scholarly journals Pharmacognostical and Antimalarial Studies of Tamarindus indica Leaves

2021 ◽  
Vol 23 (06) ◽  
pp. 1601-1607
Author(s):  
Dr. Md. Rageeb Md. Usman ◽  
◽  
Badgujar Pallavi Sunil ◽  
Keyword(s):  
Plasmodium Falciparum ◽  
Plasmodium Vivax ◽  
Tartaric Acid ◽  
Antimalarial Activity ◽  
Dimethyl Sulphoxide ◽  
Diffusion Method ◽  
Tamarindus Indica ◽  
Zone Of Inhibition ◽  
Antimicrobial Test ◽  
Living Organisms

The present study was performing to know the Antimalarial activity of Tamarind (Tamarindus indica L.) The plant T. indices were collected further by using methanol the extract residue diluted 10% Dimethyl sulphoxide extract from which were produced. The plate diffusion method was used as an antimicrobial test for Plasmodium falciparum and Plasmodium vivax by a zone of inhibition tested.TLC standardization ensures the presence of tartaric acid in the extracted sample against the standard. leaves possess near to standard Antimalarial activity which was confirmed by its effect on experimental living organisms.

scholarly journals Enhanced Antibacterial activity of Capparis decidua fruit mediated Selenium Nanoparticle against Enterococcus faecalis

2021 ◽  
Vol 12 (1) ◽  
pp. 6-11
Author(s):  
Anushya P ◽  
Preetha S ◽  
Lavanya Prathap ◽  
Jeevitha M
Keyword(s):  
Antibacterial Activity ◽  
Enterococcus Faecalis ◽  
Opportunistic Pathogen ◽  
Diffusion Method ◽  
Zone Of Inhibition ◽  
Human Needs ◽  
Selenium Nanoparticle ◽  
Uv Visible ◽  
Capparis Decidua ◽  
Living Organisms

Nanotechnology has become one among the promising approaches for innovations which fulfil the human needs. Nanoparticles even have many applications in several fields like nanocomposites, medical imaging, nanobiocomposite filters, targeted drug delivery and hyperthermia of tumours. In which Selenium is an important micronutrient for living organisms. These nanoparticles are safe, eco friendly, inexpensive and nontoxic. Enterococcus faecalis  is an emergent gram - positive opportunistic pathogen that is the causative agent of several nosocomial infections and surgical wound infections. Therefore, it is becoming increasingly necessary to find other alternative treatments than commonly utilized drugs. The purpose of this study is to assess the antibacterial activity of Capparis decidua  fruit mediated selenium nanoparticles( cds-se Nps ) against Enterococcus faecalis. In this experimental study Se Nps were prepared by the reaction of 30mM sodium selenite solution and extracts of Capparis decidua. Antibacterial activity of SeNPs was assessed by using a disc diffusion method against Enterococcus faecalis. The SeNPs were characterized by UV-visible spectrophotometers. In the present study, the zone of inhibition shows 32mm, 35 mm, 37mm and 30 mm at concentration of 50 microliter, 100 microliter, 150 microliter and antibody respectively. The Capparis decidua  fruit mediated SeNp showed a good antibacterial activity against the pathogen Enterococcus faecalis 

scholarly journals In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine

1998 ◽  
Vol 42 (3) ◽  
pp. 540-544 ◽  
Author(s):  
O. Domarle ◽  
G. Blampain ◽  
H. Agnaniet ◽  
T. Nzadiyabi ◽  
J. Lebibi ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Tartaric Acid ◽  
Antimalarial Activity ◽  
Chloroquine Resistance ◽  
Highly Effective ◽  
Human Therapy ◽  
Potential Use

ABSTRACT The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adaptedPlasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.

scholarly journals Antibacterial and cytotoxic activity of Tamarindus indica (Tamarind) seeds

2019 ◽  
Vol 27 ◽  
pp. 83-88
Author(s):  
MM Hasan ◽  
SA Rahman ◽  
MS Akhter
Keyword(s):  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Cytotoxic Activity ◽  
Inhibitory Concentration ◽  
Methanol Extract ◽  
Ethanol Extract ◽  
Diffusion Method ◽  
Tamarindus Indica ◽  
Zone Of Inhibition ◽  
Seed Extracts

The crude ethanol and methanol extracts of Tamarindus indica seeds have been investigated to evaluate their antibacterial and cytotoxic potentialities. Extracts were screened for their antibacterial activity against both gram positive and negative bacteria primarily by disc diffusion method and then minimum inhibitory concentration (MIC) assay. Besides the cytotoxic activity were screened by using brine shrimp lethality bioassay. The average zone of inhibition for ethanol extract of seeds of tamarind was ranged from 7.5 - 13.5 mm for 500 μg/disc. And for methanol extract the zone of inhibition was ranged from 6.5 - 13.25 mm for 500 μg/disc. From MIC assay minimum inhibitory concentration was found 1.25 mg/ml for ethanol and 0.625 mg/ml for methanol extract. The minimum bactericidal concentration was found 2.5 mg/ml for ethanol and 1.25 mg/ml for methanol extract. Compared to vincristine sulfate (with LC50 of 0.99 μg/ml) both ethanol and methanol extract of T. indica seeds showed toxicity lower than 100 μg/ml and greater than 30 μg/ml. The study confirms greater antibacterial activity of T. indica seed extracts with moderate cytotoxic activity. This study thus demands isolation of active principles and thorough bioassays. J. bio-sci. 27: 83-88, 2019

scholarly journals Stage-dependent effect of deferoxamine on growth of Plasmodium falciparum in vitro

Blood ◽  
1990 ◽  
Vol 76 (6) ◽  
pp. 1250-1255 ◽  
Author(s):  
S Whitehead ◽  
TE Peto
Keyword(s):  
Plasmodium Falciparum ◽  
Growth Inhibition ◽  
Antimalarial Activity ◽  
Clinical Malaria ◽  
Inhibitory Effect ◽  
Parasite Development ◽  
And Control ◽  
Speed Of Onset

Abstract Deferoxamine (DF) has antimalarial activity that can be demonstrated in vitro and in vivo. This study is designed to examine the speed of onset and stage dependency of growth inhibition by DF and to determine whether its antimalarial activity is cytostatic or cytocidal. Growth inhibition was assessed by suppression of hypoxanthine incorporation and differences in morphologic appearance between treated and control parasites. Using synchronized in vitro cultures of Plasmodium falciparum, growth inhibition by DF was detected within a single parasite cycle. Ring and nonpigmented trophozoite stages were sensitive to the inhibitory effect of DF but cytostatic antimalarial activity was suggested by evidence of parasite recovery in later cycles. However, profound growth inhibition, with no evidence of subsequent recovery, occurred when pigmented trophozoites and early schizonts were exposed to DF. At this stage in parasite development, the activity of DF was cytocidal and furthermore, the critical period of exposure may be as short as 6 hours. These observations suggest that iron chelators may have a role in the treatment of clinical malaria.

scholarly journals In vitro activities of novel catecholate siderophores against Plasmodium falciparum.

1996 ◽  
Vol 40 (9) ◽  
pp. 2094-2098 ◽  
Author(s):  
B Pradines ◽  
F Ramiandrasoa ◽  
L K Basco ◽  
L Bricard ◽  
G Kunesch ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Mechanism Of Action ◽  
Ribonucleotide Reductase ◽  
Antimalarial Activity ◽  
Iron Chelators ◽  
Resistant Clone ◽  
Iron Deprivation ◽  
Level Of Activity ◽  
Susceptible Clone

The activities of novel iron chelators, alone and in combination with chloroquine, quinine, or artemether, were evaluated in vitro against susceptible and resistant clones of Plasmodium falciparum with a semimicroassay system. N4-nonyl,N1,N8-bis(2,3-dihydroxybenzoyl) spermidine hydrobromide (compound 7) demonstrated the highest level of activity: 170 nM against a chloroquine-susceptible clone and 1 microM against a chloroquine-resistant clone (50% inhibitory concentrations). Compounds 6, 8, and 10 showed antimalarial activity with 50% inhibitory concentrations of about 1 microM. Compound 7 had no effect on the activities of chloroquine, quinine, and artemether against either clone, and compound 8 did not enhance the schizontocidal action of either chloroquine or quinine against the chloroquine-resistant clone. The incubation of compound 7 with FeCI3 suppressed or decreased the in vitro antimalarial activity of compound 7, while no effect was observed with incubation of compound 7 with CuSO4 and ZnSO4. These results suggest that iron deprivation may be the main mechanism of action of compound 7 against the malarial parasites. Chelator compounds 7 and 8 primarily affected trophozoite stages, probably by influencing the activity of ribonucleotide reductase, and thus inhibiting DNA synthesis.

Sign in / Sign up

Export Citation Format

Share Document