scholarly journals Computational Virtual Screening of Sulfonylurea chalcones as New Class of 5-Lipoxygenase Inhibitors by Molecular Docking Studies

2013 ◽  
Vol 78 (13) ◽  
pp. 44-47
Author(s):  
Bharat KumarBugata ◽  
S V G K Kaladhar Dowluru ◽  
Vasudeva Rao Avupati
Keyword(s):  
Molecular Docking ◽  
Virtual Screening ◽  
Docking Studies ◽  
Lipoxygenase Inhibitors ◽  
Molecular Docking Studies ◽  
New Class

scholarly journals A new class of potential antidiabetic acetohydrazides: Synthesis, in vivo antidiabetic activity and molecular docking studies

2017 ◽  
Vol 12 (3) ◽  
pp. 319 ◽  
Author(s):  
Mubeen Arif ◽  
Furukh Jabeen ◽  
Aamer Saeed ◽  
Irfan Zia Qureshi ◽  
Nadia Mushtaq
Keyword(s):  
Molecular Docking ◽  
Video Clip ◽  
Docking Studies ◽  
Antidiabetic Activity ◽  
Molecular Docking Studies ◽  
H Nmr ◽  
New Class ◽  
Full Screen ◽  
Pharmacologically Active

<p class="Abstract">Two new pharmacologically active series of tetrazolopyridine-acetohydrazide conjugates [9 (a-n), 10 (a-n)] were synthesized by reacting a variety of suitably substituted benzaldehydes and isomeric 2-(5-(pyridin-3/4-yl)-2H-tetrazol-2-yl)acetohydrazides (7, 8). The synthesized compounds were analyzed through FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and elemental techniques. These acetohydrazides were screened for their in vivo antidiabetic activity and molecular docking studies. An excellent agreement was obtained as the best docked poses show-ed important binding features mostly based on interactions due to an oxygen atom and aromatic moieties of the series. The compounds 9a, 9c and 10l were found to be the most active in lowering blood glucose, having the potential of being good antidiabetic agents.</p><p><strong>Video Clip of Methodology</strong>:</p><p>Synthesis of 3/4-(2H-tetrazole-5-yl)pyridine: 1 min 57 sec   <a href="https://www.youtube.com/v/CHp8HxlEa2M">Full Screen</a>   <a href="https://www.youtube.com/watch?v=CHp8HxlEa2M">Alternate</a></p>

Diazaspiro-iminosugars and polyhydroxylated spiro-bislactams: synthesis, glycosidase inhibition and molecular docking studies

RSC Advances ◽  
2015 ◽  
Vol 5 (65) ◽  
pp. 52907-52915 ◽  
Author(s):  
Vijay Singh Parihar ◽  
Nitin J. Pawar ◽  
Sougata Ghosh ◽  
Balu Chopade ◽  
Navanath Kumbhar ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
New Class ◽  
Glycosidase Inhibition

Synthesis of a new class of iminosugars 1–4 has been reported.

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