Hemolytic crisis due to parvovirus B19 in hereditary spherocytosis in two siblings

2015 ◽  
Author(s):  
Meltem Erol ◽  
Ozlem Bostan Gayret ◽  
Ozgul Yigit ◽  
Mahir Tiras ◽  
Sultan Bent
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Hemolytic Crisis

Hemolytic Crisis due to Parvovirus B19 in Hereditary Spherocytosis in Two Siblings

2016 ◽  
Vol 6 (3) ◽  
pp. 194-195
Author(s):  
Meltem Erol ◽  
Ozlem Bostan Gayret ◽  
Ozgul Yigit ◽  
Mahir Tiras ◽  
Sultan Bent
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Hemolytic Crisis

Transient pancytopenia induced by parvovirus B19 in a child with hereditary spherocytosis

2000 ◽  
Vol 76 (4) ◽  
pp. 323-619 ◽  
Author(s):  
Elvis T. Valera ◽  
Rosana Cipolotti ◽  
José E. Bernardes ◽  
Rodolfo C. Pacagnella ◽  
Danielle M. Lima ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19

Management of Hereditary Spherocytosis in a Public Health Care Provider in a Developing Country.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3752-3752
Author(s):  
Leonardo Feldman ◽  
Guillermo Drelichman ◽  
Nora Basack ◽  
Ernesto Rodriguez ◽  
Daniel Freigeiro ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Providers ◽  
Hereditary Spherocytosis ◽  
Public Health Care ◽  
Health Priorities ◽  
European Ancestry ◽  
Care Providers ◽  
Immune Hemolytic Anemia ◽  
Hemolytic Crisis ◽  
Total Splenectomy

Abstract Hereditary Spherocytosis (HS) is the most common cause of non-immune hemolytic anemia in Argentine people of European ancestry, it is characterized by chronic hemolysis, which is reduced or abrogated by splenectomy.. Because of the risk of postsplenectomy sepsis, especially among children under 5 years old, partial splenectomy has been advocated as an alternative. This procedure seems to ensure prolonged reduction but not complete elimination of hemolysis and it is possible some regrowth of the splenic remnant and a secondary total splenectomy must be performed in some patients (pts). This problem is worse especially when pts. live in rural areas and a close observation is necessary. We analyzed retrospectively the evolution of 83 pediatric pts with HS with low resources, other health priorities and in some cases an underling nutritional deficit. Diagnostics was made in a public hospital between October 1971 and December 2002 and the last control was in December 2004. The pts. Median age at diagnostic was 4.7 years (14 days to 14 years). Severe forms were observed in 18%, mild in 20% and moderate in 62%. Twenty four pts were phenotypically sporadic. Biochemical analysis (SDS-PAGE) were performed in 30 pts and/or family members, combined spectrin- ankirin deficiency were observed in most of them. Sixty-nine hemolytic crisis was observed in 30 pts (37.5%). and 17.5% developed an aplastic crisis. Fifty-two pts. (65%) received 249 Red Blood Cell Transfusions (Trs), 36% between 1 and 2, 22.5% 3 to10, and 6% between 10 to 34 Trs. Gallstones were observed in 4 PTs (5%). Total splenectomy was performed in 46 of 83 pts (55%), median age: 7 years (4–15) 42 pts had conventional and 4 have undergone laparoscopyc procedure. Ninety six per cent of pts were splenectomized after age of 5. The median time from diagnostic to splenectomy was 1 year (0.2–8.9). All pts were immunized against Pneumococcus, Haemophilus, and Meningococus and received prophylactic antibiotics. With a median follow up of 18.5 years (3–30 y) after splenectomy all pts showed a significant clinical improvement and no further transfusion requirement. In all cases the hemoglobin increased (median pre and post splenectomy 8.6/13gr/dl) and reticulocyte counts decreased (8 / 1.4%). We do not observe procedure relate mortality, sepsis, thrombosis, and aplastic or hemolytic crisis post-splenectomy. On the basis of our experience we favor the total splenectomy performed by a training team in countries with low resources and in pts with deficient hygienic and housing conditions that inhabit in places with long distances from centers to ensure wider access to training health care providers.

scholarly journals HEMOLYTIC CRISIS DUE TO SALMONELLA ENTEROCOLITIS IN A PATIENT WITH HEREDITARY SPHEROCYTOSIS

1994 ◽  
Vol 44 (4) ◽  
pp. 409-411
Author(s):  
KOUSEI TAMURA ◽  
HITOSHI TAKE ◽  
HITOSHI KURABAYASHI ◽  
ETSUO KAWADA ◽  
KAZUO KUBOTA ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Hemolytic Crisis

scholarly journals Acute parvovirus B19 infection in identical twins unmasking previously unidentified hereditary spherocytosis

2014 ◽  
Vol 2014 (jul29 1) ◽  
pp. bcr2013202957-bcr2013202957 ◽  
Author(s):  
D. G. Forde ◽  
A. Cope ◽  
B. Stone
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Identical Twins ◽  
Parvovirus B19 Infection

scholarly journals An Adult with Aplastic Crisis induced by Human Parvovirus B19 as an Initial Presentation of Hereditary Spherocytosis

2005 ◽  
Vol 20 (1) ◽  
pp. 96 ◽  
Author(s):  
Sook Eui Oh ◽  
Jung Han Kim ◽  
Chi Hun Choi ◽  
Kwang Hyuk Park ◽  
Joo Young Jung ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Initial Presentation ◽  
Human Parvovirus B19 ◽  
Aplastic Crisis

scholarly journals Clinical Case of Aplastic Crisis Associated with Extramedullary Hematopoiesis in an Adult With Hereditary Spherocytosis and Parvovirus B19 Infection

2015 ◽  
Vol 34 (1-2) ◽  
pp. 39-44
Author(s):  
Andreea Jercan ◽  
Rusu Munteanu Gina ◽  
Camelia Dobrea ◽  
Daniel Coriu ◽  
Aurelia Tatic
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Extramedullary Hematopoiesis ◽  
Blood Film ◽  
Red Cell Membrane ◽  
Infectious Episode ◽  
Indirect Bilirubin ◽  
Aplastic Crisis ◽  
Chronic Hemolysis ◽  
Parvovirus B19 Infection

Abstract Hereditary spherocytosis is an inherited hemolytic anemia due to red cell membrane defects, characterised by chronic hemolysis with different severity degrees, splenomegaly and microspherocytosis on the peripheral blood film. Among the possible complications in these patients are aplastic crisis and extramedullary hematopoiesis. In this article we present the case of a 42 years old man with hereditary spherocytosis diagnosed during childhood (average haemoglobin (Hb) value of 11-12 g/dl), which presented with worsening anemia, fever, chills, bone and muscle pain. The evolution was with accentuation of anemia (Hb 4.2 g/dl), decease of reticulocyte number (Ret 0,8%) and bilirubin (indirect bilirubin 2.7 g/dl). ParvovirusB19 DNA was 100.000.000 copies/ml. A computer tomography (CT)scan was performed and showed extramedullary hematopoiesis areas situated paravertebraly in the inferior thorax and hepatosplenomegaly. The infectious episode was self-limited and improved with substitution treatment.

scholarly journals Transient aplastic crisis triggered by parvovirus B19 in a family with hereditary spherocytosis

IDCases ◽  
2020 ◽  
Vol 21 ◽  
pp. e00802
Author(s):  
Nicolas Cilla ◽  
Léa Domitien ◽  
Neila Arrada ◽  
Delphine Chiffre ◽  
Perrine Mahe ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Parvovirus B19 ◽  
Aplastic Crisis ◽  
Transient Aplastic Crisis
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