilla was deemed clear by silent activity of hand held gamma probe. Results: Sentinella resolution is comparable with the CGC for objects close to the camera. Sentinella detects high radioactivity (500 kBq) faster than CGC (1 vs 2.5min). In cases of low radioactivity (10kBq) Sentinella was equally accurate and faster than CGC, when placed nearer to skin.Intra-operative Sentinella scans detected an average of 2 sentinel nodes compared to 1.4 nodes by CGC scans. Sentinella demonstrated a serial decay in activity with removal of every hot node and its LED guidance helped in detecting residual nodes. Sentinella picked up extra nodes in 5/130 cases after the axilla was found silent using hand held gamma probe. In 2/130 cases extra nodes found using Sentinella had presence of cancer that led to a complete axillary clearance. Conclusions: This data confirms the excellent sensitivity and specificity of the machine in localisation of radioactive nodes. This new imaging technique increases our pick up of SLNs intraoperatively that are missed due to inadequate visualisation and provide a superior detection compared to static scintigram imaging. This portable gamma camera can replace the use of conventional lymphoscintigrams saving camera time and cost.

Sentinel lymph node identification in a primary ductal carcinoma arising in the vulva

2007 ◽  
Vol 17 (2) ◽  
pp. 471-477 ◽  
Author(s):  
J. M. Martinez-Palones ◽  
A. Perez-Benavente ◽  
B. Diaz-Feijoo ◽  
A. Gil-Moreno ◽  
I. Roca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Local Excision ◽  
World Literature ◽  
Ductal Carcinoma ◽  
Rare Event ◽  
Surgical Specimen ◽  
Sentinel Lymph Node Identification ◽  
Inguinofemoral Lymphadenectomy

Primary or metastasic breast-like carcinoma of the vulva is a rare event. Because of the similarity with breast ductal carcinoma, we think that the same principles used for treatment of orthotopic breast cancer can be applied, as well as the use of sentinel lymph node technique, which is widely accepted in the management of early-stage breast cancer. We report a 49-old-year postmenopausal woman who was referred to our institution after small biopsy of a 3.5- × 3-cm right vulvar tumor. Histopathologically, infiltration of the vulvar dermis by a ductal carcinoma of mammary gland type was reported. At operation, the sentinel node technique revealed two sentinel nodes in the right inguinal area. Although these nodes proved negative for malignancy, the patient underwent wide local excision of tumor and complete ipsilateral inguinofemoral lymphadenectomy. The remaining excised nodes were negative. Surgical specimen proved estrogen- and progesterone-positive receptors, the reason for which the patient received tamoxifen adjuvant therapy. This report represents the first case in the world literature of primary breast carcinoma arising in the vulva in which sentinel lymph node identification has been possible. Because of the rarity of this condition, the pathologic similarity of this tumor along with currently accepted guidelines for the management of breast cancer supports the possibility of local excision and sentinel lymph node identification as a possible alternative to inguinofemoral lymphadenectomy

Factors influencing sentinel lymph node identification failure in breast cancer surgery

The Breast ◽  
2008 ◽  
Vol 17 (2) ◽  
pp. 167-171 ◽  
Author(s):  
Kristina Straalman ◽  
Ulrik S. Kristoffersen ◽  
Hanne Galatius ◽  
Charlotte Lanng
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Cancer Surgery ◽  
Breast Cancer Surgery ◽  
Factors Influencing ◽  
Sentinel Lymph Node Identification

Sentinel lymph node identification in breast cancer: a comparison study of deep versus superficial injection of radiopharmaceutical

2009 ◽  
Vol 30 (7) ◽  
pp. 525-532 ◽  
Author(s):  
Flávia Clímaco ◽  
Afrânio Coelho-Oliveira ◽  
Maria Célia Djahjah ◽  
Bianca Gutfilen ◽  
Ana Helena Pereira Correia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Comparison Study ◽  
Sentinel Lymph Node Identification

An Extended Phase II Trial of Iodine-125 Methylene Blue for Sentinel Lymph Node Identification in Women with Breast Cancer

2013 ◽  
Vol 216 (4) ◽  
pp. 599-605 ◽  
Author(s):  
William W. Harkrider ◽  
Anne E. Diebold ◽  
Thomas Maloney ◽  
Gregory Espenan ◽  
Yi-Zarn Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Methylene Blue ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Extended Phase ◽  
Sentinel Lymph Node Identification ◽  
Iodine 125
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