scholarly journals Effects of Propofol and Midazolam on the Inflammation of Lungs after Intravenous Endotoxin Administration in Rats

2015 ◽  
Vol 47 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Mine Gursac Celik ◽  
Ayten Saracoglu ◽  
Tolga Saracoglu ◽  
Husnu Kursad ◽  
Aysenur Dostbil ◽  
...  
Keyword(s):  
Endotoxin Administration

The effect of endotoxin administration on the pharmacokinetics of chlorzoxazone in humans

1999 ◽  
Vol 66 (6) ◽  
pp. 554-562 ◽  
Author(s):  
S POLOYAC ◽  
R TOSHEVA ◽  
B GARDNER ◽  
S SHEDLOFSKY ◽  
R BLOUIN
Keyword(s):  
Endotoxin Administration

Rapid in vivo induction of leukocyte tissue factor mRNA and protein synthesis following low dose endotoxin administration to rabbits

2001 ◽  
Vol 2 (3) ◽  
pp. 188-195 ◽  
Author(s):  
Tara C Brutzki ◽  
Myron J Kulczycky ◽  
Leslie Bardossy ◽  
Bryan J Clarke ◽  
Morris A Blajchman
Keyword(s):  
Protein Synthesis ◽  
Tissue Factor ◽  
Low Dose ◽  
Endotoxin Administration ◽  
In Vivo Induction

scholarly journals Time Course of Inducible Nitric Oxide Synthase Activity Following Endotoxin Administration in Dogs

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 208-211 ◽  
Author(s):  
Jean-Charles Preiser ◽  
Haibo Zhang ◽  
Bernard Vray ◽  
Andreas Hrabak ◽  
Jean-Louis Vincent
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Time Course ◽  
Endotoxin Administration ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

Endotoxin administration alters the force vs. pCa relationship of skeletal muscle fibers

2000 ◽  
Vol 278 (4) ◽  
pp. R891-R896 ◽  
Author(s):  
G. Supinski ◽  
D. Nethery ◽  
T. M. Nosek ◽  
L. A. Callahan ◽  
D. Stofan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Force ◽  
Fiber Type ◽  
Contractile Proteins ◽  
Hill Coefficient ◽  
Control Group ◽  
Fiber Types ◽  
Endotoxin Administration ◽  
Generating Capacity ◽  
The Hill

Recent work indicates that endotoxemia elicits severe reductions in skeletal muscle force-generating capacity. The subcellular alterations responsible for these decrements have not, however, been fully characterized. One possibility is that the contractile proteins per se are altered in endotoxemia and another is that the mechanism by which these proteins are activated is affected. The purpose of the present study was to assess the effects of endotoxin administration on the contractile proteins by examining the maximum calcium-activated force (Fmax) and calcium sensitivity of single Triton-skinned fibers of diaphragm, soleus, and extensor digitorum longus (EDL) muscles taken from control and endotoxin-treated (8 mg/kg) rats. Fibers were mounted on a force transducer and sequentially activated by serial immersion in solutions of increasing Ca2+ concentration (i.e., pCa 6.0 to pCa 5.0); force vs. pCa data were fit to the Hill equation. All fibers were typed at the conclusion of studies using gel electrophoresis. Fmax, the calcium concentration required for half-maximal activation (Ca50), and the Hill coefficient were compared as a function of muscle and fiber type for the control and endotoxin-treated animals. Control group Fmax was similar for diaphragm, soleus, and EDL fibers, i.e., 112.34 ± 2.64, 111.55 ± 3.66, and 104.05 ± 4.33 kPa, respectively. Endotoxin administration reduced the average Fmax for fibers from all three muscles to 80.25 ± 2.30, 72.47 ± 2.97, and 78.32 ± 2.43 kPa, respectively ( P < 0.001 for comparison of each to control). All fiber types in diaphragm, soleus, and EDL muscles manifested similar endotoxin-related reductions in Fmax. The Ca50 and the Hill coefficient for all fiber types and all muscles were unaffected by endotoxin administration. We speculate that these alterations in the intrinsic properties of the contractile proteins represent a major mechanism by which endotoxemia reduces muscle force-generating capacity.

Changes in the activities of protein kinases A,C, and M in dog heart and liver following endotoxin administration

Life Sciences ◽  
1994 ◽  
Vol 54 (16) ◽  
pp. 1163-1168 ◽  
Author(s):  
Hseng-Kuang Hsu ◽  
Yung-Ping Tao ◽  
Xiang-Yin Chen ◽  
Jun Huang ◽  
Maw-Shung Liu
Keyword(s):  
Protein Kinases ◽  
Endotoxin Administration ◽  
Dog Heart

Effects of dichloroacetate and naloxone on hemodynamic performance and substrate use following endotoxin administration

1988 ◽  
Vol 3 (2) ◽  
pp. 82-88 ◽  
Author(s):  
Mayer Sagy ◽  
David B. Swedlow ◽  
Deborah H. Schaible ◽  
Gary Fleisher
Keyword(s):  
Substrate Use ◽  
Endotoxin Administration ◽  
Hemodynamic Performance

Myocardial Performance and Adrenergic Modulation of Cyclic AMP Following Endotoxin Administration

1986 ◽  
pp. 171-185
Author(s):  
Raymond E. Shepherd ◽  
Charles H. Lang ◽  
Brent A. Brumfield ◽  
Norman W. Robie ◽  
Karen R. DuSapin ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Myocardial Performance ◽  
Endotoxin Administration ◽  
Adrenergic Modulation
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