scholarly journals Elevated levels of serum transforming growth factor-β 1 in oesophageal squamous cell carcinoma patients

2011 ◽  
Vol 3 ◽  
pp. 137-141 ◽  
Author(s):  
Dorota Diakowska ◽  
Andrzej Lewandowski ◽  
Krystyna Markocka-Mączka ◽  
Krzysztof Grabowski
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Oesophageal Squamous Cell Carcinoma

Amplification and expression of the TGF-α, EGF receptor and c-myc genes in four human oesophageal squamous cell carcinoma lines

1993 ◽  
Vol 13 (5) ◽  
pp. 303-312 ◽  
Author(s):  
Gregory J. Jones ◽  
Nina S. Heiss ◽  
Robin B. Veale ◽  
Alan L. Thornley
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Gene Amplification ◽  
Squamous Cell ◽  
Egf Receptor ◽  
Transforming Growth Factor ◽  
Scatchard Analysis ◽  
Oesophageal Squamous Cell Carcinoma

We have previously shown that four human oesophageal squamous cell carcinoma (SCC) cell lines secrete significant quantities of transforming growth factor alpha (TGF-α) in vitro. Three of these lines are known to produce supernumary low-affinity epidermal growth factor receptors (EGF-Rs). Using an125I-EGF compeitive binding assay and Scatchard analysis, we show that the fourth also overproduces low-affinity receptors. According to slot blot DNA analyses, the secretion of high levels of TGF-α is not associated with amplification of the TGF-α gene, and hyperproduction of the EGF-R is correlated with receptor gene amplification. Western blot analyses show that the c-Myc protein is overexpressed in two of the cell lines; and Southern and Northern blot analyses indicate that this overexpression occurs independently of c-myc gene amplification. Our results are consistent with an autocrine role for TGF-α and EGF-R in oesophageal carcinogenesis and support the possibility that c-myc overexpression may be required for the in vivo tumourigenicity of cells that produce high levels of TGF-α and the EGF-R.

scholarly journals Transforming Growth Factor β Receptors in Verrucous and Squamous Cell Carcinoma

1999 ◽  
Vol 125 (8) ◽  
pp. 849 ◽  
Author(s):  
Meredith Anderson ◽  
Carlos Muro-Cacho ◽  
Joehassin Cordero ◽  
Sandra Livingston ◽  
Teresita Muñoz-Antonia
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

Differential Transforming Growth Factor-β Secretion in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

1997 ◽  
Vol 64 (3) ◽  
pp. 477-480 ◽  
Author(s):  
Alessandro D. Santin ◽  
Paul L. Hermonat ◽  
John C. Hiserodt ◽  
John Fruehauf ◽  
Viktor Schranz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β
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