scholarly journals Investigating Maternal Serum Thyroid Hormone, Beta-Human Chorionic Gonadotropin (Beta-HCG) and Free Beta-HCG Levels in Hyperemesis Gravidarum

2015 ◽  
Vol 37 (4) ◽  
pp. 128-132
Author(s):  
Ugur Atmaca ◽  
Mehmet Aral Atalay ◽  
Necati Ozcimen ◽  
Bilhan Sidal ◽  
Ugur Ates
Keyword(s):  
Thyroid Hormone ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Hyperemesis Gravidarum ◽  
Maternal Serum ◽  
Beta Hcg ◽  
Beta Human Chorionic Gonadotropin ◽  
Serum Thyroid Hormone ◽  
Human Chorionic Gonadotropin Beta

scholarly journals Levels of Maternal Serum Alpha-fetoprotein and Beta Human Chorionic Gonadotropin in HIV Seropositive Pregnant Women Attending Antenatal Care at Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria

2021 ◽  
pp. 32-38
Author(s):  
C. H. Udeogu ◽  
M. C. Ugwu ◽  
J. Okwara ◽  
A. C. Ohale ◽  
O. C. Ike ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Test Group ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Beta Human Chorionic Gonadotropin ◽  
Serum Alpha Fetoprotein ◽  
Β Hcg ◽  
Hiv Seropositive

HIV infection remains a worrisome pandemic especially in developing countries like Nigeria, with an increasing number of infected women becoming pregnant, with added risk of pregnancy complications such as intrauterine fetal death, neural tube defects, and vertical transmissions. Hence this study assessed the levels of maternal serum alpha-fetoprotein (MSAFP) and beta human chorionic gonadotropin (β-hCG) in HIV seropositive pregnant women, and their implication for maternal and fetal health. A total of 86 patients were recruited for the study from the Antenatal Clinic of Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi.  Forty three were HIV seropositive (Test group), and forty three were HIV seronegative (Control group). Maternal serum alpha-fetoprotein and beta human chorionic gonadotropin levels were assayed by Enzyme Linked Immunosorbent Assay. The results showed that MSAFP levels (3.14±2.80 ng/ml) were significantly lower (P < .05) in HIV infected pregnant women when compared to HIV uninfected pregnant women (4.75±3.68 ng/ml). There was no significant difference in the levels of β-hCG (217.88±63.85mIU/mL) in the test group (P = 0.629) as compared to controls (223.75±47.71 mIU/mL). In the test group, increased CD4 counts were significantly   associated   with   increased MSAFP and β-hCG levels in a positive fashion (P < .05). Increase in Gestational age was also significantly associated with increased β-hCG levels (P < .05). The measurements of MSAFP and β-hCG levels may be used alongside CD4 count in the assessment of maternal and fetal wellbeing. Human Immunodeficiency Virus by reducing the levels of MSAFP in HIV infected pregnant women increases the likelihood of pregnancy complications such as intrauterine fetal death.

scholarly journals Accuracy of Combined Measure of Serum Uric Acid and Beta Human Chorionic Gonadotropin (β hCG) Versus Serum Beta Human Chorionic Gonadotropin Alone as Prognostic Indicators of Pregnancy Outcome of Preeclampsia

2020 ◽  
pp. 1-9
Author(s):  
E. O. S. Aigere ◽  
D. O. Allagoa ◽  
E. L. Kotingo ◽  
L. Obagah ◽  
B. E. Kasia ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pregnancy Outcome ◽  
Serum Uric Acid ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Prognostic Indicators ◽  
Beta Hcg ◽  
Beta Human Chorionic Gonadotropin ◽  
The Mean ◽  
Β Hcg

Background: Measurement of variety of biological, biochemical and biophysical markers in pregnancy implicated in the pathophysiology of preeclampsia have been proposed to predict its development. Aim: To evaluate the accuracy of combined measure of maternal serum uric acid level and quantitative serum beta hCG versus serum beta hCG alone as prognostic indicators of pregnancy outcome among preeclamptic patients at the Federal Medical Centre, Yenagoa. Methods: This is a hospital based prospective case control study by systematic sampling selection. The two groups comprised of 100 consecutive patients each, one with pre-eclampsia (study group) and the other without pre-eclampsia (control) admitted for management into the antenatal ward and labour ward over the seven-month period of the study. The values of their serum uric acid and beta hCG levels were evaluated on admission and followed up. Data entry and statistical analysis was done using statistical package for social science (windows version 22.0. SPSS Inc; Chicago, USA). Level of significance was set at P < 0.05. Results: The mean quantitative serum β hCG level amongst the subjects (26776.6 ± 19590.5) was statistically significantly higher (p < 0.001) than the mean quantitative serum β hCG level amongst the control (7973.6 ± 4193.7). The prognostic accuracy in predicting pregnancy outcomes were: HELLP syndrome (0.33, 0.44), Eclampsia (0.50, 0.39), Acute Renal Failure (0.44, 0.33), IUGR (0.43, 0.39), IUFD (0.38, 0.27) and Birth Asphyxia (0.49, 0.38) respectively for combined measure of serum uric acid and serum β hCG, and serum β hCG alone. Conclusion: Serum β hCG levels remains a useful prognostic indicator for feto-maternal outcome in preeclamptic women. However, combined measure of serum uric acid and serum β hCG level in prognosticating pregnancy outcome in preeclamptic women was shown to have a better accuracy than serum β hCG.  

Sign in / Sign up

Export Citation Format

Share Document