scholarly journals Protective Effect of Processed Panax ginseng, Sun Ginseng on UVB-irradiated Human Skin Keratinocyte and Human Dermal Fibroblast

2012 ◽  
Vol 36 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Hye-Jin Lee ◽  
Joo-Yeop Lee ◽  
Kyu-Choon Song ◽  
Jin-Hee Kim ◽  
Jeong-Hill Park ◽  
...  
Keyword(s):  
Protective Effect ◽  
Human Skin ◽  
Panax Ginseng ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast

scholarly journals Protocatechuic Aldehyde Attenuates UVA-induced Photoaging in Human Dermal Fibroblast Cells by Suppressing MAPKs/AP-1 and NF-κB Signaling Pathways

2020 ◽  
Vol 21 (13) ◽  
pp. 4619
Author(s):  
Yuling Ding ◽  
Chanipa Jiratchayamaethasakul ◽  
Seung-Hong Lee
Keyword(s):  
Nitric Oxide ◽  
Protective Effect ◽  
Signaling Pathways ◽  
Inflammatory Responses ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast ◽  
Potential Candidate ◽  
Ros Scavenging ◽  
Protocatechuic Aldehyde ◽  
Hdf Cells

Ultraviolet radiation (UV) is a major causative factor of DNA damage, inflammatory responses, reactive oxygen species (ROS) generation and a turnover of various cutaneous lesions resulting in skin photoaging. The purpose of this study is to investigate the protective effect of protocatechuic aldehyde (PA), which is a nature-derived compound, against UVA-induced photoaging by using human dermal fibroblast (HDF) cells. In this study, our results indicated that PA significantly reduced the levels of intracellular ROS, nitric oxide (NO), and prostaglandins-E2 (PGE2) in UVA-irradiated HDF cells. It also inhibited the levels of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. Besides, PA significantly suppressed the expression of matrix metalloproteinases-1 (MMP-1) and pro-inflammatory cytokines and promoted collagen synthesis in the UVA-irradiated HDF cells. These events occurred through the regulation of activator protein 1 (AP-1), nuclear factor-κB (NF-κB), and p38 signaling pathways in UVA-irradiated HDF cells. Our findings suggest that PA enhances the protective effect of UVA-irradiated photoaging, which is associated with ROS scavenging, anti-wrinkle, and anti-inflammatory activities. Therefore, PA can be a potential candidate for the provision of a protective effect against UVA-stimulated photoaging in the pharmaceutical and cosmeceutical industries.

Skin UV-protective effect of Microsorum grossum extract on human dermal fibroblast

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
P Raharivelomanana ◽  
R Ho ◽  
T Teai ◽  
A Meybeck
Keyword(s):  
Protective Effect ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast

scholarly journals Protective effect of oat bran extracts on human dermal fibroblast injury induced by hydrogen peroxide

2013 ◽  
Vol 14 (2) ◽  
pp. 97-105 ◽  
Author(s):  
Bing Feng ◽  
Lai-ji Ma ◽  
Jin-jing Yao ◽  
Yun Fang ◽  
Yan-ai Mei ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast ◽  
Oat Bran

scholarly journals Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes

2014 ◽  
Vol 33 (3) ◽  
pp. 640-648 ◽  
Author(s):  
GHANG TAI LEE ◽  
HWA JUN CHA ◽  
KWANG SIK LEE ◽  
KUN KOOK LEE ◽  
JIN TAE HONG ◽  
...  
Keyword(s):  
Protective Effect ◽  
Dermal Fibroblast ◽  
Human Dermal Fibroblast ◽  
Microrna Expression ◽  
Fibroblast Cells

scholarly journals Poly- and Oligosaccharide Ulva sp. Fractions from Enzyme-Assisted Extraction Modulate the Metabolism of Extracellular Matrix in Human Skin Fibroblasts: Potential in Anti-Aging Dermo-Cosmetic Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 156
Author(s):  
Mathilde Fournière ◽  
Gilles Bedoux ◽  
Nicolas Lebonvallet ◽  
Raphaël Leschiera ◽  
Claudie Le Goff-Pain ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Human Skin ◽  
Dermal Fibroblast ◽  
Biological Activities ◽  
Human Dermal Fibroblast ◽  
Dermal Fibroblasts ◽  
Normal Human Skin ◽  
Matrix Metalloproteinase 1 ◽  
Assisted Extraction ◽  
Enzyme Assisted Extraction

Ulva sp. is known to be a source of bioactive compounds such as ulvans, but their biological activity on human dermal fibroblast extracellular matrix (ECM) is poorly reported. In this work, the regulation of ECM has been investigated for the first time at both proteomic and transcriptomic levels in normal human skin dermal fibroblasts, after 48 h of incubation with poly- and oligosaccharide fractions from Ulva sp. obtained after enzyme-assisted extraction and depolymerization. Cell proliferation enhancement (up to +68%) without exhibiting any cytotoxic effect on fibroblasts was demonstrated at 50 and 1000 µg/mL by both fractions. At the proteomic level, polysaccharide fractions at 1000 µg/mL enhanced the most the synthesis of glycosaminoglycans (GAGs, up to +57%), total collagen, especially types I (up to +217%) and III, as well as the synthesis and activity of MMP-1 (Matrix Metalloproteinase-1, up to +309%). In contrast, oligosaccharide fractions had no effect on GAGs synthesis but exhibited similarities for collagens and MMP-1 regulation. At the transcriptomic level, the decrease of COL1A1 and COL1A2 expression, and increase of COL3A1 and MMP-1 expression, confirmed the modulation of ECM metabolism by both fractions. Our research emphasizes that poly- and oligosaccharide Ulva sp. fractions exhibit interesting biological activities and supports their potential use in the area of skin renewal for anti-aging dermo-cosmetic applications.

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