scholarly journals Correlation of cox- 2 expression in colorectal carcinoma with clinicopathological features

2017 ◽  
Author(s):  
Sandhya Venkatachala ◽  
Manjula Rajendran
Keyword(s):  
Colorectal Carcinoma ◽  
Clinicopathological Features ◽  
Cox 2

Expression of long non-coding RNA CCHE1 in colorectal carcinoma: correlations with clinicopathological features and ERK/COX-2 pathway

2018 ◽  
Vol 46 (1) ◽  
pp. 657-667 ◽  
Author(s):  
Hanaa H. Gaballah ◽  
Rasha A. Gaber ◽  
Mohamed A. Elrashidy ◽  
Dina A. Elshahat ◽  
Mohamed A. Hablus ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Clinicopathological Features ◽  
Non Coding Rna ◽  
Cox 2 ◽  
Long Non Coding Rna

scholarly journals EZH2 Expression and its Correlation with Clinicopathological Features in Patients with Colorectal Carcinoma

2016 ◽  
Vol 11 (1) ◽  
pp. 287-292
Author(s):  
Xiao-yang Liu ◽  
Hua Liu ◽  
Lin Gu ◽  
Hai-lun Zheng
Keyword(s):  
Colorectal Cancer ◽  
Colorectal Carcinoma ◽  
Disease Progression ◽  
Western Blotting ◽  
Progression Free Survival ◽  
Clinicopathological Features ◽  
Tumor Biomarker ◽  
Ezh2 Expression ◽  
Significant Difference ◽  
Colorectal Cancer Patients

AbstractObjectiveTo explore the correlation between the enhancer of zeste homolog 2 (EZH2) expression and clinicopathological features in colorectal cancer patients.MethodsA total of sixty-six patients with colorectal carcinoma were admitted to our general surgery department from January 2011 to December 2014. The EZH2 expression levels in the cancer tissues (CTs) from the 66 patients with colorectal cancer and those in distant normal colorectal tissues from 30 cases were examined through immunohistochemistry and western blotting assays. The relationship between the expression of EZH2 and the clinicopathological features and prognosis of the patients was analyzed.ResultsEZH2 in colorectal carcinoma tissues is granularly brown, predominantly expressed and diffused in the nuclei of tumor cells. Positive rates of EZH2 in intestinal CTs and in distant normal intestinal tissues are 62.12% (41/66) and 6.67% (2/30), respectively with significant difference (P < 0.05). Western blotting also confirmed its elevated expression in colorectal CTs. EZH2-positive expression in CTs was related to degree of differentiation, Duke staging, and tumor size (P < 0.05) but was unrelated to the patient’s gender, age or tumor site (P = 0.05). The 3-year progression-free survival (PFS) rates of the EZH2-positive group and the EZH2-negative group were 43.8% and 67.5%, respectively. The risk of disease progression of the EZH2-positive patients in the follow-up period was significantly higher than that of the EZH2-negative patients (HR = 2.49, 95% CI = 1.04–4.80, P < 0.05).ConclusionEZH2 is closely related to colorectal carcinoma development and disease progression, and thus could be used as a tumor biomarker that may indicate prognosis.

scholarly journals Clinicopathological Features of Serrated Adenocarcinoma Defined by Mäkinen in Dukes’ B Colorectal Carcinoma

Pathobiology ◽  
2012 ◽  
Vol 79 (4) ◽  
pp. 169-174 ◽  
Author(s):  
Yosuke Shida ◽  
Takahiro Fujimori ◽  
Hiroyuki Tanaka ◽  
Yukari Fujimori ◽  
Ryusuke Kimura ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Clinicopathological Features ◽  
Serrated Adenocarcinoma

Abstract C34: The role of COX-2/PGE2 in gossypol-induced apoptosis of colorectal carcinoma cells

2011 ◽  
Author(s):  
Yen-Chou Chen ◽  
Ching Huai Ko ◽  
Shing Chuan Shen ◽  
Liang Yo Yang
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Cox 2 ◽  
Induced Apoptosis

Effect of PPAR activators on cytokine-stimulated COX-2 induction in human colorectal carcinoma cells

1999 ◽  
Vol 59 (1-6) ◽  
pp. 148
Author(s):  
Hiroshi Ikawa ◽  
Seung Joon Baek ◽  
Hideki Kamitani ◽  
Hideto Kameda ◽  
Thomas E. Eling ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma ◽  
Cox 2

Cytoplasmic expression of HuR and cyclooxygenase-2 expression in colon cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e22161-e22161
Author(s):  
J. Song ◽  
S. Choi ◽  
J. Lee ◽  
S. Lim
Keyword(s):  
Colorectal Carcinoma ◽  
Lymphatic Invasion ◽  
Cyclooxygenase 2 ◽  
Clinicopathological Parameters ◽  
Cytoplasmic Expression ◽  
Node Metastasis ◽  
Embryonic Lethal ◽  
Cox 2 ◽  
Colorectal Cancer Patients ◽  
Human Family

e22161 Background: HuR, human family embryonic-lethal abnormal vision-like protein, can bind to mRNAs and stabilizes them in the cytoplasm, resulting in more efficient translation. HuR is predominantly present in the nucleus and shuttles between the nucleus and cytoplasm. The mRNA of cyclooxygenase-2 (Cox-2) is stabilized by HuR in several cancers, including breast, stomach, lung and brain. Methods: We investigated the expression and its cellular location of HuR, and Cox-2 expression in 79 colorectal cancer patients with immunohistochemistry, and evaluated the biological implications in colorectal carcinoma. Results: Nuclear HuR expression was observed in 59 (74.7%) and cytoplasmic HuR expression was seen in 25 (31.6%). Cox-2 immunoreactivity was noted in 42 (53%). The expression of cytoplasmic HuR was significantly associated with Cox-2 expression (p=0.004). And cytoplasmic expression of HuR showed correlation with lymphatic invasion (p=0.025) and lymph node metastasis (p=0.027). Nuclear HuR showed no correlation with Cox-2 expression or other clinicopathological parameters examined. Conclusions: These results suggest that cytoplasmic translocation of HuR is associated with Cox-2 expression in some colorectal carcinoma. No significant financial relationships to disclose.

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