scholarly journals Prominent signet ring cell morphology in a pulmonary squamous cell carcinoma

2015 ◽  
Author(s):  
Nuri Yigit ◽  
Ertugrul Celik ◽  
Ibrahim Yavan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Morphology ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Synchronous Signet Ring Cell Carcinoma and Squamous Cell Carcinoma Arising in an Augmented lleocystoplasty

1996 ◽  
Vol 29 (1) ◽  
pp. 125-128 ◽  
Author(s):  
M. Fernandez-Arjona ◽  
L. Herrero ◽  
J.C. Romero ◽  
S. Nieto ◽  
R. Martin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Cutaneous signet-ring cell squamous cell carcinoma

2020 ◽  
Vol 33 (3) ◽  
pp. 424-426
Author(s):  
Sarah K. Findeis ◽  
Allison Readinger ◽  
James Mitchell ◽  
Atin Agarwal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Basal cell carcinoma with signet ring cell morphology accumulating the ubiquitinated cytokeratin 5/6

2021 ◽  
Vol 14 (4) ◽  
pp. e241993
Author(s):  
Ayako Watanabe ◽  
Naoshige Iida ◽  
Katsuhiko Enomoto
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cell Morphology ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Cytokeratin 5 ◽  
Ubiquitin Proteasome ◽  
Ring Cell ◽  
The Right

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Inside of the cancer islands, many tumour cells showed an enlarged fine granular cytoplasm with the peripherally compressed nuclei, being similar to the SR cell. Immunohistochemical examination revealed dense accumulation of cytokeratin (CK) 5/6 and a faint signal of 34βE12 in SR cells. The reported myoepithelial markers were not detected. Interestingly, ubiquitin, a component of the ubiquitin–proteasome protein degradation system, was co-localised in the SR cells. These suggest, for the first time, that accumulation of the undegraded CK5/6 with ubiquitination results in the SR cell morphology. Our report showed that the aberrant keratin turnover is associated with the SR cell BCC.

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