scholarly journals Reproducibility and variability of very low dose hepatic perfusion CT in metastatic liver disease

2016 ◽  
Vol 22 (6) ◽  
pp. 495-500 ◽  
Author(s):  
Osman Melih Topcuoglu ◽  
Musturay Karcaaltincaba ◽  
Deniz Akata ◽  
Mustafa Nasuh Ozmen
Keyword(s):  
Liver Disease ◽  
Low Dose ◽  
Perfusion Ct ◽  
Hepatic Perfusion ◽  
Metastatic Liver

scholarly journals Interventional Oncology Approach to Hepatic Metastases

2020 ◽  
Vol 37 (05) ◽  
pp. 484-491
Author(s):  
Cathal O'Leary ◽  
Michael C. Soulen ◽  
Susan Shamimi-Noori
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Interventional Oncology ◽  
Hepatic Metastases ◽  
Locoregional Therapy ◽  
Treatment Modalities ◽  
Patient Specific ◽  
Curative Intent ◽  
Locoregional Therapies ◽  
Metastatic Liver

AbstractMetastatic liver disease is one of the major causes of cancer-related morbidity and mortality. Locoregional therapies offered by interventional oncologists alleviate cancer-related morbidity and in some cases improve survival. Locoregional therapies are often palliative in nature but occasionally can be used with curative intent. This review will discuss important factors to consider prior to palliative and curative intent treatment of metastatic liver disease with locoregional therapy. These factors include those specific to the tumor, liver function, liver reserve, differences between treatment modalities, and patient-specific considerations.

scholarly journals Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Robin Mesnage ◽  
George Renney ◽  
Gilles-Eric Séralini ◽  
Malcolm Ward ◽  
Michael N. Antoniou
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Low Dose ◽  
Daily Intake ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Metabolome Analysis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract The impairment of liver function by low environmentally relevant doses of glyphosate-based herbicides (GBH) is still a debatable and unresolved matter. Previously we have shown that rats administered for 2 years with 0.1 ppb (50 ng/L glyphosate equivalent dilution; 4 ng/kg body weight/day daily intake) of a Roundup GBH formulation showed signs of enhanced liver injury as indicated by anatomorphological, blood/urine biochemical changes and transcriptome profiling. Here we present a multiomic study combining metabolome and proteome liver analyses to obtain further insight into the Roundup-induced pathology. Proteins significantly disturbed (214 out of 1906 detected, q < 0.05) were involved in organonitrogen metabolism and fatty acid β-oxidation. Proteome disturbances reflected peroxisomal proliferation, steatosis and necrosis. The metabolome analysis (55 metabolites altered out of 673 detected, p < 0.05) confirmed lipotoxic conditions and oxidative stress by showing an activation of glutathione and ascorbate free radical scavenger systems. Additionally, we found metabolite alterations associated with hallmarks of hepatotoxicity such as γ-glutamyl dipeptides, acylcarnitines, and proline derivatives. Overall, metabolome and proteome disturbances showed a substantial overlap with biomarkers of non-alcoholic fatty liver disease and its progression to steatohepatosis and thus confirm liver functional dysfunction resulting from chronic ultra-low dose GBH exposure.

274 Neoadjuvant treatment of metastatic liver disease with raltitrexed and oxaliplatin in colorectal cancer patients

2003 ◽  
Vol 1 (5) ◽  
pp. S84
Author(s):  
F.R. Garcia-Arroyo ◽  
J.M. Garcia-Bueno ◽  
M. Constenia ◽  
C. Vadell ◽  
P. Palacios ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Disease ◽  
Cancer Patients ◽  
Neoadjuvant Treatment ◽  
Colorectal Cancer Patients ◽  
Metastatic Liver

Hepatic perfusion changes in an experimental model of acute pancreatitis: Evaluation by perfusion CT

2010 ◽  
Vol 75 (2) ◽  
pp. 203-206 ◽  
Author(s):  
Semra Tutcu ◽  
Selim Serter ◽  
Yavuz Kaya ◽  
Eray Kara ◽  
Nalan Neşe ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Experimental Model ◽  
Perfusion Ct ◽  
Hepatic Perfusion

scholarly journals Risk-adapted strategy partial liver irradiation for the treatment of large volume metastatic liver disease

2013 ◽  
Vol 53 (5) ◽  
pp. 702-706 ◽  
Author(s):  
Katharine L. Aitken ◽  
Diana M. Tait ◽  
Christopher M. Nutting ◽  
Komel Khabra ◽  
Maria A. Hawkins
Keyword(s):  
Liver Disease ◽  
Large Volume ◽  
Metastatic Liver

scholarly journals Metastatic Liver Disease - Presenting as Multiple Hepatic Cysts

2015 ◽  
Vol 1 (1) ◽  
pp. 11-13
Author(s):  
John D. Goodwin ◽  
◽  
Jason Schmidt ◽  
Parvez Mantry ◽  
◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatic Cysts ◽  
Metastatic Liver

scholarly journals Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Takahiro Kataoka ◽  
Kiyonori Yamaoka
Keyword(s):  
Liver Disease ◽  
Alloxan Diabetes ◽  
Low Dose ◽  
Oxygen Species ◽  
Sod Activity ◽  
Oxygen Stress ◽  
Dose Irradiation ◽  
Treatment Of Diabetes ◽  
Radon Inhalation ◽  
Nonalcoholic Liver Disease

Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose -irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or -irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl4) hepatopathy. Moreover, radon inhalation also inhibits CCl4-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.

The Use of Thermography in the Detection of Metastatic Liver Disease

Radiology ◽  
1970 ◽  
Vol 95 (3) ◽  
pp. 696-698 ◽  
Author(s):  
Carl M. Mansfield ◽  
Corinne Farrell ◽  
Sucha O. Asbell
Keyword(s):  
Liver Disease ◽  
Metastatic Liver
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