scholarly journals Efficacy of Autologous Platelet Rich Plasma in the Treatment of Male Androgenetic Alopecia

Esculapio ◽  
2021 ◽  
Vol 16 (4 (oct 2020 - dec 2020)) ◽  
Author(s):  
Nadia Naeem ◽  
Saadiya Siddiqui ◽  
Atif Shehzad ◽  
Kehkshan Tahir ◽  
Marrium Manzoor
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Data Entry ◽  
Stage Iv ◽  
Androgenetic Alopecia ◽  
Case Series Study ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Male Patients ◽  
Autologous Platelet

Objective: To assess the outcome of autologous platelet rich plasma(PRP) for the treatment of androgenetic alopecia in male patients. Methods: A total of 61 male patients from Department of Dermatology, Lahore General Hospital Lahore with ages between 18-60 years were included in the study during a period of 6 months. PRP was prepared by double spin method and CaCl2 was used to activate platelets. PRP was injected, with a 30-G needle using Nappage technique. This descriptive case series study was carefully monitored. Protocol included three treatment sessions with an interval of four weeks. Number of hairs, and hair strength was assessed by dermoscopy and hair pull test. SPSS Version-21 was used for data entry and analysis. Results: The mean age of patients was 42.67±8.63 years. Mean number of hair was 21.50±4.57 per dermatoscopic field, Post treatment number of hair was 78.10±16.24. Mean duration of disease was 10.25±3.52 months. Majority of patients were in stage iv 19(31.1%) and in stage ii 16(26.2%). There was significant difference in number of hair before and after treatment. Conclusion: PRP is an effective method to treat the patients with androgen alopecia. Key Words: Autologus platelet rich plasma, Androgen alopecia. How to Cite: Naeem N, Siddiqui S, Shehzad A, Tahir K, Manzoor M. Efficacy of autologous platelet rich plasma in the treatment of male androgenetic alopecia. Esculapio.2020;16(04):41-45.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

scholarly journals Successful Management of Treatment-Resistant Alopecia Areata with Platelet Rich Plasma: A Case Series

2019 ◽  
Vol 11 (2) ◽  
pp. 50-52
Author(s):  
Sanjeewani Fonseka ◽  
Y.M.D.M Bandara ◽  
Brabaharan Subhani
Keyword(s):  
Alopecia Areata ◽  
Platelet Rich Plasma ◽  
Case Reports ◽  
Immunosuppressive Agents ◽  
Case Series ◽  
Treatment Resistant ◽  
Successful Management ◽  
Autologous Platelet Rich Plasma ◽  
Dermal Injection ◽  
Autologous Platelet

Abstract Introduction. Alopecia areata (AA) is an autoimmune disease-causing non-scarring alopecia. It is usually treated with immunosuppressive agents, to which some patients fail to respond adequately. Material and Methods. Three patients with AA refractory to standard therapy were treated with intra-dermal injection of autologous platelet rich plasma (PRP) every four weeks. Results. All three patients showed remarkable improvement after multiple sessions of PRP treatment. Conclusion. Autologous PRP is safe and effective in treatment-resistant forms of AA demonstrated in many case reports; therefore it deserves further study with randomized, placebo-controlled trials.

scholarly journals Comparison of Allogeneic Platelet-rich Plasma With Autologous Platelet-rich Plasma for the Treatment of Diabetic Lower Extremity Ulcers

2020 ◽  
Vol 29 ◽  
pp. 096368972093142
Author(s):  
Min He ◽  
Xuewen Guo ◽  
Tao Li ◽  
Xiaoyan Jiang ◽  
Yan Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lower Extremity ◽  
Adverse Reactions ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Ankle Brachial Index ◽  
Nutritional Regulation ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Autologous platelet-rich plasma (au-PRP) has been widely used for the management of refractory chronic wounds. However, patients with diabetic lower extremity ulcers (DLEUs) usually have complicated clinical conditions, and the utility of au-PRP is limited. In this study, the feasibility, effectiveness, and safety of allogeneic platelet-rich plasma (al-PRP) and au-PRP were investigated and compared in the treatment of DLEUs. A total of 75 in-patients with type 2 diabetes were assigned to the al-PRP group ( n = 20), au-PRP group ( n = 25), and conventional wound therapeutic (CWT) group ( n = 30) matched by the ankle brachial index and ulcer size from December 2015 to August 2018. Based on metabolic and nutritional regulation, infective control, and topical wound management, al-PRP, au-PRP, and CWT were administered to each group, respectively. Evaluation of treatment outcomes was determined by the parameters of wound healing and adverse reactions. The therapeutic times and average concentration of platelets were not significantly different between the au-PRP and al-PRP groups. The wound healing times of the al-PRP group (56.9 ± 29.22 d) and au-PRP group (55.6 ± 33.8 d) were significantly shorter than those of the CWT group (88.0 ± 43.4 d) ( P < 0.01), but there was no significant difference between the groups with PRP treatment. Although there was no significant difference in the daily healing area among all groups ( P > 0.05), the trend of the healing rate in the al-PRP group (16.77 ± 12.85 mm2), au-PRP group (14.31 ± 18.28 mm2), and CWT group (9.90 ± 8.51 mm2) gradually decreased. No obvious adverse reactions (fever, edema, pain, skin itching, rash, or other sensory abnormalities) were observed in either the au-PRP or the al-PRP groups. Both al-PRP and au-PRP could effectively and safely promote wound healing in patients with DLEUs. Alternatively, al-PRP could be used for DLEUs as an off-the-shelf solution when au-PRP is limited. Registration number of clinical trials: ChiCTR1900021317

Development of Hyperalgesia in Patients Treated with Autologous Platelet Rich Plasma Due to Androgenetic Alopecia

2018 ◽  
Vol 3 (34) ◽  
pp. 90-93
Author(s):  
Mehmet Emin Cem Yildirim ◽  
Bilsev Ince ◽  
Orkun Uyanik ◽  
Mehmet Ihsan Okur ◽  
Mehmet Dadaci
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Bisphosphonate-Related Osteonecrosis of the Jaws–An Initial Case Series Report of Treatment Combining Partial Bone Resection and Autologous Platelet-Rich Plasma

2011 ◽  
Vol 69 (9) ◽  
pp. 2465-2472 ◽  
Author(s):  
Marcos Martins Curi ◽  
Giuliano Saraceni Issa Cossolin ◽  
Daniel Henrique Koga ◽  
Cristina Zardetto ◽  
Silmara Christianini ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Bone Resection ◽  
Osteonecrosis Of The Jaws ◽  
Case Series Report ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Series Report

The haemostatic effectiveness of autologous platelet rich plasma sequestered after heparin administration and institution of cardiopulmonary bypass

Perfusion ◽  
1995 ◽  
Vol 10 (2) ◽  
pp. 101-110 ◽  
Author(s):  
RL Quigley ◽  
JA Perkins ◽  
JA Caprini ◽  
El Haney ◽  
SS Switzer ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Blood Loss ◽  
Platelet Rich Plasma ◽  
Homologous Blood ◽  
Homologous Blood Transfusion ◽  
Heparin Administration ◽  
Significant Difference ◽  
Autologous Platelet Rich Plasma ◽  
Induced Aggregation ◽  
Autologous Platelet

Preoperative harvesting and postoperative reinfusion of autologous platelet rich plasma (PRP) has been reported to decrease blood loss as well as the requirement for homologous blood transfusion following cardiopulmonary bypass (CPB). We have developed a technique of intraoperative PRP sequestration which occurs during the initial period of CPB after the patient's circulation is supported and heparin has been given (PRP+). This process does not require any additional hardware, personnel or expense and it is performed without difficulty or complication. To evaluate the effect of PRP+ sequestration and reinfusion on blood loss and homologous blood requirement after CPB, we randomly assigned 126 consecutive patients undergoing elective open heart surgery into the experimental group 1 (PRP+) (n = 64) or the control (no platelet pheresis) group 2 (n = 52). A third group (n = 10) were not included in the randomization. Patients in group 3 had PRP prepared by conventional techniques (PRPc) prior to heparin administration and given to the patient after protamine infusion. Aggregation and activation studies were performed on the PRP+, PRPc, and blood bank platelets (BBP). Per cent aggregation of PRP in response to ADP was superior to that of BBP. There were no significant differences in ADP induced aggregation between PRP+ and PRPc. There was no significant difference in platelet activation (CD62) or number between the three groups. Patients infused with PRP+ showed significantly increased aggregation to ADP when compared with untreated patients 120 minutes after return to the ICW. Furthermore, more homologous haemostatic components (platelets/fresh frozen plasma) were required in the control group. We have demonstrated that collection of autologous PRP+ after administration of heparin does not interfere with its haemostatic effectiveness compared with PRPc prepared before the initiation of bypass. Moreover, this can be performed universally in haemodynamically unstable patients without any additional costs.

scholarly journals The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series

2012 ◽  
Vol 01 (03) ◽  
pp. 29-32 ◽  
Author(s):  
Natsuko Kakudo ◽  
Satoshi Kushida ◽  
Tsunetaka Ogura ◽  
Tomoya Hara ◽  
Kenji Suzuki ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Case Series ◽  
Skin Ulcer ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet
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