scholarly journals Evaluation of skeletal muscle perfusion in a canine hind limb ischemia model using CT perfusion imaging

2020 ◽  
Vol 26 (1) ◽  
pp. 28-33
Author(s):  
Tao Wang ◽  
◽  
Haobo Su ◽  
Jianping Gu ◽  
Qian Chen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Perfusion Imaging ◽  
Hind Limb ◽  
Ct Perfusion ◽  
Limb Ischemia ◽  
Muscle Perfusion ◽  
Hind Limb Ischemia ◽  
Ct Perfusion Imaging

scholarly journals Apolipoprotein E–/– mice have delayed skeletal muscle healing after hind limb ischemia–reperfusion

2008 ◽  
Vol 48 (3) ◽  
pp. 701-708 ◽  
Author(s):  
Jeanwan Kang ◽  
Hassan Albadawi ◽  
Virendra I. Patel ◽  
Thomas A. Abbruzzese ◽  
Jin-Hyung Yoo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Apolipoprotein E ◽  
Hind Limb ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Hind Limb Ischemia

scholarly journals p66ShcAand Oxidative Stress Modulate Myogenic Differentiation and Skeletal Muscle Regeneration after Hind Limb Ischemia

2007 ◽  
Vol 282 (43) ◽  
pp. 31453-31459 ◽  
Author(s):  
Germana Zaccagnini ◽  
Fabio Martelli ◽  
Alessandra Magenta ◽  
Chiara Cencioni ◽  
Pasquale Fasanaro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Hind Limb ◽  
Myogenic Differentiation ◽  
Limb Ischemia ◽  
Skeletal Muscle Regeneration ◽  
Hind Limb Ischemia

scholarly journals Effect of nerve growth factor dimeric mimetic GK-2 on microcirculation in skeletal muscle on the hind limb ischemia model in rats

2021 ◽  
pp. 9-13
Author(s):  
I. B. Tsorin ◽  
A. O. Efimova ◽  
E. S. Pekeldina ◽  
M. B. Vititnova ◽  
S. A. Kryzhanovskii
Keyword(s):  
Skeletal Muscle ◽  
Hind Limb ◽  
White Male ◽  
Limb Ischemia ◽  
Trka Receptor ◽  
Contralateral Limb ◽  
Hind Limb Ischemia ◽  
Artery Resection ◽  
Ischemic Muscle ◽  
Mimetic Compound

The purpose of the study. In experiments on a hind limb ischemia model in rats, the effect of the TrkA-receptor agonist of the NGF 4th loop dimeric dipeptide mimetic compound GK-2 has been studied on microcirculation in ischemic skeletal muscle.Methods. the Hind limb ischemia was caused in white male mongrel rats by the femoral artery resection. The compound GK-2 was administered intravenously (1 mg/kg/day during 14 days). Microcirculation parameters were recorded using a computer laser analyzer "LAKK-OP2". Registration was carried out simultaneously in the intact and operated limb before the operation, 1 and 14 days after it.Results. In the conditions of the hind limb ischemia model, it was shown that the compound GK-2 almost completely restored the perfusion index and its variation coefficient in the ischemic muscle to the intact contralateral limb level by the 14th day after surgery.Conclusion. It can be assumed that the anti-ischemic effect of the compound GK-2 is associated with the restoration of microcirculation as a result of increased neoangiogenesis.

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