scholarly journals Up-regulation of Heme Oxygenase-1 by Korean Red Ginseng Water Extract as a Cytoprotective Effect in Human Endothelial Cells

2011 ◽  
Vol 35 (3) ◽  
pp. 352-359 ◽  
Author(s):  
Ha-Na Yang ◽  
Seung-Eun Lee ◽  
Seong-Il Jeong ◽  
Cheung-Seog Park ◽  
Young-Ho Jin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Heme Oxygenase ◽  
Water Extract ◽  
Heme Oxygenase 1 ◽  
Red Ginseng ◽  
Human Endothelial Cells ◽  
Cytoprotective Effect ◽  
Korean Red Ginseng

scholarly journals NO Modulates NADPH Oxidase Function Via Heme Oxygenase-1 in Human Endothelial Cells

Hypertension ◽  
2006 ◽  
Vol 48 (5) ◽  
pp. 950-957 ◽  
Author(s):  
Fan Jiang ◽  
Sarah J. Roberts ◽  
Srinivasa raju Datla ◽  
Gregory J. Dusting
Keyword(s):  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

Nitric oxide mediates NADPH oxidase function via heme oxygenase-1 in human endothelial cells

2006 ◽  
Vol 45 (3) ◽  
pp. e78
Author(s):  
Fan Jiang ◽  
Sarah J. Roberts ◽  
Srinivasa Raju Datla ◽  
Gregory J. Dusting
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nadph Oxidase ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

scholarly journals Induction of heme oxygenase 1 by arsenite inhibits cytokine-induced monocyte adhesion to human endothelial cells

2009 ◽  
Vol 236 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Xi Sun ◽  
Jingbo Pi ◽  
Wenlan Liu ◽  
Laurie G. Hudson ◽  
Ke Jian Liu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Monocyte Adhesion ◽  
Human Endothelial Cells

Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1

2008 ◽  
Vol 591 (1-3) ◽  
pp. 28-35 ◽  
Author(s):  
Xinyu Wang ◽  
Salomon Stavchansky ◽  
Baiteng Zhao ◽  
James A. Bynum ◽  
Sean M. Kerwin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Caffeic Acid ◽  
Heme Oxygenase ◽  
Caffeic Acid Phenethyl Ester ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

scholarly journals Dopamine induces the expression of heme oxygenase-1 by human endothelial cells in vitro

2000 ◽  
Vol 58 (6) ◽  
pp. 2314-2319 ◽  
Author(s):  
Stefan P. Berger ◽  
Mathias Hünger ◽  
Benito A. Yard ◽  
Peter Schnuelle ◽  
Fokko J. Van Der Woude
Keyword(s):  
Endothelial Cells ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Human Endothelial Cells

scholarly journals Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hye Rim Park ◽  
Seung Eun Lee ◽  
Hana Yang ◽  
Gun Woo Son ◽  
Young-Ho Jin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Death ◽  
Umbilical Vein ◽  
Water Extract ◽  
Thioredoxin Reductase ◽  
Vascular Diseases ◽  
Protective Effects ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Thioredoxin Reductase 1

Korean Red Ginseng is a popular herbal medicine and is widely used in many food products. KRG has biological benefits related to vascular diseases including diabetes, hypertension, atherosclerosis, and other cardiac diseases and KRG has antioxidant and anti-hyperlipidemic actions. KRG decreases the level of oxidative stress and suppresses proinflammatory cytokines and cell adhesion molecules, thus protecting endothelial dysfunction. Mammalian Thioredoxin reductase 1 is an NADPH-dependent selenoprotein, essential for antioxidant defense and DNA synthesis and repair, that regulates the redox system by modulating redox-sensitive transcription factors and thiol-containing proteins. Here, we show that KRG water extract increases the expression of TrxR1 in human umbilical vein endothelial cells via the p38 and PKC-δsignaling pathways. The induction of TrxR1 expression by KRG was confirmed by Western blot analysis and reverse transcription polymerase chain reaction. However, the increase in TrxR1 expression was abolished by specific silencing of the p38 and PKC-δgenes. In addition, we demonstrated that auranofin, a TrxR1 inhibitor, weakens the protective effect of KRG against H2O2-induced cell death as measured by the terminal transferase dUTP nick end labeling assay. These results suggest that KRG may have protective effects in vascular diseases by upregulating TrxR1 in endothelial cells, thereby inhibiting the generation of reactive oxygen species and cell death.

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