scholarly journals COVID-19 and Standardized Vaccines Development: A Brief Review

2021 ◽  
Vol 23 (05) ◽  
pp. 325-343
Author(s):  
Nisha Kaushik ◽  
◽  
Arti R. Thakkar ◽  
K. Bangarurajan ◽  
◽  
...  

The severe acute respiratory syndrome coronavirus disease (COVID-19) pandemic brings a global emergency affecting all civilizations. After the initial spread from Wuhan City atypical form of pneumonia to other areas of the world led the world health organization to look after it as a pandemic situation. The clinical coronavirus now spread all over the globe and brutally affected almost all countries including community transmission. The current capital of coronavirus cases in the US, trailed by India and Brazil, respectively. The most common symptoms were mild to moderate respiratory discomfort. Lung was the main targeting organ for COVID-19 infection resulting in severe pneumonia. Furthermore, severe acute respiratory distress syndrome (ARDS), acute cardiac injury, along with pathological features such as RNAaemia with shared ground-glass opacities that may be a cause for death in patients. The surface glycoproteins may be responsible for this garnishing of the virus belonging to the Coronaviridae family. Vaccines work to enhance the immune system of the body by training and making it ready to fight a specific pathogenic agent. At present there over 50 COVID-19 vaccine candidates are in trials, some of which are now ready to deliver via emergency use authorization (EUA). The vast majority of viral vaccines currently licensed for humans can be categorized as inactivated or live-attenuated viruses and protein-based subunit vaccines. Hence, we hereby review the significance of certain genotypic vaccines that are currently subjected for development such as non-replicating viral vectors, mRNA vaccine, self-amplifying mRNA vaccine, DNA vaccine, whole-virus inactivated vaccine, and a subunit vaccine. The current review also explores the mode of pathogenesis and invasion of COVID-19 virus to host cell that would be well-comprised data for future studies in the concerned area of interest.

Author(s):  
Daniele Melo Sardinha ◽  
Karla Valéria Batista Lima ◽  
Thalyta Mariany Rêgo Lopes Ueno ◽  
Yan Correa Rodrigues ◽  
Juliana Conceição Dias Garcez ◽  
...  

Cardiovascular Diseases represent the main cause of death in the world, and are associated with risk factors that cause serious complications in cases of infections, such as those of the respiratory tract. In March 2020 the World Health Organization declared a pandemic for SARS-CoV-2, a new coronavirus causing severe pneumonia, which emerged in December 2019 in Wuhan, China. The objective is to investigate the occurrence of cardiovascular complications associated with SARS-CoV-2 infection. It is a systematic review, quantitative, in the databases, PubMed and Science direct, including primary studies with hospitalized patients confirmed for COVID-19 and who presented cardiovascular complications, the form used tools for evaluation of quality and evidence, following the PRISMA recommendations. Results: 12 studies were included. The occurrence of cardiovascular complications was: 27.35% of the sample of 3,316 patients. Types: Acute cardiac injury 17.09%; Thromboembolism 4.73%; Heart failure 3.43%; Arrhythmias 1.77%; stroke 0.33%. Mean age 61 years. Conclusions: This study showed that there are several cardiovascular complications associated with SARS-CoV-2, that the main one is acute cardiac injury, which causes several instabilities in the cardiopulmonary system, and that it is associated with mortality.


2020 ◽  
Author(s):  
Daniele Melo Sardinha ◽  
Karla VB Lima ◽  
Thalyta MRL Ueno ◽  
Yan Correa Rodrigues ◽  
Juliana CD Garcez ◽  
...  

AbstractCardiovascular Diseases represent the main cause of death in the world, and are associated with risk factors that cause serious complications in cases of infections, such as those of the respiratory tract. In March 2020 the World Health Organization declared a pandemic for SARS-CoV-2, a new coronavirus causing severe pneumonia, which emerged in December 2019 in Wuhan, China. The objective is to investigate the occurrence of cardiovascular complications associated with SARS-CoV-2 infection. It is a systematic review, quantitative, in the databases, PubMed and Science direct, including primary studies with hospitalized patients confirmed for COVID-19 and who presented cardiovascular complications, the form used tools for evaluation of quality and evidence, following the PRISMA recommendations. Results: 12 studies were included. The occurrence of cardiovascular complications was: 27.35% of the sample of 3,316 patients. Types: Acute cardiac injury 17.09%; Thromboembolism 4.73%; Heart failure 3.43%; Arrhythmias 1.77%; stroke 0.33%. Mean age 61 years. Conclusions: This study showed that there are several cardiovascular complications associated with SARS-CoV-2, that the main one is acute cardiac injury, which causes several instabilities in the cardiopulmonary system, and that it is associated with mortality.


Leprosy ◽  
2020 ◽  
pp. 1-19
Author(s):  
Charlotte A. Roberts

This chapter introduces leprosy, an infection that is still misunderstood and considered a neglected tropical disease but declining in frequency, according to the World Health Organization. The bacteria that cause leprosy, Mycobacterium leprae and Mycobacterium lepromatosis, are outlined, as well as how a relative strength of a person’s immune system determines how leprosy affects the body. Although leprosy is curable, associated stigma and disability remain common challenges for people with the disease in parts of the world. The goals and structure of the book are outlined, ten myths that still pervade society at large are listed, and the use of the word “leper” discussed. Based on World Health Organization data, the chapter also explores the frequency of leprosy today, where the infection remains a challenge, and the history of detecting and reporting evidence for leprosy in living populations. Finally, the reasons why bioarchaeologists have an interest in this infection are explored.


2019 ◽  
Vol 6 (1) ◽  
pp. 14-20
Author(s):  
Betti Rosita ◽  
Helvina Mustika

Based on the results of a survey conducted by the World Health Organization (WHO) in 2012, the number of active smokers in the world has reached more than 1 billion people. This number is expected to continue to increase given the high prevalence of world cigarette consumption rates, while in Indonesia it is found that almost every year the number of smokers is increasing. Cigarettes containing chemicals including carbon monoxide, nicotine, tar, ammonia, arsenic, cyanide and lead (Pb) The main effect is lead that is inhaled and enters the respiratory system will also circulate throughout the tissues and organs of the body. More than 90% of lead metal absorbed by blood binds to red blood cells and results in a disruption in the process of hemoglobin synthesis. The purpose of this study is to determine the level of lead metal toxicity with an overview of smear preparations in the blood of active smokers. The research method with simple random sampling, samples taken capillary blood and making blood smear preparations that were examined with a microscope while examining the metal in the urine using Atomic Absorption Spectrophotometer (AAS). The results of the study of lead content in urine of active smokers found that the high is 0.384 mg / dl and the low lead level is 0.002 mg / dl positive containing lead in the urine with the amount of lead content exceeding the threshold and from the results of the smear dosage found that normal or normociter cell size can be obtained normal or normochrome (1/3 of the center is pale) whereas abnormalities in the cell form are teardrop cells, ovalocytes, schistocyte, this is due to the effect of lead that disrupts health especially usually occurs in haemotopoetic systems (blood formation system)


2021 ◽  
Vol 11 (3) ◽  
pp. 1-2

Every year on 24 March, World Tuberculosis Day is commemorated annually, for raising the public awareness regarding devastating consequences of tuberculosison health and economic aspects of life. This helps to launch efforts to end the globalepidemic of tuberculosis. On the date of 24th March in 1882, Dr. Robert Koch announced about the discovery of bacterium that causes tuberculosis.1 It was held on 24th March 1982 first time by The World Health Organization at the 100th anniversary of Dr. Koch’s discovery. The target 3.3 of SDG calls for, by 2030, ending the epidemics of tuberculosis, malaria, AIDS, combat other communicable and water-borne diseases. A large number of people 1.7 billion, roughly 23% of the world's population suffered from tuberculosis. In the world, each year 1.5 million people died due to TB, proving it a leading infectious killer disease. Thirty countries having the high burden of TB, accounted for 87% of new TB cases during 2019.2 Among these, two thirds of the total cases were in India, Indonesia, China, Bangladesh, Philippines, Pakistan, Nigeria, and South Africa. An estimated 510,000 new TB cases are emerging each year in Pakistan. Among these about, 15 000 are developing drug resistant TB cases. Pakistan is bearing 61% of the TB burden in the EMRO. Tuberculosis is preventable and curable disease. The causative agent of tuberculosis, Mycobacterium tuberculosis, most often affect the lungs. The vaccine for tuberculosis (TB) disease is called BCG (Bacille Calmette-Guérin). In 1921, first patient was vaccinated with BCG vaccine, 13 years were spent in the making the vaccine. In countries where TB is common, BCG vaccine is given to infants and small children. It does not always protect people from getting TB. BCG vaccine is included in national Expanded Program on Immunization (EPI) in Pakistan and given at birth. To make TB free Pakistan through universal access to quality TB care, National TB Control Program (NTP) is striving for achieving Zero TB death by reducing 50% prevalence of TB in general population by 2025. The mode of transmission of TB from person to person is through the air. The TB germs are propelled into the air,when people with lung TB cough, sneeze or spit carelessly due to lack of awareness that they are participating in the spread of disease and weakening the efforts. These germs are when inhaled by other people, resulting in lung infection, which is called primary TB. From primary TB infection, majority of people recover withoutany further evidence of the disease. For years the infection may stay inactive (latent). People with TB infection are not contagious, do not have any symptoms, and do not put their friends, co-workers and family at risk. Many people who have latent TB infection never develop TB disease. In these people, the TB bacteria remain inactive for a lifetime without causing disease. But in other people, especially people who have weak immune systems, the bacteria become active, multiply, and cause TB disease. There is good news for people with TB disease! It can almost always be treated and cured with medicine. But the medicine must be taken as directed by Physician. The relapse rate differs by a country's incidence and control: 0–27% of TB relapses occur within 2 years after treatment completion and most relapses occur within 5 years; however, some relapses occur 15 years after treatment. A person who has genital tuberculosis can infect others through sexual contact. The most common means of spreading genital TB can be through blood or lymph. Hence, sexual contact can spread genital tuberculosis. Genital tuberculosis can spread to any other body organ, once it enters the body. Consuming a diet high in nutritious foods and beverages is a smart way to support and protect lung health. Coffee, dark leafy greens, fatty fish, peppers, tomatoes, olive oil, oysters, blueberries, and pumpkin are just some examples of foods and drinks that have been shown to benefit lung function. Milk can be used by TB patient. It is also a great source of protein, providing strength necessary to perform day-to-day activities. Directly observed treatment, short-course (DOTS, also known as TB-DOTS) is the name given to the tuberculosis (TB) control strategy recommended by the World Health Organization. According to WHO, "The most cost-effective way to stop the spread of TB in communities with a high incidence is by curing it. The usual treatment is: two antibiotics (isoniazid and rifampicin) for 6 months, two additional antibiotics (pyrazinamide and ethambutol) for the first 2 months of the 6-month treatment period. Groups with high rates of TB transmission are homeless persons, injection drug users, and persons with HIV infection are more susceptible for TB and persons who have immigrated from areas of the world with high rates of TB. The disease is prevalent mainly in the underprivileged sections of the society. The lack of knowledge in the masses and the communities is a factor that contributes largely to the spread of the disease. The theme of World TB Day 2020 was “It's TIME to end TB” and in 2021 it is,” Am I stopping TB” highlighting the importance of awareness. It is the time to fuel the awareness program with full energy, resources and ways. In such a scenario, there is always a need for new and innovative ideas to create mass awareness about tuberculosis. The more focus of this awareness campaign should be very much targeted towards people living in an area where there are a lot of people are with TB, or have been homeless or live in poorly ventilated or overcrowded housing and sufferers of a weakened immune system.


2020 ◽  
Vol 02 (03) ◽  
pp. 21-24
Author(s):  
Gulara Rufat Sadikhova ◽  
◽  
Sayali Yolchu gizi Ibrahimova ◽  

It is common knowledge that the Diabetes is a widespread disease of the endocrine system. To outline the main points, it is worth too say that Diabetes is a chronic disease associated with an absolute or relative deficiency of the hormone insulin, wherein the insulin secreted by the pancreas and cleaves the glucose in the blood. Diabetes affects many organ systems of the body so that the most severe complication of the disease is coma. Therefore, in the treatment of the disease, sugar-reducing drugs and mandatory diet are used. It comes as no surprise that almost 422 mln of the world's population suffer from Diabetes, as it is stipulates by the World Health Organization statistics. Key words: Diabetes, hormone insulin, diet, coma


2014 ◽  
Vol 7 (1) ◽  
pp. 531 ◽  
Author(s):  
Karim Eldin M Salih ◽  
Jalal A Bilal ◽  
Mona A Alfadeel ◽  
Yassin Hamid ◽  
Widad Eldouch ◽  
...  

2021 ◽  
Vol 3 (2) ◽  
pp. 178
Author(s):  
Dwi Kartika Pebrianti ◽  
Armina Armina

The case of the Corona Virus is known through a mysterious disease that paralyzed the City of Wuhan, China. The tragedy at the end of 2019 has continued until the spread of the Corona virus has spread throughout the world. Quoted from CNN, here are some things that must be known about the development of the Corona virus, which is commonly called the Corona virus or COVID-19, until it broke out and became a pandemic. Everyone needs to maintain mental health to avoid physical complaints that arise due to stress. Because when someone is stressed, the immune system in the body will decrease. This will cause the body to be susceptible to disease. Realizing that anxiety due to COVID-19 has pervaded many communities, the World Health Organization (WHO) in March 2020 released a guide for people to jointly maintain mental health. Through community service activities by directly interacting with the community while still implementing the COVID-19 protocol, socialization was carried out about the importance of maintaining mental health in the community during the Covid-19 Pandemic. Community service at RT 30 Recognize Besar, the community can know, recognize and overcome how to recognize mental health disorders including anxiety and depression, it is hoped that the community will always think optimistically in facing the Covid-19 pandemic, by implementing health protocols, maintaining a healthy lifestyle, regular exercise, always think positively, maintain communication with family and friends


2021 ◽  
Vol 32 ◽  
pp. 04002
Author(s):  
Alexey Yevglevsky ◽  
Andrey Gostev

One of the global, vital problems of humanity is iodine deficiency. According to the World Health Organization (WHO), more than 2 billion people live in conditions of iodine deficiency. people: among them, 740 million have endemic goiter, 43 million have mental retardation, more than 6 million. they suffer from cretinism (an extreme degree of mental retardation). Currently, iodine deficiency diseases are the most common non-infectious diseases in the world. What about mammalian animals? In animals, iodine performs the same functions as in humans. Animals, especially agricultural animals, are just as sensitive to iodine deficiency as humans. With a lack of iodine in the body of animals, the biosynthesis of thyroid hormones is disrupted, which leads to a decrease in the intensity of redox processes, as a result of which all types of metabolism are disrupted:-protein, fat, carbohydrate, macro – and microelement, energy. In this regard, the failure of the thyroid gland is accompanied by the development of severe pathobiochemical processes, which, in the end, leads to the clinical manifestation of pathophysiological conditions. Taking into account the fact that in conditions of constant iodine deficiency it is very problematic to ensure the health of productive animals, the issues of prevention of iodine deficiency conditions are economically significant for industrial animal husbandry. It is no accident that in countries experiencing natural iodine deficiency, state programs have been developed that provide for the use of iodine-containing additives in the diets of productive animals. Despite the fact that the simplest and most affordable method of eliminating iodine deficiency in humans and animals is the inclusion of iodized salt in the diet, however, this method can not be used for veterinary purposes. First of all, the feed method of using biologically active additives eliminates the possibility of dosed therapeutic or preventive treatment. On the pages of this article, we draw attention to the emerging prospects for the use of a new iodine-metabolic composition in non-infectious and infectious pathology, based on an iodine polymer complex known in pharmacology as iodinol and succinic acid.


Author(s):  
Shreerag Devkumar ◽  
Rakesh Kumar Jha ◽  
Dhruba Hari Chandi

Corona viruses (CoVs) are well-covered RNA viruses that cause enteric and respiratory infections in humans and animals. Many human CoVs have recently gained global interest because of their lethal power and high contagious power. SARS-CoV-2, or COVID-19, is a pathogenic coV that first appeared in Wuhan, China. Corona virus Disease 2019 (COVID-19) created by SARS-CoV-2, has been declared as pandemic by the World Health Organization since March 11, 2020. The epidemic started in Wuhan and spread rapidly around the world. Corona virus is facing a major epidemic: Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). SARS-CoV-2 is a virus closely related to SARS. Corona virus (COVID-19) is caused by SARS-CoV-2 VIRUS, a complex clinical disorder characterized by severe pneumonia and acute respiratory stress syndrome. Serious and neurological disorders, such as encephalitis, coma, fever, epilepsy, and Guillain-Barré syndrome, are more common in cases of COVID-19. In addition, chronic autoimmune and neurodegenerative diseases may occur in SARS-CoV-2 immunopathology and colonization of intestinal and central nervous system, as well as systemic inflammatory response during COVID-19. Parkinson's disease is a common neurodegenerative condition that causes the development of motor and non-motor symptoms.


Sign in / Sign up

Export Citation Format

Share Document