scholarly journals Photodynamic therapy in the treatment of prostate cancer

2011 ◽  
Vol 2 ◽  
pp. 80-87 ◽  
Author(s):  
Andrzej M. Bugaj
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy

scholarly journals Selective Photodetection and Photodynamic Therapy for Prostate Cancer through Targeting of Proteolytic Activity

2012 ◽  
Vol 12 (3) ◽  
pp. 306-313 ◽  
Author(s):  
Maria-Fernanda Zuluaga ◽  
Nawal Sekkat ◽  
Doris Gabriel ◽  
Hubert van den Bergh ◽  
Norbert Lange
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Proteolytic Activity

Focal Therapy of Prostate Cancer by Radiofrequency and Photodynamic Therapy

2013 ◽  
pp. 727-751
Author(s):  
Bob Djavan ◽  
Herbert Lepor ◽  
Reza Zare ◽  
Seyed Saeid Dianat
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Focal Therapy

scholarly journals Decision Regret and Quality of Life after Focal Therapy with Vascular-Targeted Photodynamic Therapy (TOOKAD®) for Localized Prostate Cancer

2021 ◽  
pp. 1-6
Author(s):  
Luka Flegar ◽  
Martin Baunacke ◽  
Bjoern Thorben Buerk ◽  
Rick Proschmann ◽  
Aristeidis Zacharis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Decision Making ◽  
Photodynamic Therapy ◽  
Local Recurrence ◽  
Post Treatment ◽  
Decision Regret ◽  
Targeted Photodynamic Therapy ◽  
Decisional Regret

<b><i>Purpose:</i></b> The aim of the study was to assess quality of life (QoL), decision involvement, and decisional regret after treatment with vascular-targeted photodynamic therapy (VTP) (TOOKAD®) for unilateral low-risk prostate cancer. <b><i>Methods:</i></b> Validated questionnaires (EORTC QLQ-C30 and QLQ-PR25) capturing QoL post-treatment, involvement in decision-making (Control Preferences Scale) and decision regret (Decisional Regret Scale), were given to patients at the 12-month visit after undergoing VTP at our institution between May 2018 and February 2021. <b><i>Results:</i></b> Out of 44 patients, 36 patients were included in this study and 31 (86.1%) responded to the questionnaires. Mean overall health score capturing QoL at 12 months was 79.3 (standard deviation: ±18.1). 70.9% of the patients (<i>n</i> = 22) had no decision regret, and 67.8% of men (<i>n</i> = 21) had an active role in decision-making. In control biopsy at 12 months post-treatment, 19.4% of patients (<i>n</i> = 7) presented with local recurrence and progression to higher Gleason score (GS) was found in 13.8% of patients (<i>n</i> = 5). Patients (<i>n</i> = 3) presenting with tumor recurrence or progression to higher GS in control biopsy showed a significantly higher level of decision regret (<i>p</i> &#x3c; 0.009). <b><i>Conclusion:</i></b> Only 9.7% of men (<i>n</i> = 3) felt a strong emotion of regret at 12 months after VTP. Level of decision regret was significantly higher in patients with local recurrence or tumor progression detected in control biopsy. QoL was stable after VTP.

scholarly journals Focal Treatment of Prostate Cancer with Vascular-Targeted Photodynamic Therapy

2008 ◽  
Vol 8 ◽  
pp. 963-973 ◽  
Author(s):  
Scott E. Eggener ◽  
Jonathan A. Coleman
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Focal Therapy ◽  
Attractive Alternative ◽  
Screening Programs ◽  
Sexual Side Effects ◽  
Pathologic Features ◽  
Focal Treatment ◽  
Risk Of Progression ◽  
Targeted Photodynamic Therapy

Epidemiologic and pathologic features of prostate cancer have given rise to an interest in focal treatment for carefully selected patients. Prostate cancer remains highly prevalent, particularly in the U.S. and Europe. As screening programs have become more aggressive and widespread, a substantial proportion of men diagnosed with localized prostate cancer have disease characteristics associated with a low risk of progression. Treatments such as radical prostatectomy and radiation therapy can lead to durable recurrence-free survival in most patients, but carry variable risks of bowel, urinary, and sexual side effects. Few men and few urologists are comfortable leaving a potentially curable prostate cancer untreated. Focal therapy offers an attractive alternative for the patient faced with a choice between aggressive local intervention (radiation or surgery) and watchful waiting. Contemporary diagnostic biopsy strategies and imaging tools, and the development of predictive statistical models (nomograms), have led to improvements in tumor characterization and risk stratification, making focal therapy a viable treatment option for specific men. This article reviews the rationale and indications for focal therapy and highlights vascular-targeted photodynamic therapy (PDT) as one of many promising focal therapy techniques.

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