scholarly journals Assessment of the relationship between fragmented QRS and cardiac iron overload in patients with beta-thalassemia major

2015 ◽  
Vol 15 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Nermin Bayar ◽  
Erdal Kurtoglu ◽  
Sakir Arslan ◽  
Zehra Erkal ◽  
Serkan Cay ◽  
...  
Keyword(s):  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Fragmented Qrs ◽  
Beta Thalassemia Major ◽  
Cardiac Iron Overload ◽  
The Relationship

Assessment of the Relationship Between Iron Overload Based on Cardiac T2* MRI and Fragmented QRS in Beta-Thalassemia Major Patients

2020 ◽  
Vol 21 (8) ◽  
Author(s):  
Yazdan Ghandi ◽  
Danial Habibi ◽  
Aziz Eghbali
Keyword(s):  
Iron Overload ◽  
Chelation Therapy ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Fragmented Qrs ◽  
Beta Thalassemia Major ◽  
Cardiac Iron Overload ◽  
The Mean ◽  
T2 Mri

Background: Cardiac involvement in beta-thalassemia major patients is an important cause of mortality. Therefore, in these patients, timely diagnosis of cardiac disorder is essential. Objectives: The present study aimed at determining the association between cardiac iron overload and fragmented QRS (fQRS). Methods: This cross-sectional study was conducted on 40 β-TM patients, aged 5 - 40 years. The presence of fQRS was evaluated in 12-lead surface electrocardiograms. Cardiac T2* MRI was performed to determine the iron overload. The patients were divided into four groups of chelation therapy. Results: The mean age of patients was reported to be 22.50 ± 6.75 years. The groups showed no significant difference regarding gender, age, or left ventricular ejection fraction. The presence of fQRS was detected in 10 patients (25%), while T2* value was lower than 20 ms in 10 patients (25%). The mean age of patients with and without fQRS was 26.23 ± 2.71 and 19.40 ± 2.61 years, respectively (P = 0.001). The univariate analysis indicated that fQRS had a significant relationship with cardiac iron overload (OR = 5; 95% CI: 1.04 - 23.99; P < 0.044). The multiple logistic regression analysis represented a significant association between iron overload and fQRS (OR = 5.556; 95% CI: 1.027 - 30.049). The sensitivity and specificity of the fQRS against MRI were equal to 50% and 83.3% respectively. Conclusions: The absence of fQRS on ECGs could be a good predictor of the lack of cardiac iron overload in β-TM patients. The results showed that fQRS might indicate the no need for close monitoring for cardiac overload with cardiac MRI and aggressive chelation therapy.

GlutathioneS-transferase gene polymorphism: Relation to cardiac iron overload in Egyptian patients with Beta Thalassemia Major

Hematology ◽  
2015 ◽  
Vol 21 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Galila M. Mokhtar ◽  
Eman M. Sherif ◽  
Nevin M. Habeeb ◽  
Abeer A. Abdelmaksoud ◽  
Eman A. El-Ghoroury ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Beta Thalassemia Major ◽  
Transferase Gene ◽  
Egyptian Patients ◽  
Cardiac Iron Overload

The Effect of HFE Polymorphisms on Cardiac Iron Overload in Patients with Beta-Thalassemia Major

2013 ◽  
Vol 30 (8) ◽  
pp. 755-760 ◽  
Author(s):  
Aysen Turedi ◽  
Yesim Oymak ◽  
Timur Meşe ◽  
Yöntem Yaman ◽  
Selen Bayraktaroglu ◽  
...  
Keyword(s):  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Beta Thalassemia Major ◽  
Cardiac Iron Overload

scholarly journals SERUM FERRITIN AS A DIAGNOSTIC MARKER FOR CARDIAC IRON OVERLOAD AMONG BETA-THALASSEMIA MAJOR CHILDREN

2019 ◽  
Vol 6 (6) ◽  
pp. 269-272
Author(s):  
Subash Chandra Majhi ◽  
Nihar Ranjan Mishra ◽  
Prakash Chandra Panda ◽  
Sumeet Soumyaranjan Biswal
Keyword(s):  
Iron Overload ◽  
Serum Ferritin ◽  
Diagnostic Marker ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Beta Thalassemia Major ◽  
Cardiac Iron Overload

Evaluation of the relationship between hepatic and cardiac iron overload with MRI T2* and carotid intima media thickness with Doppler ultrasound in beta thalassemia major patients

2020 ◽  
Author(s):  
Reihaneh Mortazavi Ardestani ◽  
Masoud M. Ardestani
Keyword(s):  
Carotid Artery ◽  
Iron Overload ◽  
Doppler Ultrasound ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Beta Thalassemia ◽  
Control Group ◽  
Cardiac Iron ◽  
Cardiac Iron Overload ◽  
The Relationship

Background: Iron overload is caused early progression of atherosclerosis in beta thalassemia patients due to regular repeated blood transfusion. MRI T2* is a gold standard non-invasive method for detecting hepatic and cardiac iron overload. The aim of this study was the comparison of carotid intima media thickness (CIMT) in the patients and healthy control groups with Doppler ultrasound for early diagnosis of atherogenesis. Another purpose was to assess the relationship between CIMT and iron overload among patients. Materials and methods: This cross-sectional study was performed on twenty patients referred to the Sarvar clinic and twenty age- and sex-matched control group. The CIMT was measured with Color Doppler ultrasound in both groups. Then, MRI T2* results, demographic, and therapeutic information were extracted from their documents. Results: CIMT was insignificantly higher in the patients compared to the control group. For example, it was 0.49 ± 0.05 vs. 0.45 ± 0.03 (p = 0.009) for the right common carotid artery (RCCA) and 0.48 ± 0.06 vs. 0.46 ± 0.04 (p = 0.17) for the left common carotid artery (LCCA). There was no strong relationship between CIMT and age (p = 0.09 for RCCA, p = 0.00 for LCCA), sex, chelation type (for example, p = 0.51 for RCCA with Desferal and p = 0.91 for LCCA with Desferal), age at diagnosis, age at the beginning on transfusion (p = 0.49 for RCCA, p = 0.20 for LCCA), age at the start of chelator (p = 0.74 for RCCA, p = 0.78 for LCCA), and hepatic and cardiac iron overload. Conclusion: Preventive and curative methods should be planned to cease its progression. Furthermore, early initiation of chelator drugs with better efficacy and compliance may reverse the hepatotoxic and adverse myocardial effects of excessive iron.

No Correlation Between Myocardial T2* and Right Ventricular Function in Thalassemia Major. A Single Centre Four Years Experience

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 5308-5308
Author(s):  
Vassilios Perifanis ◽  
Efthimia Vlachaki ◽  
Nikolaos Neokleous ◽  
Aikaterini Teli ◽  
Antonia Kondou ◽  
...  
Keyword(s):  
Iron Overload ◽  
Right Ventricular ◽  
Ventricular Function ◽  
Right Ventricular Function ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Entire Group ◽  
Time Points ◽  
Cardiac Iron ◽  
Beta Thalassemia Major

Abstract Abstract 5308 Iron overload in the myocardium causes cardiomyopathy and increases the mortality of the transfusion-dependent patients with beta-thalassemia major. Myocardial T2* magnetic resonance imaging (MRI) provides a rapid and reproducible measure of cardiac iron loading and is being increasingly used worldwide for monitoring of transfusion-dependent thalassemia patients. Recent studies associate myocardial siderosis (T2* < 20 ms) with left ventricular (LV) dysfunction. However its relation with the right ventricular (RV) dysfunction has not yet been fully addressed. The aim of this study is to compare the relationship between cardiac T2* and RV function in transfusion-dependent beta-thalassemia major patients treated in a single institution in two different time points four years apart. Patients and Methods: Hundred patients (55 men; mean age, 25.8 ± 8,28 years) systematically transfused and iron chelated with different regimens were enrolled in the study. All MRI scans were performed at the beginning of the study and 4 years later. Each scan, acquired with an imager equipped with a 1.5 T magnet, included the measurement of heart T2* (mid-septum) together with LV and RV volumes, ejection fraction (EF ) and mass using previously published techniques. Results :Mean ferritin, mean T2* and mean RVEF at baseline was 1517 ± 1117 ng/ml, 33,39 ± 15,6 ms and 68 ± 5,37% respectively. There was no evident correlation between T2* and RVEF for the entire group as well as for the group with abnormal T2*. Four years later the T2* MRI was 36,64 ± 14,46 % ms expressing a statistical significant change (p<0.05). Mean ferritin and mean RVEF was 1275 ± 1045 ng/ml and 67,4±8,3% respectively. There was no other significant correlation between T2* and RESV, REDV for the entire group in the checked time points. At the beginning of the study, 20 out of the 100 patients had a T2* measurement below 20ms. At the end of the study 11 patients continued to have abnormal T2*.Four of the responders were treated with Deferiprone (out of 5), two with Deferasirox (out of 4) and three out of 5 with combination therapy (Desferrioxamine and deferiprone). All 6 patients treated with Desferrioxamine remained abnormal, although with better T2* measurements. Although there was a significant change in T2* measurements (p=0,018) in the group with abnormal T2*, RVEF did not show equally alteration. Conclusions: Myocardial iron deposition by MRI does not seem to be associated with RV dysfunction. The number of responders was too small to allow conclusions for most effective therapy. The only limitation of our study is that in contrast with other reports the percentage of patients with abnormal T2* was smaller (20%). Larger studies are required to determine the relation of right ventricular function and cardiac iron overload. Disclosures: Vlachaki: Novartis Hellas S.A.C.I.:. Oikonomou:Novartis Hellas S.A.C.I.:.

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