scholarly journals CT-guided 125I brachytherapy combined with chemotherapy for the treatment of unresectable or locally advanced pancreatic carcinoma

2020 ◽  
Author(s):  
Ma Luo ◽  
◽  
Jiawen Chen ◽  
Zhihui Zhong ◽  
Fujun Zhang ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Locally Advanced ◽  
Ct Guided ◽  
Locally Advanced Pancreatic Carcinoma ◽  
125I Brachytherapy ◽  
Advanced Pancreatic Carcinoma

scholarly journals Locally advanced pancreatic carcinoma with jaundice: the benefit of a sequential treatment with stenting followed by CT-guided 125I seeds implantation

2021 ◽  
Author(s):  
Chao Chen ◽  
Wei Wang ◽  
Wujie Wang ◽  
Yongzheng Wang ◽  
Zhe Yu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Obstructive Jaundice ◽  
Pancreatic Carcinoma ◽  
Locally Advanced ◽  
Biliary Stenting ◽  
Ct Guided ◽  
Seed Implantation ◽  
Locally Advanced Pancreatic Carcinoma ◽  
Advanced Pancreatic Carcinoma ◽  
Iodine 125

Abstract Objectives To evaluate the role of sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation for locally advanced pancreatic carcinoma with concomitant obstructive jaundice. Methods Between January 2016 and December 2018, 42 patients diagnosed with locally advanced pancreatic carcinoma with concomitant obstructive jaundice were enrolled retrospectively. All patients received biliary stenting via percutaneous transhepatic biliary drainage (PTBD) to alleviate obstructive jaundice. Thereafter, twenty-two patients underwent CT-guided iodine-125 seed implantation (treatment group), and 20 did not (control group). The prescribed dose in the treatment group was 110–130 Gy. The clinical data, duration of biliary stent patency, and overall survival (OS) were evaluated. Results Overall, the total bilirubin level decreased from 275.89 ± 115.44 to 43.08 ± 43.35 μmol/L (p < 0.001) 1 month after percutaneous biliary stenting. In the treatment group, the postoperative median dose covering 90% of the target volume was 129.71 Gy. Compared with the control group, the treatment group had a long mean duration of biliary stent patency and median OS (11.42 vs. 8.57 months, p < 0.01; 11.67 vs. 9.40 months, p < 0.01, respectively). The overall positive response rates 6 months post-treatment in the treatment and control groups were 72.7% (16/22) and 30% (6/20), respectively. Adverse events of more than grade 3 were not observed during the follow-up. Conclusion Sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation is an effective and safe treatment alternative for locally advanced pancreatic carcinoma with concomitant obstructive jaundice, which is worthy of clinical application. Key Points • Obstructive jaundice was alleviated after biliary stent placement in all patients, and the total bilirubin level decreased. • The overall positive response rates at 6 months post-treatment were higher in the treatment group than in the control group, and adverse events of more than grade 3 were not observed during the follow-up period. • Sequential therapy with percutaneous biliary stenting and CT-guided iodine-125 seed implantation can prolong biliary stent patency and improve survival.

Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma

2005 ◽  
Vol 76 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Morten Hoyer ◽  
Henrik Roed ◽  
Lisa Sengelov ◽  
Anders Traberg ◽  
Lars Ohlhuis ◽  
...  
Keyword(s):  
Pancreatic Carcinoma ◽  
Phase Ii ◽  
Stereotactic Radiotherapy ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Locally Advanced Pancreatic Carcinoma ◽  
Advanced Pancreatic Carcinoma
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