scholarly journals Late mortality of long-term survivors of childhood cancer

2011 ◽  
Vol 4 ◽  
pp. 240-245
Author(s):  
Maryna Krawczuk-Rybak
Keyword(s):  
Childhood Cancer ◽  
Late Mortality ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Late mortality of long-term survivors of childhood cancer.

1997 ◽  
Vol 15 (6) ◽  
pp. 2205-2213 ◽  
Author(s):  
M M Hudson ◽  
D Jones ◽  
J Boyett ◽  
G B Sharp ◽  
C H Pui
Keyword(s):  
Childhood Cancer ◽  
Unintentional Injury ◽  
Initial Therapy ◽  
Primary Malignancy ◽  
Late Mortality ◽  
Risk Of Death ◽  
Survivors Of Childhood Cancer ◽  
The Impact ◽  
Long Term Survivors

PURPOSE To determine the frequency and patterns of late mortality among long-term survivors of childhood cancer. MATERIALS AND METHODS Medical records of patients who survived at least 5 years after the diagnosis of childhood cancer were reviewed to determine the causes of subsequent deaths. Estimated 15-year survival and standardized mortality ratios for deaths from nonneoplastic treatment complications were compared with adjusted United States population estimates. The study included 2,053 patients who had survived > or = 5 years, grouped by treatment eras that reflected increased intensity of therapy and significantly improved survival (early era, 1962 to 1970; recent era, 1971 to 1983). RESULTS There have been 258 subsequent deaths in the 2,053 childhood cancer survivors; 169 occurred 5 to 10 years postdiagnosis and 89 > or = 10 years post diagnosis. For the study period as a whole, deaths were attributed to recurrent primary malignancy in 61% of cases, second malignancy in 20%, nonneoplastic treatment complication in 10%, and unintentional injury/suicide in 8%. Late death from recurrent disease decreased significantly for survivors treated in the recent era (P < .0001), while the risk of death from second malignancies increased, although not statistically significantly (P = .10). Projected 15-year survival estimates for all > or = 5-year survivors in both treatment eras was greater than 90%, but differed from expected rates. CONCLUSION Late mortality from recurrence after treatment for childhood cancer decreases with more effective initial therapy. Prolonged disease-free status is associated with an expected survival that approaches that of the general population for patients treated from 1971 through 1983. The impact of more recent intensified and novel therapies for high-risk patients remains to be determined.

scholarly journals No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment

Cancer ◽  
2018 ◽  
Vol 124 (17) ◽  
pp. 3576-3585 ◽  
Author(s):  
Fabiën N. Belle ◽  
Rahel Kasteler ◽  
Christina Schindera ◽  
Murielle Bochud ◽  
Roland A. Ammann ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Glucocorticoid Treatment ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Abstract 5949: Abnormal NT-Pro-BNP Levels in Asymptomatic Long Term Survivors of Childhood Cancer Treated with Anthracyclines

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Annelies M Mavinkurve-Groothuis ◽  
Jacqueline Groot-Loonen ◽  
Louise Bellersen ◽  
Milanthy S Pourier ◽  
Ton Feuth ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Late Onset ◽  
Troponin T ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Internal Diameter ◽  
List Type ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Objectives : to document plasma concentrations of cardiac Troponin T (cTnT) and NT-pro-brain natriuretic peptide (NT-pro-BNP) in a large group of asymptomatic long term survivors of childhood cancer treated with anthracyclines, to study the relation of the abnormal biomarker levels with different risk factors for anthracycline-induced cardiotoxicity and conventional echocardiographic parameters. Methods : 122 asymptomatic survivors of childhood cancer underwent a detailed echocardiography. Blood samples were taken to determine the levels of NT-pro-BNP and cTnT. Results : None of the survivors had abnormal cTnT levels. The mean NT-pro-BNP level of our survivor group was 10 pmol/l (SD±9) with a range of 1–55 pmol/l. Thirteen percent of the survivors had abnormal NT-pro-BNP levels. Abnormal NT-pro-BNP levels were significantly related to cumulative anthracycline dosage (p<0.003). Eleven of 31 (35%) survivors treated with cumulative anthracycline dose of 300 mg/m 2 or more, had abnormal NT-pro-BNP levels which were significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (p<0.01). Conclusion : Cardiac TnT does not contribute to the early detection of late onset anthracyline-induced cardiotoxicity. Abnormal levels of NT-pro-BNP were frequently detected in asymptomatic, long term survivors of childhood cancer. Follow up of these survivors, with both echocardiography and NT-pro-BNP, is essential to answer the question whether NT-pro-BNP is an early marker for late onset anthracycline-induced cardiotoxicity.

scholarly journals Diabetes Mellitus in Long-term Survivors of Childhood Cancer

2009 ◽  
Vol 169 (15) ◽  
pp. 1381 ◽  
Author(s):  
Lillian R. Meacham ◽  
Charles A. Sklar ◽  
Suwen Li ◽  
Qi Liu ◽  
Nora Gimpel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Childhood Cancer ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

scholarly journals Occurrence of Multiple Subsequent Neoplasms in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2011 ◽  
Vol 29 (22) ◽  
pp. 3056-3064 ◽  
Author(s):  
Gregory T. Armstrong ◽  
Wei Liu ◽  
Wendy Leisenring ◽  
Yutaka Yasui ◽  
Sue Hammond ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cumulative Incidence ◽  
Malignant Neoplasm ◽  
Childhood Cancer Survivors ◽  
Late Morbidity ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Purpose Childhood cancer survivors experience an increased incidence of subsequent neoplasms (SNs). Those surviving the first SN (SN1) remain at risk to develop multiple SNs. Because SNs are a common cause of late morbidity and mortality, characterization of rates of multiple SNs is needed. Patients and Methods In a total of 14,358 5-year survivors of childhood cancer diagnosed between 1970 and 1986, analyses were carried out among 1,382 survivors with an SN1. Cumulative incidence of second subsequent neoplasm (SN2), either malignant or benign, was calculated. Results A total of 1,382 survivors (9.6%) developed SN1, of whom 386 (27.9%) developed SN2. Of those with SN2, 153 (39.6%) developed more than two SNs. Cumulative incidence of SN2 was 46.9% (95% CI, 41.6% to 52.2%) at 20 years after SN1. The cumulative incidence of SN2 among radiation-exposed survivors was 41.3% (95% CI, 37.2% to 45.4%) at 15 years compared with 25.7% (95% CI, 16.5% to 34.9%) for those not treated with radiation. Radiation-exposed survivors who developed an SN1 of nonmelanoma skin cancer (NMSC) had a cumulative incidence of subsequent malignant neoplasm (SMN; ie, malignancies excluding NMSC) of 20.3% (95% CI, 13.0% to 27.6%) at 15 years compared with only 10.7% (95% CI, 7.2% to 14.2%) for those who were exposed to radiation and whose SN1 was an invasive SMN (excluding NMSC). Conclusion Multiple SNs are common among aging survivors of childhood cancer. SN1 of NMSC identifies a population at high risk for invasive SMN. Survivors not exposed to radiation who develop multiple SNs represent a population of interest for studying genetic susceptibility to neoplasia.

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