scholarly journals Changes in the levels of comet parameters before and after fluoxetine therapy in major depression patients

2020 ◽  
Vol 53 (2) ◽  
pp. 194-200
Author(s):  
Rajeev Panwar ◽  
M. Sivakumar ◽  
Vikas Menon ◽  
Balasubramaniyan Vairappan
Keyword(s):  
Major Depression ◽  
Before And After ◽  
Fluoxetine Therapy

scholarly journals Electroconvulsive Therapy and Age: Effectiveness, Safety and Tolerability in the Treatment of Major Depression among Patients under and over 65 Years of Age

2021 ◽  
Vol 14 (6) ◽  
pp. 582
Author(s):  
Monika Dominiak ◽  
Anna Z. Antosik-Wójcińska ◽  
Marcin Wojnar ◽  
Paweł Mierzejewski
Keyword(s):  
Major Depression ◽  
Autobiographical Memory ◽  
Electroconvulsive Therapy ◽  
Cognitive Functions ◽  
Rating Scale ◽  
Short Form ◽  
Serious Adverse Events ◽  
Before And After ◽  
Trail Making ◽  
Resistant Depression

Electroconvulsive therapy (ECT) remains the most effective therapy in treatment-resistant depression. However, the safety of ECT has been consistently questioned, particularly among elderly patients. We assessed the efficacy and safety of ECT in patients before and after 65 years old. The study was conducted between 2015 and 2018 and included 91 patients (61 under and 29 over 65 years old) with major depression undergoing ECT. The Hamilton Depression Rating Scale was used to evaluate efficacy. Cognitive functions were assessed using: MMSE, RAVLT, Trail Making Test, Stroop Test and Autobiographical Memory Interview-Short Form. ECT was more effective in older patients as compared to younger (p < 0.001). No serious adverse events were observed in either group. Increased blood pressure and arrhythmias were more common in the older compared to the younger group (p = 0.044 and p = 0.047, respectively), while disturbances of consciousness did not differ between groups (p = 0.820). Most of the cognitive functions remained unchanged compared to baseline, whereas the outcomes of MMSE, RAVLT and Stroop tests showed greater improvements in the older compared to the younger group (all p < 0.05). The decline in the retrieval consistency of autobiographical memory was more pronounced in the younger group (p = 0.024). ECT is a highly effective, safe and well-tolerated method of treating depression regardless of age.

Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in major depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 904-904
Author(s):  
F.D. Garcia ◽  
Q. Coquerel ◽  
E. Kiive ◽  
P. Déchelotte ◽  
J. Harro ◽  
...  
Keyword(s):  
Major Depression ◽  
Physical Exercise ◽  
Plasma Levels ◽  
Plasma Cortisol ◽  
Cortisol Response ◽  
Cortisol Secretion ◽  
Mild Depression ◽  
Moderate Depression ◽  
Before And After ◽  
Underlying Mechanisms

IntroductionAbnormal vasopressin (VP) and oxytocin (OT) signaling may contribute to the altered activity of the hypothalamo-pituitary-adrenal (HPA) axis in major depression; the underlying mechanisms remain uncertain.ObjectiveThis study characterized plasma levels and affinities of OT-and VP-reactive autoantibodies (autoAbs) with relation to disease severity and plasma cortisol response to physical exercise in patients with mild and moderate depression and healthy controls.MethodsPhysical exercise was used to elicit plasma cortisol response in 23 male depressive and 20 healthy subjects. All subjects were evaluated by the MADRS. Plasma levels VP-and OT-reactive IgG, IgA and IgM autoAbs were measured by ELISA, before and after the exercise, and affinity was measured by plasmon resonance.ResultsPlasma levels of OT-and VP-reactive total IgG autoAbs were lower in patients with moderate depression vs. controls and patients with mild depression. Both OT- and VP- free IgG autoAbs levels were negatively correlated with MADRS scores. Affinity values displayed 100 fold variability in both groups. Patients with moderate depression displayed blunted response of cortisol secretion to physical exercise. Baseline levels of VP total IgG and IgM autoAbs correlated negatively and of VP free IgG autoAbs correlated positively with plasma cortisol after physical exercise.ConclusionThese data show that changes of levels but not affinity of OT- and VP- reactive autoantibodies can be associated with the altered mood in subjects with moderate depression and that levels of VP-reactive autoAbs are associated with cortisol secretion.

Memory, Attention, and Executive Functions Before and After Sine and Pulse Wave Electroconvulsive Therapies for Treatment-Resistant Major Depression

2006 ◽  
Vol 22 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Akiko Fujita ◽  
Shutaro Nakaaki ◽  
Kazuhisa Segawa ◽  
Hideki Azuma ◽  
Kiyoe Sato ◽  
...  
Keyword(s):  
Major Depression ◽  
Executive Functions ◽  
Pulse Wave ◽  
Treatment Resistant ◽  
Before And After

scholarly journals The Effect of Dignity Therapy on Hope in Patients with Major Depression Disorder

2016 ◽  
Vol 8 (12) ◽  
pp. 118 ◽  
Author(s):  
Saeed Vaghee ◽  
Abbas Heydari
Keyword(s):  
Clinical Trial ◽  
Major Depression ◽  
Therapy Group ◽  
T Test ◽  
Control Group ◽  
Major Depression Disorder ◽  
Dignity Therapy ◽  
Therapy Effect ◽  
Before And After ◽  
Depression Disorder

<p><strong>INTRODUCTION:</strong> Despite the importance of the hope level increment in the patients with major depression disorder, fewer interventions have been applied to improve the hope level in the psychiatric patients, especially the depressed individuals.</p><p><strong>OBJECTIVE:</strong> To identify the dignity therapy effect on the hope level in the patients with major depression disorder.</p><p><strong>METHOD:</strong> In this random controlled clinical trial, 58 patients with major depression disorder, who were hospitalized in Ibn-e-Sina psychiatric hospital of Mashhad, were separated into two intervention (28 individuals) and control (30 individuals) groups. The intervention group has taken the dignity therapy (based on the standard protocol in three 30-45 minutes sessions) and the control group have been undertaken the normal caregiving without intervention. The research tool was the Herth hope index, which was filled exactly before and after intervention. The data analysis has been done by SPSS 11.5 and exact Fischer tests, Chi square, independent t-test and paired t-test.</p><p><strong>RESULTS:</strong> 65.5 percent of the patients were female and 34.5 percent were male. Before the intervention, there was no significant statistical difference between the dignity therapy group (19.9±2.8) and the control group (20.5±1.6) in the average total hope score (p=0.39). However, the variations of the average total hope score before and after intervention between the dignity therapy group (4.7±2.9) and the control group (0.1±1.9) was significant (p&lt;0.001).</p><p><strong>CONCLUSIONS:</strong> According to the dignity therapy effect on the hope level increment in patients with major depression disorder, this unique and short clinical trial can be employed to increase the hope level in the patients with depression disorder.</p>

Enhanced Serotonergic Responsivity Following Electroconvulsive Therapy in Patients with Major Depression

1992 ◽  
Vol 160 (2) ◽  
pp. 223-229 ◽  
Author(s):  
Baruch Shapira ◽  
Bernard Lerer ◽  
Seth Kindler ◽  
Pesach Lichtenberg ◽  
Cornelius Gropp ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Major Depression ◽  
Depressive Disorder ◽  
Plasma Prolactin ◽  
Major Depressive ◽  
Prolactin Release ◽  
Clinical Observations ◽  
Significant Difference ◽  
Before And After ◽  
Serotonergic Function

Prolactin release in response to fenfluramine hydrochloride (60 mg orally) and placebo was evaluated in 18 medication-free patients with RDC major depressive disorder, endogenous subtype, before and after a series of bilateral treatments with ECT. Before ECT, fenfluramine induced a twofold increase in plasma prolactin levels. This response was significantly enhanced after the ECT series, while baseline prolactin levels and response to the placebo challenge were not altered. There was no significant difference in plasma fenfluramine and norfenfluramine levels during the pre- and post-ECT challenges. These findings suggest that ECT enhances central serotonergic responsivity and extend to depressed patients pre-clinical observations regarding the effect of electroconvulsive shock on serotonergic function.

HMPAO SPECT in Parkinson’s disease (PD) with major depression (MD) before and after antidepressant treatment

2009 ◽  
Vol 256 (9) ◽  
pp. 1510-1518 ◽  
Author(s):  
Sven E. Pålhagen ◽  
Stefan Ekberg ◽  
Jan Wålinder ◽  
Ann-Kathrine Granérus ◽  
Göran Granerus
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Major Depression ◽  
Antidepressant Treatment ◽  
Hmpao Spect ◽  
Before And After
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