Evaluation of toll-like receptor 4 polymorphism in patients with hepatitis c virus-induced hepatocellular carcinoma

2021 ◽  
Vol 30 (3) ◽  
pp. 1-8
Author(s):  
Fatma O. Khalil ◽  
Mohammed A. Rady ◽  
Seham A. Eissa ◽  
Azza M. Abd El Aziz
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protective Role ◽  
Control Group ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Development Methodology ◽  
Pathogen Recognition Receptors ◽  
Chronic Hcv ◽  
Tlr4 Receptor

Background: Liver related pathologies including Hepatocellular Carcinoma (HCC) is a universal problem. Innate immunity receptors were accused in the etiopathogenesis of HCC with many conflicts. TLR4 is one of pathogen recognition receptors involved in the pathogenesis of many diseases and malignancies. TLR4 receptor polymorphisms were investigated in HCV related morbidities along with inconclusive results Objectives: to study the role of TLR4 rs 2149356 and rs 1927914 genotypes polymorphisms in HCV related HCC development. Methodology: 200 Chronically infected HCV patients were enrolled in this study. they were divided according to lab and clinical data into 100 CHC group and 100 HCC patients who were compared to health individual. The blood samples obtained were further proceed to full lab and TLR4 genotyping by RFLP-PCR technique Results: GT genotype and T allele of TLR4 rs 2149356 at 95% CI of 0.38 (0.21-0.70) was significantly increased in control group than in HCC and CHC groups. At 0.32(0.17-0.63) TLR4 rs 1927914 C allele and CT genotype was significantly increased in Controls than diseased groups while T allele is significantly increased in HCC than control group. Conclusions: TLR4 genotypes may play a protective role against HCC development among chronic HCV patients.

scholarly journals Protective role of Toll-like receptor 4 in experimental gonococcal infection of female mice

2011 ◽  
Vol 5 (1) ◽  
pp. 19-29 ◽  
Author(s):  
M Packiam ◽  
H Wu ◽  
S J Veit ◽  
N Mavrogiorgos ◽  
A E Jerse ◽  
...  
Keyword(s):  
Protective Role ◽  
Toll Like Receptor ◽  
Gonococcal Infection ◽  
Toll Like Receptor 4 ◽  
Female Mice

scholarly journals Astragaloside IV alleviates placental oxidative stress and inflammation in GDM mice

2020 ◽  
Vol 9 (9) ◽  
pp. 939-945
Author(s):  
Ling Zhou ◽  
Ruixue Zhang ◽  
Shuangyan Yang ◽  
Yaguang Zhang ◽  
Dandan Shi
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Cytokines ◽  
Protective Role ◽  
The Other ◽  
Toll Like Receptor ◽  
Astragaloside Iv ◽  
Toll Like Receptor 4 ◽  
Pregnant Mice ◽  
Placental Oxidative Stress

Background: Our previous study revealed that astragaloside IV (AS-IV) effectively improved gestational diabetes mellitus (GDM) by reducing hepatic gluconeogenesis. Due to the importance of placental oxidative stress, we further explored the protective role of AS-IV on placental oxidative stress in GDM. Methods: First, non-pregnant mice were orally administrated with AS-IV to evaluate its safety and effect. Then GDM mice were orally administered with AS-IV for 20 days and its effect on the symptoms of GDM, placental oxidative stress, secretions of inflammatory cytokines, as well as toll-like receptor 4 (TLR4)/NF-κB signaling pathway, were evaluated. Results: AS-IV had no adverse effect on non-pregnant mice. On the other hand, AS-IV significantly attenuated the GDM-induced hyperglycemia, glucose intolerance, insulin resistance, placental oxidative stress, productions of inflammatory cytokines and the activation of TLR4/NF-κB pathway. Conclusion: AS-IV effectively protected against GDM by alleviating placental oxidative stress and inflammation, in which TLR4/NF-κB might be involved.

The Protective Role of Host Toll-Like Receptor-4 in Acute Graft-Versus-Host Disease

2010 ◽  
Vol 90 (10) ◽  
pp. 1063-1070 ◽  
Author(s):  
Takehito Imado ◽  
Tsuyoshi Iwasaki ◽  
Sachie Kitano ◽  
Atsushi Satake ◽  
Takanori Kuroiwa ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Protective Role ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Host Disease ◽  
Graft Versus Host ◽  
Acute Graft

scholarly journals Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis

2008 ◽  
Vol 68 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Nabiha Yusuf ◽  
Tahseen H. Nasti ◽  
J. Alan Long ◽  
Mohammed Naseemuddin ◽  
Alan P. Lucas ◽  
...  
Keyword(s):  
Chemical Carcinogenesis ◽  
Protective Role ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Initiation Stage

Association of the CD14 C159T and the Toll-like receptor 4 Asp299Gly polymorphisms with various phenotypes of asthma in adults from Crimea

2020 ◽  
Vol 41 (2) ◽  
pp. 134-140
Author(s):  
Yuriy Bisyuk ◽  
Andrew Dubovyi ◽  
Ilona DuBuske ◽  
Viktor Litus ◽  
Lawrence M. DuBuske
Keyword(s):  
Late Onset ◽  
Adult Population ◽  
Additive Models ◽  
Atopic Asthma ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Single Nucleotide ◽  
Gender And Age

Background: This study assessed gene polymorphisms of the CD14 receptor (C-159T) and Toll-like receptor 4 (Asp299Gly) in a patient population in Crimea, Ukraine, stratified by clinical (early versus late onset; frequent versus occasional relapses; fixed versus reversible obstruction) and immunologic (atopic versus nonatopic; eosinophilic; neutrophilic or paucigranulocytic inflammation) subtype. Methods: Two polymorphisms, CD14 C-159T and TLR4 Asp299Gly, were assessed in 331 patients with asthma. The control group included 285 volunteers who were nonatopic. The single nucleotide polymorphisms were studied by using polymerase chain reaction with electrophoretic detection. Results: There were increased odds of asthma development in patients with the Asp299Gly TLR4 mutation compared with the general population underdominant odds ratio (OR) 1.52 [95% confidence interval (CI), 1.00‐2.32] and overdominant (OR 1.55 [95% CI, 1.01‐2.38]) models after adjustment for gender and age. In addition, mutations in this gene decreased the odds of nonatopic asthma in underdominant (OR 0.26 [95% CI, 0.07‐0.93]; p = 0.027), overdominant (OR 0.27 [95% CI, 0.07‐0.96]; p = 0.033), and log-additive models (OR 0.26 [95% CI, 0.07‐0.93]; p = 0.026) compared with the atopic subgroup after adjustment for gender, age, number of exacerbations, and type of airway inflammation. Allele frequencies for CD14 and TLR4 polymorphisms did not show statistical differences between the patients with asthma and the control subjects. Conclusion: CD14 C-159T polymorphisms were not associated with asthma in the adult population in Crimea. TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.

Sign in / Sign up

Export Citation Format

Share Document