scholarly journals The Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma as a Biological Marker for Predicting Mortality in Community-Acquired Pneumonia: A Cohort Study

2016 ◽  
Vol 15 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Manuel Antonio Tazón Varela ◽  
Pedro Muñoz Cacho ◽  
Héctor Alonso Valle ◽  
Jaime Gallo Terán ◽  
Luis Angel Pérez Mier ◽  
...  
Keyword(s):  
Cohort Study ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Biological Marker ◽  
Community Acquired Pneumonia ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

scholarly journals Amino-terminal fragment of the prohormone brain-type natriuretic peptide in rheumatoid arthritis

2008 ◽  
Vol 58 (9) ◽  
pp. 2662-2669 ◽  
Author(s):  
Joseph Solus ◽  
Cecilia P. Chung ◽  
Annette Oeser ◽  
Ingrid Avalos ◽  
Tebeb Gebretsadik ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Natriuretic Peptide ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

scholarly journals Correlation and Prognostic Utility of B-Type Natriuretic Peptide and Its Amino-Terminal Fragment in Patients With Chronic Kidney Disease

2006 ◽  
Vol 126 (4) ◽  
pp. 506-512 ◽  
Author(s):  
Wendy J. Austin ◽  
Vikas Bhalla ◽  
Israel Hernandez-Arce ◽  
Susan R. Isakson ◽  
Jennifer Beede ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Natriuretic Peptide ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Prognostic Utility ◽  
Amino Terminal Fragment

Plasma amino-terminal pro-brain natriuretic peptide: A novel approach to the diagnosis of cardiac dysfunction

2000 ◽  
Vol 6 (2) ◽  
pp. 130-139 ◽  
Author(s):  
Duncan J. Campbell ◽  
Kenneth I. Mitchelhill ◽  
Stephen M. Schlicht ◽  
Russell J. Booth
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiac Dysfunction ◽  
Amino Terminal ◽  
Novel Approach

scholarly journals Evolution of the hedgehog Gene Family

Genetics ◽  
1996 ◽  
Vol 142 (3) ◽  
pp. 965-972 ◽  
Author(s):  
Sudhir Kumar ◽  
Kristi A Balczarek ◽  
Zhi-Chun Lai
Keyword(s):  
Intercellular Communication ◽  
Short Range ◽  
Gene Duplications ◽  
Future Directions ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Carboxyl Terminal ◽  
Multicellular Organisms ◽  
Amino Terminal Fragment

Abstract Effective intercellular communication is an important feature in the development of multicellular organisms. Secreted hedgehog (hh) protein is essential for both long- and short-range cellular signaling required for body pattern formation in animals. In a molecular evolutionary study, we find that the vertebrate homologs of the Drosophila hh gene arose by two gene duplications: the first gave rise to Desert hh, whereas the second produced the Indian and Sonic hh genes. Both duplications occurred before the emergence of vertebrates and probably before the evolution of chordates. The amino-terminal fragment of the hh precursor, crucial in long- and short-range intercellular communication, evolves two to four times slower than the carboxyl-terminal fragment in both Drosophila hh and its vertebrate homologues, suggesting conservation of mechanism of hh action in animals. A majority of amino acid substitutions in the amino- and carboxyl-terminal fragments are conservative, but the carboxyl-terminal domain has undergone extensive insertion-deletion events while maintaining its autocleavage protease activity. Our results point to similarity of evolutionary constraints among sites of Drosophila and vertebrate hh homologs and suggest some future directions for understanding the role of hh genes in the evolution of developmental complexity in animals.

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