scholarly journals Cardioprotective and antioxidant effects of Bougainvillea glabra against isoproterenol induced myocardial necrosis in albino rats

2018 ◽  
Vol 10 (1) ◽  
pp. 45
Author(s):  
Rakam Gopi Krishna ◽  
Raja Sundara Rajan
Keyword(s):  
Methanol Extract ◽  
Myocardial Necrosis ◽  
Heart Tissue ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Antioxidant Parameters ◽  
Serum Glutamate ◽  
Bougainvillea Glabra

<p>The present study was executed to evaluate the myocardial protective effect of methanol extract of <em>Bougainvillea glabra </em>against isoproterenol induced myocardial necrosis in rats. Myocardial necrosis was induced by subcutaneous injection of isoproterenol (85mg/kg body weight) on 29<sup>th</sup> and 30<sup>th</sup> day at an interval of 24 hours. Myocardial necrosis was evident from the changes of marker enzymes in serum, plasma and heart tissue. The activities of serum cardiac marker enzymes such as lactate dehydrogenase (LDH), creatine kinase myoglobin (CK-MB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), triglycerides (TG), total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoproteins (VLDL) and total protein (TP) were estimated. In addition, plasma TBARS and plasma LDH levels were also recorded. Antioxidant parameters viz catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx) and malondialdehyde (MDA) levels were performed in heart tissue homogenate. The outcome of the study indicated that, pretreatment with methanol extract of <em>Bougainvillea glabra</em> to isoproterenol induced rats significantly prevented the altered serum cardiac marker enzymes, plasma levels and antioxidant parameters to near normal status. The cardioprotective effect was compared with propranolol (10 mg/kg, oral) which was used as the standard. Histopathological findings exposed a reduced degree of necrosis and inflammation succeeding pretreatment with <em>Bougainvillea glabra.</em>Based on these results, it was suggested that methanol extract of <em>Bougainvillea glabra</em> prevents myocardial necrosis and oxidative stress induced by isoproterenol.</p>

scholarly journals Cardioprotective Potential of Methanol Extract of Polygonum glabrum on Isoproterenol Induced Myocardial Necrosis in Rats

2017 ◽  
Vol 9 (3) ◽  
pp. 518
Author(s):  
Raja S ◽  
Ramya I
Keyword(s):  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Myocardial Necrosis ◽  
Tissue Homogenate ◽  
Low Density ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Serum Glutamate

<p>Aim: The aim of present study was to evaluate the cardioprotective efficacy of <em>Polygonum glabrum</em> on isoproterenol induced myocardial necrosis in rats. Methods: Experimental rats were treated orally with methanol extract of <em>Polygonum glabrum</em> at two doses (200 mg and 400 mg/kg) for 30 days. Isoproterenol (85 mg/kg, s.c.) was administered on 29<sup>th</sup> and 30<sup>th</sup> day to induce myocardial necrosis.  At the end of the experiment, serum cardiac marker enzymes [creatine kinase muscle brain (CK-MB), lactate dehydrogenase (LDH), serum glutamate oxaloacetate transaminase (SGOT)], serum glutamate pyruvate transaminase (SGPT) and total protein (TP) were estimated. Plasma total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels were also recorded. Further, antioxidant parameters viz catalase (CAT), superoxide dismutase (SOD),  glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels were evaluated in heart tissue homogenate. Results: The results of the study indicated that, methanol extract of <em>Polygonum glabrum</em> showed greater cardioprotection by restoring the cardiac marker enzymes and attenuated the level of plasma lipid profiles along with an increase in HDL. Additionally, level of myocardial antioxidants significantly increased along with a reduction in the content of malondialdehyde. The cardioprotective effect was compared with propranolol     (10 mg/kg, oral) which was used as the standard. Histopathological findings revealed a decrease in the degree of necrosis and inflammation following pretreatment with <em>Polygonum glabrum</em>. Conclusion: The present investigation indicates that <em>Polygonum glabrum</em> could protect myocardium from isoproterenol induced necrosis.</p>

scholarly journals Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fatiqa Zafar ◽  
Nazish Jahan ◽  
Khalil-Ur-Rahman ◽  
Ahrar Khan ◽  
Waseem Akram
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Histopathological Examination ◽  
Cardiac Injury ◽  
Myocardial Necrosis ◽  
Myocardial Cell ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Synthetic Drugs ◽  
Plant Mixture

The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plantsT. arjuna(T.A.),P. nigrum(P.N),C. grandiflorus(C), andC. oxyacantha(Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

scholarly journals EVALUATION OF ANTI-HYPERTROPHIC POTENTIAL OF CAMELLIA SINENSIS IN ISOPROTERENOL INDUCED CARDIAC HYPERTROPHY

2018 ◽  
Vol 10 (10) ◽  
pp. 119
Author(s):  
Doss V. A. ◽  
Jeevitha Parthibhan ◽  
Dharaniyambigai Kuberapandian
Keyword(s):  
Lactate Dehydrogenase ◽  
Cardiac Hypertrophy ◽  
Aqueous Extract ◽  
Marker Enzymes ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Cardiac Marker ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

Objective: Camellia sinensis (C. sinensis family-Theaceae) has potent antioxidant activity used in the treatment of cardiovascular disease. The present study evaluates the cardioprotective (anti-hypertrophic) effect of aqueous extract of C. sinensis in isoproterenol (ISO) induced cardiac hypertrophic rats.Methods: The beneficial effect of the green tea extract was examined by the administration of the aqueous extract of the leaves of C. sinensis (100 mg/kg b.w., oral., 7 d) in ISO (10 mg/kg b.w., subcutaneous.,7 d) induced cardiac hypertrophic rats with reference to the standard drug, losartan (50 mg/kg b.w., oral.,7 d) followed by biochemical estimations of glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) in serum and heart tissues thus collected at the end of 7 d.Results: The biochemical assays revealed significantly (P<0.05) increased glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) lactate dehydrogenase (LDH) and significantly (P<0.05) decreased in ISO induced cardiac hypertrophic rats that were reciprocated by the effect of plant extract.Conclusion: Thus, this study showed that the aqueous leaf extract of C. sinensis possesses potent effect against cardiac hypertrophy. This potential is hypothesized to be due to the phytochemical, Catechin present in the plant that requires further isolation and characterization with respect to anti-hypertrophic therapeutics.

scholarly journals ANTI-OBESITY EFFECTS OF THE METHANOL EXTRACT OF MOMORDICA FOETIDA (CUCURBITACEAE) IN MALE WISTAR RATS

2021 ◽  
pp. 31-35
Author(s):  
CHOUMESSI T. APHRODITE ◽  
CHI H. A. NKWENTI ◽  
SOH DESIRE ◽  
MBOUH MARIAM ◽  
ATSAMO A. DONATIEN
Keyword(s):  
Methanol Extract ◽  
Risk Index ◽  
Normal Diet ◽  
Low Density Lipoproteins ◽  
The Body ◽  
Atherogenic Index ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Reference Drug

Objective: This study was designed to evaluate the effect of the methanol extract of M. foetida (MEMf) on high fat diet-induced obese male rats. Results: HFD induced an increase (P<0.05) in the body and liver weights and the relative abdominal fat pad of the animals in the experimental groups as compared to those in the normal diet group. Also, HFD in the experimental groups reduced (P<0.05) superoxide dismutase and catalase activities, glutathione levels and increased lipid peroxidation in the liver, heart and kidney as well as altered lipid profile (increased serum triglycerides, total cholesterol, low-density lipoproteins (LDL-C), very low-density lipoproteins (VLDL-C), decreased high-density lipoproteins (HDL-C), increased atherogenic index and coronary risk index), when compared to the normal diet animals. All altered parameters were subsequently normalized when obese rats received either MEMf (50 or100 mg/kg) or the reference drug Atorvastatin. Conclusion: This study demonstrates the potential of MEMf to normalize hyperlipidemia, oxidative stress and animal visceral organ weights increased by HFD in rats. Thus, M. foetida is an interesting medicinal plant that could be exploited as sources of anti-obesity agents.

scholarly journals Cardioprotective Effect of Ethanolic Flower Extract of ClitoriaTernatea on Doxorubicin Induced Cardiotoxicity in Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1604-1611
Author(s):  
Tamizhselvi A ◽  
Durairaj S ◽  
Mohamed Sadiq A ◽  
Gopinath G ◽  
Rajeshkumar S
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Heart Tissue ◽  
Marker Enzyme ◽  
Aspartate Transaminase ◽  
Marker Enzymes ◽  
Serum Enzyme ◽  
Cardiac Marker ◽  
Flower Extract

There was a significant evidence that there are several of the medicinal plants encompass the prospective to treat cardiovascular disease. In this study, Doxorubicin is used as an effectual induction of cardiotoxicity and heart malfunction in the taken experimental rats which is an anthracycline chemotherapeutic mediator used to the treat of a wide variety of malignancies. To examine the shielding property of ethanolic flower extract of clitoraternatea  (EECT) scheduled doxorubicin(DOX) persuaded cardiotoxicity via albino wistar rats,through inspect the enzymatic,non-enzymatic antioxidant position,serum enzyme and Histopathology tissue.Experimental rats been provoked cardiotoxicity by means of a generous single dose of doxorubicin (15mg /body weight ) and treated orally through an ethanolic extract of clitoraternatea (EECT)  for 14 days (100 mg/kg bw, 200 mg/kg bw and 300mg/kg bw,n=5).On15 days, the rats are sacrificed by treated through Ketamine –Xylazine,Biochemical as well as histological remarks of the heart tissues had carry out. Cardiotoxicity had been calculated throughout to establish the cardio marker enzyme levels such as (LDH) Lactic acid dehydrogenase,(CK-MB) Creatinin kinase and (AST) Aspartate transaminase at the finish of the study. Managementthrough EECT of 200mg/kg and 300mg/kgconsiderablyreduced the levels of cardiac marker enzymes(p<0.05), and as wellminimize the decrease of weight of the heart of DOX treated group. In heart tissue superoxide dismutase, glutathione and catalase heightsbe significantly greater than before and lipid oxide peroxide (LPO) significantly decreased in the extract (200 &300 mg /kg bw) treated rats when compared to DOX treated with the significance of  P< 0.05. There was no significant recovery of the 100 mg/kg of EECT. These results will suggested that EECT having potential anti-cardiotoxic effects induced by Doxorubicin by preventing oxidative injure provoke by DOX in heart of taken experimental animals.

Superoxide anion-induced peroxidation of human low density lipoproteins (LDL). Influence of the pH

1993 ◽  
Vol 90 ◽  
pp. 917-930
Author(s):  
D Bonnefont-Rousselot ◽  
M Gardès-Albert ◽  
S Lepage ◽  
J Delattre ◽  
C Ferradini
Keyword(s):  
Superoxide Anion ◽  
Low Density Lipoproteins ◽  
Low Density

Nonenzymatic glycosylation of low density lipoproteins in vitro. Effects on cell-interactive properties

Diabetes ◽  
1981 ◽  
Vol 30 (10) ◽  
pp. 875-878 ◽  
Author(s):  
B. Gonen ◽  
J. Baenziger ◽  
G. Schonfeld ◽  
D. Jacobson ◽  
P. Farrar
Keyword(s):  
Low Density Lipoproteins ◽  
Low Density ◽  
Nonenzymatic Glycosylation ◽  
In Vitro Effects
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