Investigation of Genetic Polymorphisms in Infective Endocarditis and Artificial Valve Thrombosis

2017 ◽  
Vol 39 (2) ◽  
pp. 63-66
Author(s):  
Aydin Tuncay ◽  
Elif Funda Sener ◽  
Omer Naci Emirogullari
Keyword(s):  
Infective Endocarditis ◽  
Genetic Polymorphisms ◽  
Artificial Valve ◽  
Valve Thrombosis

scholarly journals Hypercoagulation detected by routine and global laboratory hemostasis assays in patients with infective endocarditis

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261429
Author(s):  
Ekaterina M. Koltsova ◽  
Maria A. Sorokina ◽  
Alexandra S. Pisaryuk ◽  
Nikita M. Povalyaev ◽  
Anastasia A. Ignatova ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Genetic Polymorphisms ◽  
Activated Partial Thromboplastin Time ◽  
Coagulation System ◽  
Fibrinogen Concentration ◽  
Consumption Coagulopathy ◽  
Coagulation Assays ◽  
Wide Range ◽  
D Dimer ◽  
Vegetation Formation

Background Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess the coagulation and platelet state in IE implementing a wide range of standard and global laboratory assays. We also aim to determine whether prothrombotic genetic polymorphisms play any role in embolization and mortality in IE patients. Methods 37 patients with IE were enrolled into the study. Coagulation was assessed using standard coagulation assays (activated partial thromboplastin time (APTT), prothrombin, fibrinogen, D-dimer concentrations) and integral assays (thromboelastography (TEG) and thrombodynamics (TD)). Platelet functional activity was estimated by flow cytometry. Single nuclear polymorphisms of coagulation system genes were studied. Results Fibrinogen concentration and fibrinogen-dependent parameters of TEG and TD were increased in patients indicating systemic inflammation. In majority of patients clot growth rate in thrombodynamics was significantly shifted towards hypercoagulation in consistency with D-dimers elevation. However, in some patients prothrombin, thromboelastography and thrombodynamics were shifted towards hypocoagulation. Resting platelets were characterized by glycoprotein IIb-IIIa activation and degranulation. In patients with fatal IE, we observed a significant decrease in fibrinogen and thrombodynamics. In patients with embolism, we observed a significant decrease in the TEG R parameter. No association of embolism or mortality with genetic polymorphisms was found in our cohort. Conclusions Our findings suggest that coagulation in patients with infective endocarditis is characterized by general hypercoagulability and platelet pre-activation. Some patients, however, have hypocoagulant coagulation profile, which presumably can indicate progressing of hypercoagulation into consumption coagulopathy.

scholarly journals 888 Fibrinolytic therapy for right-sided artificial valve thrombosis — our long-term follow-up experience

2003 ◽  
Vol 4 ◽  
pp. S113
Author(s):  
B OBRENOVICKIRCANSKI ◽  
D BOSKOVIC ◽  
B VUJISICTESIC ◽  
I ELEZOVIC ◽  
D BOSKOVIC ◽  
...  
Keyword(s):  
Fibrinolytic Therapy ◽  
Artificial Valve ◽  
Valve Thrombosis ◽  
Long Term Follow Up

scholarly journals Prosthetic valve thrombosis – association of genetic polymorphisms of VKORC1, CYP2C9 and CYP4F2 genes

Medicine ◽  
2019 ◽  
Vol 98 (6) ◽  
pp. e14365 ◽  
Author(s):  
Kalpana SR ◽  
Bharath G ◽  
Simran Jain ◽  
Nagaraja Moorthy ◽  
Satvic C. Manjunath ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Prosthetic Valve ◽  
Prosthetic Valve Thrombosis ◽  
Valve Thrombosis

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk

432: The Genetic Polymorphisms of HPC/ELAC2 and HER-2 Gene Associate with Japanese Sporadic Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 114-114
Author(s):  
Akira Yokomizo ◽  
Hirofumi Koga ◽  
Koji Okumura ◽  
Tatsuo Konomoto ◽  
Taiji Tsukamoto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Genetic Polymorphisms ◽  
Her 2
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