scholarly journals Does the MTHFR C677T gene polymorphism indicate cardiovascular disease risk in type 2 diabetes mellitus patients?

2015 ◽  
Vol 15 (7) ◽  
pp. 524-530 ◽  
Author(s):  
Anzel Bahadir ◽  
Recep Eroz ◽  
Yasin Turker
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Mthfr C677t

Assessing 10-Year Cardiovascular Disease Risk in Malaysians With Type 2 Diabetes Mellitus: Framingham Cardiovascular Versus United Kingdom Prospective Diabetes Study Equations

2019 ◽  
Vol 31 (7) ◽  
pp. 622-632
Author(s):  
Sheng Qian Yew ◽  
Yook Chin Chia ◽  
Michael Theodorakis
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
United Kingdom ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cvd Risk ◽  
Fatal Stroke

In this study, we evaluated the performance of the Framingham cardiovascular disease (CVD) and the United Kingdom Prospective Diabetes Study (UKPDS) risk equations to predict the 10-year CVD risk among type 2 diabetes mellitus (T2DM) patients in Malaysia. T2DM patients (n = 660) were randomly selected, and their 10-year CVD risk was calculated using both the Framingham CVD and UKPDS risk equations. The performance of both equations was analyzed using discrimination and calibration analyses. The Framingham CVD, UKPDS coronary heart disease (CHD), UKPDS Fatal CHD, and UKPDS Stroke equations have moderate discrimination (area under the receiver operating characteristic [aROC] curve = 0.594-0.709). The UKPDS Fatal Stroke demonstrated a good discrimination (aROC curve = 0.841). The Framingham CVD, UKPDS Stroke, and UKPDS Fatal Stroke equations showed good calibration ( P = .129 to .710), while the UKPDS CHD and UKPDS Fatal CHD are poorly calibrated ( P = .035; P = .036). The UKPDS is a better prediction equation of the 10-year CVD risk among T2DM patients compared with the Framingham CVD equation.

Cardiovascular disease risk in subjects with type 2 diabetes mellitus in a population in southern Spain

2007 ◽  
Vol 76 (3) ◽  
pp. 436-444 ◽  
Author(s):  
Blanca Lahoz-Rallo ◽  
Manuel Blanco-Gonzalez ◽  
Inmaculada Casas-Ciria ◽  
Jose Alberto Marín-Andrade ◽  
Juan Carlos Mendez-Segovia ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Southern Spain
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