scholarly journals Evaluation of risk factors for thrombophilia in patients with cerebral venous thrombosis

2010 ◽  
Vol 27 (3) ◽  
pp. 162-167 ◽  
Author(s):  
Osman Yokus ◽  
Ozlem Sahin Balcik ◽  
Murat Albayrak ◽  
Funda Ceran ◽  
Simten Dagdas ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis

scholarly journals Cerebral venous thrombosis in a patient with Down syndrome and coronavirus disease 2019: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Henry Robayo-Amortegui ◽  
Natalia Valenzuela-Faccini ◽  
Cesar Quecano-Rosas ◽  
Darlyng Zabala-Muñoz ◽  
Michel Perez-Garzon
Keyword(s):  
Risk Factors ◽  
Down Syndrome ◽  
Case Report ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Epidemiological Data ◽  
Thromboembolic Disease ◽  
Hispanic Woman ◽  
Case Presentation ◽  
The World

Abstract Background The new coronavirus disease 2019 pandemic has spread throughout most of the world. Cerebral venous thrombosis is a rare thromboembolic disease that can present as an extrapulmonary complication in coronavirus disease 2019 infection. Case presentation We report the case of a Hispanic woman with Down syndrome who has coronavirus disease 2019 and presents as a complication extensive cerebral venous thrombosis. Conclusions Cerebral venous thrombosis is a rare thromboembolic disease that can present as an extrapulmonary complication in coronavirus disease 2019 infection. In the absence of clinical and epidemiological data, it is important to carry out further investigation of the risk factors and pathophysiological causes related to the development of cerebrovascular thrombotic events in patients with Down syndrome with coronavirus disease 2019 infection.

scholarly journals Risk factors and diagnosis of cerebral venous thrombosis: Data from a cohort of 45 Romanian patients

2014 ◽  
Vol 60 (5) ◽  
pp. 207-214
Author(s):  
Rodica Bălaşa ◽  
M Daboczi ◽  
Oana Costache ◽  
Smaranda Maier ◽  
Z Bajko ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Brain Imaging ◽  
Cerebral Venous Thrombosis ◽  
Sinus Thrombosis ◽  
Demographic Data ◽  
Brain Mri ◽  
Clinical Aspects ◽  
Initial Symptom ◽  
Clinical Criteria

Abstract Cerebral venous thrombosis (CVT) represents 1% of the total stroke pathology but is a real challenge both regarding the diagnosis and the treatment. Objective: Evaluate different etiological, demographical, clinical, imaging and therapeutic aspects of CVT. Material: Prospective study during 4 years. From the total 3658 patients hospitalized with acute stroke, 45 (1.23%) had CVT. For each patient, were recorded: demographic data, symptom of onset, type of onset, daily habits, medical history, neurological examination, brain imaging (CT and MRI with venography). Statistical analysis: data are presented as mean and SD and Student t test was applied. Results: Mean age was 44.07± 23,12 years; female: male ratio 2.21:1. The most frequent type of onset was acute (77.78%). Headache was found in 80% of cases as initial symptom, followed by neurological focal deficits. As risk factors, thrombophilia was found most often (59.5%), followed by local infections. No risk factors were found in 17.8% of cases. The brain imaging was positive in 29 patients. In 16 cases, the imaging workout was negative and the diagnosis consisted of clinical criteria, risk factors, response to heparin treatment. Conclusions: CVT is a rare pathology that affects mainly young women and that needs a complex diagnostic evaluation. The patient prototype diagnosed with CVT in our region: female of 44 years old, with an intense acute headache, with MRI showing direct signs of transverse sinus thrombosis, with a thrombophilic state and good response to anticoagulants. Brain MRI is the imaging investigation required but clinical aspects play a decisive role.

Risk factors for cerebral venous thrombosis and deep venous thrombosis in patients aged between 15 and 50 years

2009 ◽  
Vol 102 (10) ◽  
pp. 620-622 ◽  
Author(s):  
Maarten Uyttenboogaart ◽  
Patrick C. A. J. Vroomen ◽  
Jacques De Keyser ◽  
Gert-Jan Luijckx ◽  
Karen Koopman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Contraceptive Use ◽  
Multivariable Logistic Regression Analysis ◽  
Age Group ◽  
Vein Thrombosis ◽  
Oral Contraceptive Use ◽  
Age Dependent ◽  
Deep Vein

SummaryCerebral venous thrombosis (CVT) and deep vein thrombosis or pulmonary embolism (DVT/PE) are associated with many risk factors. It is unclear why CVT occurs less often than DVT/PE. Age dependent risk factors may play a role. The aim of our study was to compare risk factors in a uniform age group of CVT and DVT/PE patients aged between 15 and 50 years. Thrombophilic markers and clinical risk factors of 79 CVT patients and 173 DVT/PE patients aged 15–50 years were compared. Multivariable logistic regression analysis was performed to investigate if risk factors were independently associated with CVT or DVT/ PE. Cerebral venous thrombosis patients were younger (median age 30 years vs. 42 years; p<0.001) and more often female (82% vs. 52%; p<0.001). There were no differences in thrombophilic markers. Cerebral venous thrombosis was less often associated with trauma, immobilisation or surgery than DVT/PE (6% vs. 21%; adjusted OR 0.29; 95%CI 0.10–0.82). In women, CVT was more frequently associated with oral contraceptive use, pregnancy or puerperium (82% vs. 53%; adjusted OR 2.34; 95%CI 1.03–5.32).This study demonstrated no differences in thrombophilic markers between CVT patients and DVT/PE patients aged between 15 and 50 years, while the frequency of some transient risk factors was different. Cerebral venous thrombosis was relatively more common in women and hormonal factors may predispose to CVT compared to DVT/PE, while trauma, immobilisation and surgery may be less important in the pathophysiology of CVT.

European Collaborative Paediatric Database on Cerebral Venous Thrombosis: Risk Factors for Recurrent Venous Thromboembolism.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 276-276
Author(s):  
Gili Kenet ◽  
Fenella Kirkham ◽  
Thomas Niederstadt ◽  
Karin Kurnik ◽  
Rosemarie Schobess ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Cox Regression ◽  
Treatment Guidelines ◽  
Cox Regression Analysis ◽  
G20210a Mutation ◽  
Thrombosis Risk ◽  
Factor Ii ◽  
Prothrombotic Risk Factors

Abstract Background: Risk factors for cerebral venous thrombosis (CVT) in children include local and systemic underlying conditions, drug toxicity, and hereditary prothrombotic risk factors. Their relevance to the risk of a second venous thrombosis (VT), compared with other clinical, neuroimaging and treatment variables, is unknown. Methods: 330 of 407 consecutively enrolled CVT-patients aged newborn to <18 years (median 5.3 years; male 55%) were prospectively followed for a median (range) of 33 (12–84) months. In accordance to international treatment guidelines, 259 children (78.5%) received acute antithrombotic therapy (AT) with UFH or LMWH, followed by long-term AT with LMWH or warfarin in 218 cases (66.0%). Findings: Recurrent VT was diagnosed in 19 of 330 children (5.8%) at a median (range) age of 6 (0.5–84) months following CVT, with no difference observed between the study centres (p=0.84). Multivariate Cox regression analysis revealed that the risk of recurrence was significantly higher in those with older age at first CVT onset (p=0.02), those in whom AT was not administered prior to recurrence (p=0.0003), those who did not have complete patency rates on repeat venography at 3–6 months (p=0.01), and those subjects carrying the factor II G20210A mutation (p=0.03). Interpretation: Age at CVT onset, administration of AT, poor patency rates, and the factor II G20210A variant were of relevance to recurrent VT in children with CVT. Until evidence-based data derived from randomized treatment trials are available the message of this follow-up study is to administer any AT prophylaxis on an individual patient basis in paediatric CVT cases in newly identified VT risk situations.

Ten Years of Cerebral Venous Thrombosis (CVT) in Melbourne, Australia: Male Gender and Presence of Myeloproliferative Neoplasm Is Associated with Thrombotic Recurrence in Unprovoked Events

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4468-4468
Author(s):  
Hui Yin Lim ◽  
Cheryl Ng ◽  
Carole L. Smith ◽  
Geoffrey Donnan ◽  
Harshal Nandurkar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young People ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
False Negative ◽  
Myeloproliferative Neoplasm ◽  
Neurological Deficits ◽  
Haemorrhagic Transformation ◽  
Ct Brain ◽  
Grade Iii

Abstract Aim Cerebral venous thrombosis (CVT) accounts for 0.5-1.0% of all strokes and is a common cause of stroke in young people. The presentations are often heterogeneous and can be associated with significant morbidity and mortality. This review aims to evaluate our local experience in CVT compared to other venous thromboembolism (VTE) with a focus on risk factors for thrombotic recurrence. Methods Retrospective evaluation of consecutive CVT presentations from January 2005 to June 2015, at two major tertiary hospitals in Melbourne, Australia. Data collected included demographics, risk factors, management, complications, modified Rankin score (mRS) and mortality. Results 52 patients (31 female, 21 male) with median age 9.5 (18-83) years, including 4 with cancer, presented with 53 episodes of CVT. Females were younger (32 vs 41 years, p=0.06). Typical presenting symptoms were headache (87%), nausea/vomiting (43%), visual disturbances (38%), focal neurological deficits (28%) and seizures (17%). All but one case was symptomatic, with 53% reporting symptoms in the preceding week. 18 (34%) failed to be diagnosed on initial presentation while 35% (13/37) of CT brain yielded false negative for thrombosis; all of which were subsequently diagnosed on magnetic resonance imaging (MRI) or CT angiography/venography. Commonly thrombosed sinuses included transverse/sigmoid (40%), superior sagittal (11%) or both (43%), with no location-dependent outcome differences. Nine (17%) had CVT-related haemorrhagic transformation and was associated with CVT-related death (2/9 vs 0/44; p=0.04). 28 episodes were provoked - twice more common in female (p=0.02) with 45% attributed to oral contraceptive pill(OCP). 44 patients (85%) had thrombophilia screen performed with 21% positivity. Median duration of anticoagulation was 6.5 months (8 remained on long-term); 78% treated with warfarin. Eight (15%) required intensive care support, while 2 patients required decompressive surgery. 12 (23%) were not followed up in our institutions. At last follow-up of the remaining 40, 2 (5%) had worsening mRS of ³ 2 compared to premorbid, 2 had CVT-related deaths and 2 succumbed to malignancy. 30% reported ongoing symptoms such as headaches, residual neurological deficits, seizures and memory impairment. There were three clot recurrences (1 CVT, 2 portal vein thrombosis) - all male with initial unprovoked events and were subsequently diagnosed with myeloproliferative neoplasm (MPN). Of the 3, one was positive for JAK2V617F mutation. Men with unprovoked CVT had a 20% risk of recurrence, significantly higher compared to women with unprovoked events (3/15 vs 0/10; p=0.02). Clot progression, defined as increased clot burden on repeat imaging, occurred in 2 patients - one was associated with MPN while another progressed in the setting of subtherapeutic anticoagulation post partum. There was one episode of Grade III bleeding (following a procedure) in addition to the 2 (4%) clot-related deaths discussed prior. Table 1.compares the characteristics of CVT and other VTE previously audited by us. Conclusions CVT is rare and may be missed on initial presentation (34%)_with a high degree of clinical suspicion required to improve detection rate. Given there was 35% of CT brain had false negative, MRI or CT angiography is the preferred modality of investigation. It is more common in young people, particularly females on OCP. The presence of haemorrhagic transformation was associated with higher mortality. All thrombotic recurrences in this audit occurred in men with unprovoked events, who were subsequently diagnosed with MPN. This suggests the need for further evaluation, particularly for MPN in males with unprovoked events. Table 1. Comparison between CVT and VTE patients CVT VTE RR; p-value No of patients 52 743 No of episodes 53 753 Incidence 5 cases/year 502 cases/year Median age (years) 39 63 RR 0.39, p<0.001 Male genderRecurrence in males 21 (40%)3 (14%) 367 (49%)33 (9%) p=0.24 Provoked events 28 (53%) 467 (62%) p=0.23 Past VTE history 3 (6%) 157 (21%) RR 0.27, p=0.02 Positive family history 6 (12%) 56 (8%) p=0.29 Thrombophilia screen done (%)Any positive screen 44 (85%)11 (21%) 304 (40%)69 (23%) RR 2.10, p<0.001 p=0.76 Median duration of anticoagulation 6.5m Below knee VTE 3mMajor VTE 6m RecurrenceProvoked 3 (5%)0 (0%) 55 (7%)27 (6%) p=0.79p=0.39 Grade III/IV bleeding 3 (6%) 42 (6%) p=0.98 Non-cancer mortality 2 (4%) 109 (15%) RR 0.28, p=0.07 Disclosures No relevant conflicts of interest to declare.

scholarly journals Clinical presentations, radiological characteristics, and biological risk factors of cerebral venous thrombosis at a University Hospital in Saudi Arabia

2021 ◽  
Vol 42 (2) ◽  
pp. 213-218
Author(s):  
Abdullah S. Alamri ◽  
Mohammed F. Almuaigel ◽  
Zafar Azra ◽  
Foziah J. Alshamrani ◽  
Noor M. AlMohish ◽  
...  
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
University Hospital ◽  
Biological Risk ◽  
Clinical Presentations

scholarly journals Incidence and Mortality of Cerebral Venous Thrombosis in a Norwegian Population

Stroke ◽  
2020 ◽  
Vol 51 (10) ◽  
pp. 3023-3029
Author(s):  
Espen Saxhaug Kristoffersen ◽  
Charlotte Elena Harper ◽  
Kjersti Grøtta Vetvik ◽  
Svetozar Zarnovicky ◽  
Jakob Møller Hansen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
International Classification Of Diseases ◽  
Population Based ◽  
University Hospital ◽  
Motor Deficits ◽  
Cross Sectional ◽  
Norwegian Population ◽  
Incidence And Mortality

Background and Purpose: There are conflicting figures of the incidence of cerebral venous thrombosis (CVT). The incidence was previously estimated to around 0.5/100 000/y, but more recent studies have suggested 1 to 1.5/100 000/y. The purpose of this study was to explore the incidence and mortality of CVT in a Norwegian population. Methods: A retrospective cross-sectional hospital population-based study conducted at Akershus University Hospital serving roughly 10% of the total Norwegian population. Patients were identified through chart reviews based on the relevant International Classification of Diseases ( Tenth Revision ) codes for new CVT cases in a 7-year period between January 1, 2011, and December 31, 2017. Only inhabitants living in the hospital’s catchment area were included. Results: Sixty-two patients aged 0 to 80 years were identified and included. The median age was 46 years and 53% were females. The overall incidence of CVT was 1.75 (95% CI, 1.36–2.23) per 100 000/y with no significant sex differences. The incidence for children and adolescents (<18 years, n=9) was lower than for adults (≥18 years, n=53); 1.08 (0.52–1.97) versus 1.96 (1.49–2.55) per 100 000/y per year, with the highest incidence for those >50 years with 2.10 (1.38–3.07)/100 000/y. Headache was the most prevalent symptom, reported in 83%, followed by nausea, motor deficits, and seizures observed in 45%, 32%, and 32% of the patients. Transverse sinuses and the jugular vein were the most frequent sites of thrombosis. In most patients (61%), thrombosis occurred in multiple sinuses/veins. Risk factors were found in 73% of the patients, and most of the patients had a combination of 2 or more risk factors. The 30-day and 1-year mortality rates were 3% and 6%. Conclusions: The incidence of CVT in this population was higher than previously reported. The mortality rate was similar to previous studies.

Non-genetic and genetic risk factors for adult cerebral venous thrombosis

2018 ◽  
Vol 169 ◽  
pp. 15-22 ◽  
Author(s):  
Mackenzie Green ◽  
Toby Styles ◽  
Timothy Russell ◽  
Charif Sada ◽  
Ebrima Jallow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thrombosis ◽  
Genetic Risk ◽  
Cerebral Venous Thrombosis ◽  
Genetic Risk Factors
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