scholarly journals Predictors of Recurrence in Hepatitis C Virus Related Hepatocellular Carcinoma after Hepatic Resection: A Retrospective Cohort Study

2014 ◽  
Vol 46 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Ahmed Shehta ◽  
Ayman El Nakeeb ◽  
Hosam Hamed ◽  
Mohamed Abdel Wahab ◽  
Tarek Salah
Transfusion ◽  
2018 ◽  
Vol 58 (12) ◽  
pp. 2880-2885 ◽  
Author(s):  
Shigeharu Uchida ◽  
Masahiro Satake ◽  
Akemi Kurisu ◽  
Aya Sugiyama ◽  
Ko Ko ◽  
...  

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e021747 ◽  
Author(s):  
Chien-Hsueh Tung ◽  
Ning-Sheng Lai ◽  
Chung-Yi Li ◽  
Shiang-Jiun Tsai ◽  
Yen-Chun Chen ◽  
...  

ObjectivesTo illuminate the association between interferon-based therapy (IBT) and the risk of rheumatoid arthritis (RA) in patients infected with hepatitis C virus (HCV).Design, setting, participants and interventionsThis retrospective cohort study used Taiwan’s Longitudinal Health Insurance Database 2005 that included 18 971 patients with HCV infection between 1 January 1997 and 31 December 2012. We identified 1966 patients with HCV infection who received IBT (treated cohort) and used 1:4 propensity score-matching to select 7864 counterpart controls who did not receive IBT (untreated cohort).Outcome measuresAll study participants were followed until the end of 2012 to calculate the incidence rate and risk of incident RA.ResultsDuring the study period, 305 RA events (3.1%) occurred. The incidence rate of RA was significantly lower in the treated cohort than the untreated cohort (4.0 compared with 5.5 per 1000 person-years, p<0.018), and the adjusted HR remained significant at 0.63 (95% CI 0.43 to 0.94, p=0.023) in a Cox proportional hazards regression model. Multivariate stratified analyses revealed that the attenuation in RA risk was greater in men (0.35; 0.15 to 0.81, p=0.014) and men<60 years (0.29; 0.09 to 0.93, p=0.036).ConclusionsThis study demonstrates that IBT may reduce the risk of RA and contributes to growing evidence that HCV infection may lead to development of RA.


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