scholarly journals Sildenafil: efectos en la calidad espermática del hombre subfértil

2021 ◽  
Vol 81 (01) ◽  
pp. 13-21
Author(s):  
Elinor Moreno ◽  
◽  
Nellys Fonseca ◽  
Sheyla Rodríguez
Keyword(s):  
Informed Consent ◽  
Therapeutic Option ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Sperm Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Progressive Motility ◽  
Prior Informed Consent ◽  
Before And After

Objective: To evaluate the effect of sildenafil on the sperm parameters of subfertile men who attended the fertility service of the Maternidad Concepción Palacios, between June 2011 and December 2013. Methods: A clinical, prospective, descriptive, experimental, cross-sectional study was conducted, prior informed consent, in 28 subfertile men with diagnosed asthenozoospermia, by performing two basal spermogram. Thereafter, they were given 50 mg of sildenafil, one hour before obtaining the sample, for a third and final spermogram. Results: Among the 28 patients studied, it was shown an increased progressive motility post-treatment in 21 patients (75%) which was statistically significant (p-0.000); the volume ejaculated before and after treatment had no statistically significant differences (p-0.405), as well as sperm concentration (p-1,000). Conclusions: The use of sildenafil in patients with diagnosed asthenozoospermia represents an economical therapeutic option, easy to acquire, and comply with in the treatment of this pathology. Keywords: Asthenozoospermia, Sildenafil, Semen.

scholarly journals Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
W. N. Li ◽  
M. M. Jia ◽  
Y. Q. Peng ◽  
R. Ding ◽  
L. Q. Fan ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Sectional Study ◽  
Joinpoint Regression ◽  
Cross Sectional ◽  
Progressive Motility ◽  
Infertile Men

Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.

scholarly journals Sperm parameters and anti-Müllerian hormone remain stable with Helicobacter pylori infection: a cross-sectional study

BMC Urology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Chun Feng ◽  
Ping-Ping Lv ◽  
Chang-Chang Huang ◽  
Song-Qing Yang ◽  
Qiu-Ping Yao ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Ovarian Reserve ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Sperm Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Sperm Analysis ◽  
Significant Difference ◽  
Subgroup Analyses

Abstract Background and aims It has been reported that Helicobacter pylori (HP) infection was more prevalent in infertile populations. HP infection could lead to decreased sperm parameters, and treating the HP infection could improve the quality of sperm. However, studies investigating the relationship between infertility and HP infection are still limited, and more evidence is required. Therefore, we performed the present study to investigate the impact of HP infection on sperm quality in males and on ovarian reserve in females. Methods A total of 16,522 patients who visited the Second Hospital of Zhejiang University from January 2016 to June 2019 due to abdominal discomfort and underwent a 13/14C-urea breath HP test were included in this retrospective cross-sectional study. Among them, 565 had performed sperm analysis or ovarian reserve tests in the past three months and were involved for further analyses. Sperm parameters were examined with a computer-assisted sperm analysis system, and serum anti-Müllerian hormone (AMH) and sex hormones were tested with an electrochemiluminescence method. Results Among 363 patients who underwent the sperm test, 136 (37.47%) had HP infection. Among 202 patients who underwent the AMH test, 55 (27.23%) had HP infection. There was no difference in sperm concentration and motility between the HP+ and HP− groups (P > 0.05). Further subgroup analyses stratified into 5-year age groups confirmed that there was no significant difference in sperm parameters (P > 0.05). When pooled with previously published data, no significant difference in sperm concentration or motility was found (P > 0.05). Meanwhile, this study found that the serum AMH level was similar between the HP+ and HP− groups (P > 0.05). Further subgroup analyses confirmed that there was no significant difference in serum AMH level (P > 0.05). Conclusions There were no differences in sperm parameters and AMH levels based on history of HP infection among Chinese patients.

scholarly journals GAMBARAN TEKANAN DARAH PADA PEMAIN MUSIK DI SEKOLAH MUSIK TOMS YAMAHA MUSIC SCHOOL MANADO

2013 ◽  
Vol 1 (3) ◽  
Author(s):  
Hermin Garusim ◽  
Joice N. A Engka ◽  
Siantan Supit
Keyword(s):  
Blood Pressure ◽  
Informed Consent ◽  
Mild Hypertension ◽  
Musical Instrument ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Music School ◽  
Before And After ◽  
Music Player

Abstract: Blood pressureand pulse rateis very important in the health sectorin general, and particularly in the field of medicine, since the blood pressure and pulse rateis a factor that can be used as an indicator to assessa person's cardiovascular system. Blood pressure is the force used by the blood against the walls of blood vessels (arteries). Blood pressure is a vital sign in the human body. Numerous studies have shown an relationship between changes of blood pressure with pounding music that are to heard or playing a musical instrument. Physiologically increases and decreasesin blood pressurecan becaused bya particulargenre. As well as the increase and decrease in blood pressure both before and after playing music in fluenced by physical activity while playing certain musical instruments. For example, a drum player, his blood pressure willincrease two-fold in time afterplayingthe music, and theviolin decreased time after playing music. The purpose of this study, was to determine what kind of instrument music that can increase and decrease blood pressure. The type of research is observational with cross sectional study. The variable in this study is a music player and high blood pressure. The subjects was students in the school musical TOM's Yamaha Music School as many as 40 people who have met the criteria for inclusion are aged 10-35 years consisted of men and women, physically and mentally healthy, not suffering from hypertension and signed the informed consent. Measurement of blood pressure used tensimeter aneroid ABN spectrum and Littmann stethoscope. Before playing the music, the averages blood pressure with result that optimal is 106/74mmHg, the averages blood pressure with result that normal is 121/80mmHg, the averages blood pressure with result that high normal is 130/90mmHg, and the averages blood pressure with result that mild hypertension is 140/92mmHg. Based on this research, it was found there are difference in a blood pressure before and after playing music. The normal blood pressure before playing music and will increase or decrease in time after playing the music.Key words: Blood pressure, MusicAbstrak: Tekanan darah dan denyut nadi merupakan hal yang sangat penting dalam bidang kesehatan pada umumnya dan khususnya di bidang Kedokteran, karena tekanan darah maupun denyut nadi merupakan faktor yang dapat dipakai sebagai indikator untuk menilai sistem kardiovaskuler seseorang. Tekanan darah adalah tenaga yang di gunakan oleh darah terhadap diding pembuluh darah (arteri). Tekanan darah merupakan salah satu tanda vital di dalam tubuh manusia. Sejumlah penelitian menunjukkan adanya keterkaitan antara perubahan tekanan darah dengan dentuman musik baik yang hanya didengarkan maupun pada saat memainkan alat musik. Secara fisiologis peningkatan dan penurunan tekanan darah dapat diakibatkan oleh aliran musik tertentu. Serta Peningkatan dan penurunan tekanan darah pada saat sebelum dan sesudah bermain musik dipengaruhi oleh aktifitas fisik saat memainkan alat musik tertentu. Misalnya pemain musik drum, tekanan darahnya akan meningkat dua kali lipat pada saat sesudah bermain musik, dan violin (biola) menurun saat sesudah bermain musik.Tujuan dari penelitian ini adalah untuk mengetahui jenis alat musik apa yang dapat meningkatkan dan menurunkan tekanan darah. Adapun jenis penelitian ini adalah observasional dengan rancangan cross sectional study. Adapun variable pada penelitian ini adalah pemain musik dan tekanan darah. Subjek penelitian ini adalah siswa – siswi di sekolah musik TOM’s Yamaha Music school yaitu sebanyak 40 orang yang telah memenuhi criteria inklusi yaitu berumur 10-35 tahun terdiri atas pria dan wanita, sehat jasmani dan rohani, tidak menderita hipertensi dan menandatangani informed consent. Pengukuran tekanan darah menggunakan tensimeter aneroid ABN spectrum dan stetoskop Littman. Sebelum bermain musik hasil didapatkan tekanan darah optimal dengan rata – rata tekanan darah 106/74mmHg, tekanan darah normal dengan rata – rata 121/80mmHg, tekanan darah normal tinggi 130/90mmHg, dan tekanan darah dengan hipertensi ringan rata – rata 140/92mmHg. Berdasarkan penelitian yang telah dilakukan, didapatkan adanya perbedaan tekanan darah yang dilakukan saat sebelum dan sesudah bermain musik. Tekanan darah normal pada saat sebelum bermain musik dan akan meningkat atau menurun pada saat sesudah bermain musik.Kata Kunci : tekanan darah, musik

scholarly journals Association of the Dietary Approaches to Stop Hypertension, Physical Activity, and Their Combination with Semen Quality: A Cross-Sectional Study

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 39
Author(s):  
Anna Danielewicz ◽  
Jakub Morze ◽  
Mariusz Przybyłowicz ◽  
Katarzyna Eufemia Przybyłowicz
Keyword(s):  
Physical Activity ◽  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dash Diet ◽  
Progressive Motility

The influence of individual lifestyle factors is widely described in studies on semen quality. However, their synergistic effect is often neglected. The aim of the study was to examine the association between semen quality and dietary approaches to stop hypertension (DASH) diet, physical activity (PA), and the two separately and in combination. A cross-sectional study was carried out among 207 men aged 20–55. Dietary data were collected by a food frequency questionnaire (FFQ) and analysed according to the DASH scoring index. Physical activity was evaluated by the International Physical Activity Questionnaire. Semen parameters were assessed via the computer-aided semen analysis (CASA). Adherence to the DASH diet was associated with higher sperm count (ΔT3-T1 = 82.1 mln/ej) and concentration (ΔT3-T1 = 24.6 mln/mL). Higher PA was related to higher sperm count (ΔT3-T1 = 69.4 mln/ej), total (ΔT3-T1 = 11.9%), and progressive motility (ΔT3-T1 = 8.5%) and morphology (ΔT3-T1 = 2.8%) in the crude model and remained significant after adjustment. The combination of the DASH diet and PA, was significantly positively associated with sperm count (ΔT3-T1 = 98.1 mln/ej), sperm concentration (ΔT3-T1 = 17.5 mln/mL), total (ΔT3-T1 = 11.8%), and progressive motility (ΔT3-T1 = 10.0%) and morphology (ΔT3-T1 = 3.3%) in both models. Adherence to the DASH diet was related to higher sperm count and concentration, whereas after its combination with physical activity it was also positively correlated with sperm motility and morphology.

scholarly journals 732. Evaulation of Micafungin Treatment at Pediatric Patients: A cross-sectional Study from Tertiary Pediatric Centre

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S416-S417
Author(s):  
Kamile Arıkan ◽  
Nuri Bayram ◽  
İlker devrim ◽  
Ayküke Akaslan-Kara
Keyword(s):  
Amphotericin B ◽  
Liver Function Tests ◽  
Cross Sectional Study ◽  
Resistance Rate ◽  
Sectional Study ◽  
Candida Spp ◽  
Cross Sectional ◽  
Median Serum ◽  
Before And After ◽  
Resistance Patterns

Abstract Background Micafungin is one of three currently available echinocandin for treatment of candidiasis and candidemia. Methods Children who were treated for micafungin for possible or proven invasive Candidia infection between May 2017 and October 2019 were included. Results In this cross-sectional study, totally 78 children with a median age of 3 months (8 days -17 years), 50 (64.1%, F/M: 0.56) male were included. Thirty four (43.6%) patients were neonate, 26 (76 %) of them were premature. Thirty seven patients (47.4%) received micafungin for candidemia and 41 (52.6%) patients received micafungin empirically for IC. Twelve (32.4%) Candida spp cultured were C. albicans, the rest twenty five (67.6%) Candida spp were non-albicans Candida spp. The most commonly cultured Candida spp was Candida parapsilosis (C. parapsilosis) (n=13) followed by C. albicans (n=12), C. glabrata (n=3), C. tropicalis (n=3), C. guilliermondii (n=3), C. krusei (n=2) respectively. Resistance rate of C. parapsilosis (n=13) isolates to fluconazole, voriconazole, amphotericin B, caspofungin, micafungin were as follows respectively; 66.7%, 100%, 69.2%, 90.9%, 37.5% respectively. Resistance rate of C. albicans (n=11) isolates to fluconazole, voriconazole, amphotericin B, caspofungin, micafungin were as follows respectively; 50%, 50%, 12.5%, 42.9%, 0% respectively. None of the C. tropicalis, C. guilliermondii and C. krusei isolates were resistant to micafungin. Culture negativity could not be achieved at the end of 14th day of micafungin treatment in the 15 (16.9%) candidemia episodes. The most commonly isolated Candida spp in patients with treatment failure was C. parapsilosis (n=7), the other species were; C. albicans (n=5), C. guilliermondii (n=1), C. tropicalis (n=1) and C. tropicalis and C. guilliermondii coinfection (n=1) respectively. Median serum AST, ALT and creatinin levels didn’t increase during and at the end of micafungin therapy. None of these patients had experienced an anormal kidney or liver function tests due to micafungin usage. Characteristics of patients who received micafungin.and cultured Candida spp Antifungal resistance patterns of Candida spp. Laboratory change before and after micafungin treatment Conclusion Increase in fluconazole resistant Candida spp makes micafungin a reasonable and effective choice for suspected or proven invasive candidiasis Disclosures All Authors: No reported disclosures

scholarly journals Obstetric Violence in Spain (Part III): Healthcare Professionals, Times and Areas

2021 ◽  
Vol 18 (7) ◽  
pp. 3359
Author(s):  
Desirée Mena-Tudela ◽  
Susana Iglesias-Casás ◽  
Víctor Manuel González-Chordá ◽  
María Jesús Valero-Chillerón ◽  
Laura Andreu-Pejó ◽  
...  
Keyword(s):  
Public Health ◽  
Primary Care ◽  
Informed Consent ◽  
Healthcare Professionals ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lack Of Information ◽  
Obstetric Violence

Background: Obstetric violence is a worldwide public health problem, which seems greater in Spain. As no studies were found that identify the most representative healthcare professionals, times, and areas involved in obstetric violence, the objective of this work was to study at what time of maternity, with which professionals, and in what areas women identified obstetric violence. Methods: This descriptive, retrospective, and cross-sectional study was performed from January 2018 to June 2019. The main variables were the area (hospital, primary care, both), the time (pregnancy, birth, puerperium), and the professionals attending to women. Results: Our sample comprised 17,541 participants. The area identified with the most obstetric violence for the different studied variables was hospitals. Women identified more obstetric violence at time of birth. Findings such as lack of information and informed consent (74.2%), and criticism of infantile behavior and treatment (87.6%), stood out. The main identified healthcare professionals were midwives and gynecologists, and “other” professionals repeatedly appeared. Conclusions: Having identified the professionals, times, and areas of most obstetric violence in Spain, it seems necessary to reflect on not only the Spanish National Health System’s structure and management but also on healthcare professionals’ training.

scholarly journals The Impact of Bariatric Surgery on Menstrual Abnormalities—a Cross-Sectional Study

2020 ◽  
Vol 30 (11) ◽  
pp. 4505-4509
Author(s):  
Anna Różańska-Walędziak ◽  
Paweł Bartnik ◽  
Joanna Kacperczyk-Bartnik ◽  
Krzysztof Czajkowski ◽  
Maciej Walędziak
Keyword(s):  
Bariatric Surgery ◽  
Menstrual Cycle ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Obese Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Contraception Use ◽  
Before And After ◽  
The Impact

Abstract Introduction Obesity is associated with hyperestrogenism along with other hormonal abnormalities affecting the menstrual cycle. The most effective and decisive method of obesity treatment is bariatric surgery. The aim of this study was to analyze the impact of bariatric surgery on menstrual cycle, the incidence of menstrual abnormalities, hyperandrogenism manifestation, and contraception use. Materials and Methods It was a cross-sectional study of 515 pre-menopausal women who had undergone bariatric surgery between 1999 and 2017 in a bariatric center. Data was collected via anonymous questionnaire, and the questions covered a 1-year period before the surgery and the last year before questionnaire completion. Results Before the surgery, 38.6% of the patients reported irregular menstruations in comparison with 25.0% after bariatric surgery (RR = 0.65; 95%CI 0.53–0.79). The mean number of menstruations per year did not differ before and after surgery (10.2 ± 3.9 vs 10.4 ± 3.3; p < .45). There were no statistically significant differences in terms of prolonged menstruations, acne, and hirsutism prevalence. A total of 14.4% of patients before surgery reported estrogen-based contraception use in comparison with 15.0% after the surgery (p < .95). There were no significant differences in the frequency of OC use (11.0% before surgery vs 13.6% 12 months after the surgery vs 11.5% at the moment of survey administration; p < 0.46). Conclusion Bariatric surgery improves the regularity of the menstrual cycle in obese women in reproductive age. The lack of any changes in the combined hormonal contraception (CHC) use, especially OC, before and after bariatric surgery may be a result of a possibly low level of contraception counseling.

scholarly journals Malondialdehyde Levels in Preeclampsia before and after Delivery

1970 ◽  
pp. 143
Author(s):  
Harold Rumopa ◽  
Freddy W. Wagey ◽  
Eddy Suparman
Keyword(s):  
Oxidative Stress ◽  
Plasma Levels ◽  
Cross Sectional Study ◽  
Hplc Method ◽  
Wilcoxon Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Average Value ◽  
Significant Difference ◽  
Before And After

  Objective: Determine differences plasma levels MDA in preeclampsiabefore and 2 hours after delivery.   Methods: This was an analytic cross-sectional study. Subjectconsists of 23 pregnancies with preeclampsia, where 23 bloodsamples taken before delivery and 23 were taken 2 hours afterdelivery. This study was conducted from August 2016 untilDecember 2016 at Department of Obstetrics and GynecologyFaculty of Medicine Universitas Sam Ratulangi / Prof. Dr. R. D.Kandou Hospital Manado and satellite hospital. Samples weretaken from plasma and analysed using HPLC method at Prodiaclinical laboratory.   Results: In patients with severe preeclampsia before deliverywe found average value (1.4796  0.40819 nmol/ml), minimumvalue (1.03 nmol/ml) and maximal value (2.77 nmol/ml)and 2 hours after delivery with average value (1.2470 0.34324 nmol/ml), minimum value (0.91 nmol/ml), and maximumvalue (2.47 nmol/ml). by using Wilcoxon test, we foundthere were significant differences in plasma levels of MDA (p =0.000).   Conclusion: This significant difference suggests that decreasedplasma levels of MDA 2 hours after delivery and gives the sense thatthere is a relationship between oxidative stress of cells with severepreeclampsia before and shortly after delivery, that MDA is an indicatorof oxidative stress.   Keywords: malondialdehyde, oxidative stress, peroxidation lipid,preeclampsia

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