The Role of Serum Zinc Level in Febrile Convulsion Etiology

2012 ◽  
Vol 6 (3) ◽  
pp. 90-93 ◽  
Author(s):  
İhsan Kafadar ◽  
Ayşe Burcu Akıncı ◽  
Fügen Pekün ◽  
Erdal Adal
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsion ◽  
Zinc Level ◽  
Serum Zinc Level

scholarly journals Association of Serum Zinc Level with Febrile Seizures in Children

2021 ◽  
pp. 200-203
Author(s):  
Maryum Naveed ◽  
Rimsha Mohsin ◽  
Palwasha Khan
Keyword(s):  
Febrile Seizure ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

scholarly journals Regulatory Role of Zinc in Allergic Rhinitis through the IL-33/ST2 Pathway

2022 ◽  
Vol 2022 ◽  
pp. 1-6
Author(s):  
Wulin Wen ◽  
Fengxia Yang ◽  
Xueliang Shen ◽  
Ningyu Feng ◽  
Huiyu Ha ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Serum Zinc ◽  
Zinc Level ◽  
Cell Counting ◽  
Regulatory Role ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Zinc Level ◽  
Cell Supernatant

Objective. We aimed to investigate the expression of serum zinc and cytokines interleukin- (IL-) 13 and IL-33 in patients with allergic rhinitis (AR) and observe the effects of zinc on cytokines and pathway proteins in P815 mast cells stimulated by Artemisia annua allergen (Art.) in the IL-33/suppression of the tumorigenicity 2 (ST2) pathway. We also aimed to explore the possible regulatory role of zinc in AR and provide new ideas to determine the etiology and treatment of AR. Methods. AR patients treated from March to September in 2018 were selected as the research participants, and 50 healthy people in the same period were selected as the control group. Serum samples of all patients were collected, and those of AR patients were tested for the presence of allergens. The expression of IL-13 and IL-33 was detected by performing an enzyme-linked immunosorbent assay, while the serum zinc level was detected by conducting an inductively coupled plasma mass spectrometry. The cell counting kit (CCK-8) was used to detect the proliferation of P815 mast cells, and western blot was used to detect the expression of ST2, p38, and p65 proteins. Results. A total of 92 AR patients were included in the study; of them, 52 had mild AR, while 40 had moderate AR. The primary allergen found in AR patients was Artemisia, and the positivity rate was 53.26%. The serum zinc ion level of AR patients decreased, and the expression of IL-13 and IL-33 increased. After Art. was used to treat P815 mast cells, the expression of IL-33 in the cell supernatant increased in a concentration-dependent manner, the expression of receptor ST2 increased, and the expression of downstream p38 and p65 proteins increased. However, after treatment with ZnSO4, the expression of IL-33 in the cell supernatant decreased, and the expression of ST2, p38, and p65 protein decreased. Conclusion. The serum zinc level of AR patients decreased. In the IL-33/ST2 pathway, ZnSO4 can reduce the hypersensitivity of mast cells induced by Art.

Serum zinc level in Nigerian children with febrile convulsion

2015 ◽  
Vol 10 (03) ◽  
pp. 187-191
Author(s):  
Wilson Sadoh ◽  
Gabriel Ofovwe ◽  
Alphonsus Onyiriuka ◽  
Matthias Okposio
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsion ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Nigerian Children

scholarly journals TO STUDY SERUM ZINC LEVEL IN CHILDREN WITH FEBRILE SEIZURE.

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Deepak Choudhary ◽  
Sandeep Kulhari
Keyword(s):  
Case Control Study ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Zinc Level ◽  
Control Groups ◽  
Predisposing Factor ◽  
And Control ◽  
Control Study

Background: Febrile seizures are the most common cause of convulsions in children. However, the exact underlying etiology and the pathophysiological mechanisms are yet to be established. Various theories have been put forward regarding the role of trace elements as predisposing factors in causing the convulsions. Among them, Zinc is the most interesting trace element whose role in diarrhea and pneumonia is well proven. Methods: Hospital based Prospective, Analytical, Case – Control study conducted on 100 patients were enrolled in the study out of which 50 were cases which were febrile convulsion patients and 50 were control who were age and weight matched children. Results: Mean zinc level was 69.80±13.13mcg/dl and 80.76±10.24 mcg/dl in study and control groups respectively and this difference was found statistically highly significant (p<0.001). Conclusion- This study establishes a definite relationship between zinc deficiency and febrile seizures thereby substantiating zinc as an important predisposing factor in febrile seizures. Keywords: Zinc, Epilepsy, Deficiency

scholarly journals Role of Serum Zinc Level and P300 Event Related Potential in Detection of Minimal Hepatic Encephalopathy

2015 ◽  
Vol 05 (06) ◽  
pp. 58-65
Author(s):  
Ghada M. Galal ◽  
Mahmoud Saif-Al-Islam ◽  
Mohammed Abd Al-Ghafar Abd Al Rahman ◽  
Nagwa S. Ahmed ◽  
Mona M. Abd El Rhman
Keyword(s):  
Hepatic Encephalopathy ◽  
Serum Zinc ◽  
Minimal Hepatic Encephalopathy ◽  
Zinc Level ◽  
Event Related Potential ◽  
Serum Zinc Level ◽  
P300 Event Related Potential

scholarly journals Serum Zinc Level in Children With Febrile Convulsion

2016 ◽  
Vol In Press (InPress) ◽  
Author(s):  
Ali Khajeh ◽  
Ghasem Miri-Aliabad ◽  
Afshin Fayyazi ◽  
Zohreh Safdari ◽  
Maryam Keikha ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Febrile Convulsion ◽  
Zinc Level ◽  
Serum Zinc Level

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2077
Author(s):  
Jiun-Chi Huang ◽  
Ya-Chin Huang ◽  
Pei-Yu Wu ◽  
Wen-Hsien Lee ◽  
Yi-Chun Tsai ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Left Atrial Volume ◽  
Serum Zinc ◽  
Zinc Level ◽  
Volume Index ◽  
Serum Zinc Level ◽  
Lower Serum ◽  
Echocardiographic Parameters ◽  
Zinc Levels ◽  
Serum Zinc Levels

Diastolic dysfunction is an emerging challenge among hemodialysis (HD) patients, and the associations between serum zinc with echocardiographic parameters and diastolic function remain uncertain. A total of 185 maintenance HD patients were stratified by the tertiles of serum zinc level to compare their clinical characteristics and echocardiography. Correlations of serum zinc levels with echocardiographic parameters were examined using Pearson’s analysis. Univariate and multivariate logistic regression analyses were performed to investigate the determinants of E/e’ ratio >15 and left atrial volume index (LAVI) > 34 mL/m2, both indicators of diastolic dysfunction. Patients belonging to the first tertile of serum zinc level had a significantly higher E/e’ ratio and LAVI. Serum zinc levels were negatively correlated with E (r = −0.204, p = 0.005), E/e’ ratio (r = −0.217, p = 0.003), and LAVI (r = −0.197, p = 0.007). In a multivariate analysis, older age, diabetes, coronary artery disease, and lower serum zinc levels (OR = 0.974, 95% CI = 0.950–0.999, p = 0.039) were significantly associated with E/e’ ratio >15. Furthermore, diabetes and lower serum zinc levels (OR = 0.978, 95% CI = 0.958–0.999, p = 0.041) were significantly associated with LAVI >34 mL/m2. Reduced serum zinc level was significantly associated with diastolic dysfunction among HD patients. Further prospective studies are warranted to investigate whether zinc supplementation can attenuate cardiac dysfunction in maintenance HD patients.

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