scholarly journals Tumor de células de la granulosa juvenil de ovario. Presentación inusual. Reporte de un caso

2021 ◽  
Vol 81 (01) ◽  
pp. 92-97
Author(s):  
Ernesto Lara ◽  
◽  
Franco Calderaro ◽  
Carmen Silva ◽  
Johatson Freytez
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Adult Type ◽  
Palpable Mass ◽  
Juvenile Granulosa Cell Tumor ◽  
Juvenile Type ◽  
Precocious Pseudopuberty ◽  
Ovary Tumor ◽  
Immunohistochemical Studies

Granulose cell tumors represent 2% of ovarian tumors. They are classified as adult type and juvenile type. The juvenile type is associated with precocious pseudopuberty, irregular menstruation or nonspecific symptoms such as abdominal pain and palpable mass. More than 95% are confined to the ovary. A case of a 31-year-old patient is described. The patient consulted for 6-month evolution of increased abdominal volume and weight loss. Right ovary tumor was diagnosed. Tumor excision by gynecological laparotomy with positive frozen cut biopsy and surgical staging were performed. Pathological anatomy reported stromal tumor, and sexual cords suggestive of malignant juvenile granulose cell tumor. Immunohistochemistry reported positive inhibin B. It was concluded as stage IIIA2. This is a rare neoplasm with variable behavior. Accurate diagnosis is based on histological and immunohistochemical studies. Key words: Granulosa, Cell tumor, Juvenile granulosa cell tumor, Ascites, Diagnosis.

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males

2012 ◽  
Vol 136 (7) ◽  
pp. 825-828 ◽  
Author(s):  
Joema F. Lima ◽  
Long Jin ◽  
Ana Rose C. de Araujo ◽  
Michele R. Erikson-Johnson ◽  
Andre M. Oliveira ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Leydig Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Adult Type ◽  
Male Adult ◽  
Granulosa Cell Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Leydig Cell Tumors

Context.—Granulosa cell tumors comprise less than 5% of ovarian tumors in women and are much rarer in men, with only about 20 cases reported, to our knowledge. Recently, a somatic mutation of FOXL2 was reported in virtually all adult-type granulosa cell tumors in women. Objective.—To investigate FOXL2 mutations in granulosa cell tumors occurring in males. Design.—Five cases of an adult-type granulosa cell tumor from males were selected from the files of the Mayo Clinic. Nine other testicular tumors (1 juvenile granulosa cell tumor, 5 Leydig cell tumors, and 3 Sertoli-Leydig cell tumors) were evaluated for comparison. Inhibin immunostain was performed in all cases. DNA was extracted from formalin-fixed, paraffin-embedded tissue, followed by polymerase chain reaction and direct sequencing of FOXL2. Results.—All 5 cases had classic histopathologic features of the adult-type granulosa cell tumor. Inhibin was diffusely positive in all cases. FOXL2 402C→G (C134W) was identified in 40% (2 of 5) of the male, adult-type granulosa cell tumors. Of the 2 tumors positive for the mutation, 1 occurred in the testis of a man, and the other one affected the abdominal ovaries of a phenotypically male patient. All other testicular tumors were negative for the mutation. Conclusions.—The FOXL2 402C→G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with the rates reported in women. FOXL2 mutational analysis can be a helpful in the diagnosis of granulosa cell tumors of the testis.

scholarly journals Extraovarian Granulosa Cell Tumor of Mesentery: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Manjiri R. Naniwadekar ◽  
N. J. Patil
Keyword(s):  
Granulosa Cell ◽  
Histopathological Examination ◽  
Previous History ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Genital Ridge ◽  
Adult Type ◽  
Mesenteric Mass ◽  
History Of ◽  
Ovary Tumor

Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. A 54 years old female patient presented with a mass and acute pain in abdomen. Exploratory laparatomy revealed hemoperitoneum with a large mesenteric mass measuring 13 × 12 cm in size, showing extensive areas of haemorrhages. Histopathological examination of the excised mass showed features of adult-type GCT. As the patient had a history of hysterectomy with bilateral salpingo-oophorectomy 10 years ago for ‘‘leiomyoma’’ with no evidence of GCT of the ovary in the histopathology report, a diagnosis of extraovarian GCT was made. A diagnosis of extraovarian GCT should be carried out after excluding any previous history of GCT of the ovary. Tumor rupture with haemoperitoneum is a well-known complication of GCT. Extraovarian GCT is a rare tumor with only 10 cases reported in literature. The case is presented for its rarity.

scholarly journals Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Dimosthenis Miliaras ◽  
Eleftherios Anagnostou ◽  
Ioannis Moysides
Keyword(s):  
Granulosa Cell ◽  
Smooth Muscle Actin ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Placental Alkaline Phosphatase ◽  
Alpha Smooth Muscle Actin ◽  
Adult Type ◽  
Left Testis ◽  
Juvenile Type ◽  
Potentially Malignant

Granulosa cell tumor (GST) is a sex-cord/stromal neoplasm of the gonads, more commonly arising in the ovaries, while approximately 80 cases have been reported in the testes. Out of these, 30 cases were of the adult type, while the remainder 50 cases were of the juvenile type. The latter mostly concerned infants and followed a benign course. However, the adult type testicular GCTs may be potentially malignant as it also happens in female patients with such neoplasms. We present a case of an adult type GCT located at the left testis. The patient was subjected to total orchiectomy and received no further treatment. Histology showed typical GCT histomorphology with Call-Exner bodies in some places. The immunoprofile of the tumor was CD99 (+), calretinin (+), inhibin (+), alpha smooth muscle actin (+), vimentin (+), ER (−), PR (−), keratin AE1/AE3 (−), alpha fetoprotein (−), CD117 (−), and placental alkaline phosphatase (−). Two years after surgery, the patient is alive and well with no signs of recurrence.

Cystic adult-type granulosa cell tumor in a 7-year-old girl with precocious pseudopuberty

2012 ◽  
Vol 54 (3) ◽  
pp. 426-428
Author(s):  
Maria Korpal-Szczyrska ◽  
Joanna Stefanowicz ◽  
Ewa Iżycka-Świeszewska ◽  
Danuta Sierota ◽  
Marta Kozłowska ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Adult Type ◽  
Precocious Pseudopuberty

A rare case of ovarian juvenile granulosa cell tumor without precocious pseudopuberty in an 11-month-old infant

2012 ◽  
Vol 47 (1) ◽  
pp. 269-270 ◽  
Author(s):  
Mohamed Moncef Hamdane ◽  
Rym Dhouib ◽  
Lamia Charfi ◽  
Raoudha Doghri ◽  
Karima Mrad ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Rare Case ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Juvenile Granulosa Cell Tumor ◽  
Precocious Pseudopuberty

Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases.

1988 ◽  
Vol 6 (6) ◽  
pp. 990-995 ◽  
Author(s):  
G Vassal ◽  
F Flamant ◽  
J M Caillaud ◽  
F Demeocq ◽  
C Nihoul-Fekete ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Recurrent Disease ◽  
Stage Iv ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Pediatric Department ◽  
One Stage ◽  
Juvenile Granulosa Cell Tumor ◽  
Precocious Pseudopuberty

Juvenile granulosa cell tumor (JGCT) in children accounted for 12% of all ovarian tumors treated in the Institut Gustave-Roussy (IGR) Pediatric Department from 1967 to 1985. The median age of the 15 girls was 8 years 7 months (range, 22 months to 15 years 7 months). Precocious pseudopuberty was present in six of the seven girls under 8 years. Of the other seven girls, one developed virilization symptoms. Surgery was the first treatment in each case. According to the Wollner classification, there were six stage I, one stage II, six stage III (including four ruptured tumors), and one stage IV JGCT cases. One patient was not available for staging. An adjuvant treatment (five chemotherapy and one radiotherapy combined with chemotherapy) was administered to six patients. Eleven girls are alive and free of disease, with a median follow-up of 6 years (range, 2 to 18 years). Four girls relapsed 6 to 17 months after surgery and died. Two of these relapses occurred in bone. The prognosis for JGCT in children is favorable for the lower stages when treated with surgery, but the best treatment for extensive and recurrent disease has yet to be determined.

scholarly journals Juvenile granulosa cell tumor

2016 ◽  
Author(s):  
Geetanjali Tuteja ◽  
S. Unmesh ◽  
S. Shree ◽  
S. Rudra ◽  
Keyword(s):  
Granulosa Cell ◽  
Precocious Puberty ◽  
Early Stage ◽  
Pubertal Development ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Tumour Resection ◽  
Granulosa Cell Tumour ◽  
Juvenile Granulosa Cell Tumor

The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumour of the ovary–and a brief literature review. A one year-old baby girl presented with mass abdomen, vaginal discharge and rapid onset of pubertal development. She underwent an exploratory laparotomy for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

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