Efforts for Improving the Efficiency of PSA: PSA Density, PSA Velocity, Age-specific PSA, and Free and Complexed PSA

2013 ◽  
Vol 3 (3) ◽  
pp. 55-60
Author(s):  
Omer Kutlu ◽  
Ismail Turker Koksal
Keyword(s):  
Psa Density ◽  
Psa Velocity

1490: Association of Ethnicity, PSA Velocity and PSA Density Among Patients Found to have Cancer on Repeat Prostate Biopsy

2006 ◽  
Vol 175 (4S) ◽  
pp. 481-482
Author(s):  
Brent V. Yanke ◽  
Brett S. Carver ◽  
Dennis D. Venable ◽  
James A. Eastham
Keyword(s):  
Prostate Biopsy ◽  
Psa Density ◽  
Psa Velocity

scholarly journals A Comparative Performance Analysis of Total PSA, Percentage Free PSA, PSA Velocity, and PSA Density versus the Detection of Primary Circulating Prostate Cells in Predicting Initial Prostate Biopsy Findings in Chilean Men

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Nigel P. Murray ◽  
Eduardo Reyes ◽  
Nelson Orellana ◽  
Cynthia Fuentealba ◽  
Ricardo Dueñas
Keyword(s):  
Prostate Biopsy ◽  
Diagnostic Yield ◽  
Screening Tests ◽  
Total Serum ◽  
Low Grade ◽  
Predictive Values ◽  
Psa Density ◽  
Prostate Cells ◽  
Specificity And Sensitivity ◽  
Psa Velocity

Introduction. PSA parameters have been used in an attempt to improve the diagnostic yield of prostate screening tests; the detection of primary malignant circulating prostate cells (CPCs) may improve the diagnostic yield of screening and therefore avoid unnecessary biopsies.Patients and Methods. Prospective study of all men undergoing initial prostate biopsy due to an elevated total serum PSA. Free percent PSA, PSA velocity, and PSA density were determined. Primary CPCs were detected using standard immunocytochemistry. A positive test for CPCs was defined as one cell PSA (+) P504S (+) in an 8 ml blood sample. Positive predictive and negative predictive values, specificity, and sensitivity were calculated for each test as well as the number of biopsies avoided and cancers missed.Results. 303 men participated in the study of whom 113/303 (37.3%) men had prostate cancer. Of the three PSA based parameters, free percent PSA was superior, sensitivity 70.8%, and specificity 67.4%. Primary CPCs detection had a sensitivity of 88.5% and a specificity of 88.4% avoiding 181 (59.7%) biopsies, detecting 93/95 (98%) of clinically significant cancers, and missing 13 (11.5%) low grade, small volume tumors.Conclusions. The use of primary CPCs as a sequential test could decrease the number of initial prostate biopsies missing those cancers which are treated by active observation.

PSA, PSA density, PSA density of transition zone, free/total PSA ratio, and PSA velocity for early detection of prostate cancer in men with serum PSA 2.5 to 4.0 ng/mL

Urology ◽  
1999 ◽  
Vol 54 (3) ◽  
pp. 517-522 ◽  
Author(s):  
Bob Djavan ◽  
Alexandre Zlotta ◽  
Christian Kratzik ◽  
Mesut Remzi ◽  
Christian Seitz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Detection ◽  
Transition Zone ◽  
Psa Density ◽  
Psa Velocity ◽  
Total Psa

scholarly journals Uloga prostaticnog specificnog antigena u ranoj dijagnozi karcinoma prostate

2003 ◽  
Vol 22 (4) ◽  
pp. 283-288 ◽  
Author(s):  
Natasa Lalic ◽  
Miodrag Acimovic ◽  
Nada Majkic-Singh ◽  
Sava Micic
Keyword(s):  
Psa Density ◽  
Psa Velocity

Prostaticni specificni antigen (PSA) spada u najznacajnije tumorske markere koji se koriste u ranom otkrivanju karcinoma prostate, odredjivanju stadijuma bolesti, kao i pracenju ucinka terapije kod muskaraca sa karcinomom prostate. Standardizacija metoda za odredjivanje PSA komplikuje se pojavom PSA u serumu u obliku vise izoformi od kojih su najznacajnije forme slobodnog PSA, PSA vezanog za alfa-1-antihimotripsin, koje imaju antigene determinante za koje se vezuju razlicita antitela, kao i PSA vezan za alfa-2-makroglobulin, koji nema antigene determinante, tako da se ova izoforma PSA ne moze odrediti pomocu imunoloskih postupaka. Postoji veliki broj imunoloskih metoda za odredjivanje PSA, koje se medjusobno razlikuju po antitelima koja se koriste, po obelezivacu, standardima i po vrednostima PSA koje se dobijaju. Da bi se dizajnirao dobar imunoloski test neophodno je standardizovati kalibratore i odabrati odgovarajuca antitela, pri cemu se mora voditi racuna o ostalim karakteristikama testa kao npr. osobini cvrste faze, kinetici reakcije itd. Posto se nalazi u adenomatoznom, normalnom i kancerogenom tkivu prostate, dijagnosticki znacaj PSA je ogranicen usled preklapanja rezultata kod pacijenata sa karcinomom i benignom hiperplazijom prostate (BPH). Ovo je narocito izrazeno za vrednosti PSA koje se nalaze u tzv. "sivoj zoni", i to izmedju 4,0 i 10,0 ng/mL PSA. Da bi se povecala specificnost za dijagnostiku karcirioma prostate primenjuju se derivati PSA kao sto su: gustina PSA (PSA density) dinamika rasta PSA (PSA velocity), PSA vrednosti korigovane godinama starosti, odredjivanje slobodnog (sl PSA) i kompleksiranog molekula PSA (cPSA) i njihovog odnosa sa ukupnim PSA.

387: The Optimal Timing, Cutoff and Method of Calculation of Preoperative PSA Velocity to Predict Relapse after Prostatectomy: A Report from Search

2007 ◽  
Vol 177 (4S) ◽  
pp. 128-129
Author(s):  
Christopher R. King ◽  
Stephen J. Freedland ◽  
Martha K. Terris ◽  
William J. Aronson ◽  
Christopher J. Kane ◽  
...  
Keyword(s):  
Optimal Timing ◽  
Method Of Calculation ◽  
Psa Velocity

1419: Population-Based PSA Velocity

2007 ◽  
Vol 177 (4S) ◽  
pp. 468-468
Author(s):  
David Connolly ◽  
Amanda Black ◽  
Liam J. Murray ◽  
Anna Gavin ◽  
Patrick F. Keane
Keyword(s):  
Population Based ◽  
Psa Velocity

1749: Correlation between Initial total PSA and PSA Velocity in men with and without Biopsy-Proven Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 581-581
Author(s):  
Jasmin Bektic ◽  
Alexandre E. Pelzer ◽  
Georg Schaefer ◽  
Georg Bartsch ◽  
Wolfgang Horninger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Psa Velocity ◽  
Total Psa

865: Comparison of Preoperative PSA Velocity or PSA Doubling Time as a Predictor of Outcome after Radical Prostatectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 279-279
Author(s):  
Stacy Loeb ◽  
Xiaoying Yu ◽  
Kimberly A. Roehl ◽  
Robert B. Nadler ◽  
Theresa Graif ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Doubling Time ◽  
Psa Doubling Time ◽  
Psa Velocity

950: Pre-Operative PSA Doubling Time is More Powerful than PSA or PSA Velocity as a Predictor of Post Radical Prostatectomy Outcomes

2005 ◽  
Vol 173 (4S) ◽  
pp. 257-257 ◽  
Author(s):  
Shomik Sengupta ◽  
Jeffrey M. Slezak ◽  
Eric J. Bergstralh ◽  
Bradley C. Leibovich ◽  
Robert P. Myers ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Doubling Time ◽  
Psa Doubling Time ◽  
Psa Velocity
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