scholarly journals The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

2016 ◽  
Vol 4 ◽  
pp. 404-410 ◽  
Author(s):  
Katarzyna Malinowska ◽  
Michał Kowalski ◽  
Jerzy Szaflik ◽  
Jerzy P. Szaflik ◽  
Ireneusz Majsterek
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle

scholarly journals The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population

2014 ◽  
Vol 4 ◽  
pp. 313-321 ◽  
Author(s):  
Alicja Nowak ◽  
Karolina Przybylowska-Sygut ◽  
Katarzyna Szymanek ◽  
Jerzy Szaflik ◽  
Jacek P. Szaflik ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle ◽  
Relationship Of ◽  
The Relationship

scholarly journals BDNF and HSP gene polymorphisms and their influence on the progression of primary open-angle glaucoma in a Polish population

2014 ◽  
Vol 6 ◽  
pp. 1206-1213 ◽  
Author(s):  
Alicja Nowak ◽  
Jacek P. Szaflik ◽  
Mira Gacek ◽  
Karolina Przybylowska-Sygut ◽  
Anna Kamińska ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle

scholarly journals The role of the 148 Asp/Glu polymorphism of the APE1 gene in the development and progression of primary open angle glaucoma development in the Polish population

2013 ◽  
Vol 4 ◽  
pp. 296-302 ◽  
Author(s):  
Magda Cuchra ◽  
Jacek Pawel Szaflik ◽  
Karolina Przybylowska-Sygut ◽  
Mira Gacek ◽  
Anna Kaminska ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle

scholarly journals Association of MMP1-1607 1G/2G and TIMP1 372 T/C gene polymorphisms with risk of primary open angle glaucoma in a Polish population

2011 ◽  
Vol 17 (7) ◽  
pp. CR417-CR421 ◽  
Author(s):  
Ireneusz Majsterek ◽  
Lukasz Markiewicz ◽  
Karolina Przybylowska ◽  
Mira Gacek ◽  
Anna K. Kurowska ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle

scholarly journals Role of Fibronectin in Primary Open Angle Glaucoma

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1518 ◽  
Author(s):  
Jennifer A. Faralli ◽  
Mark S. Filla ◽  
Donna M. Peters
Keyword(s):  
United States ◽  
Trabecular Meshwork ◽  
Vision Loss ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
The United States ◽  
Open Angle ◽  
Cell Matrix ◽  
Fibronectin Fibrils

Primary open angle glaucoma (POAG) is the most common form of glaucoma and the 2nd most common cause of irreversible vision loss in the United States. Nearly 67 million people have the disease worldwide including >3 million in the United States. A major risk factor for POAG is an elevation in intraocular pressure (IOP). The increase in IOP is believed to be caused by an increase in the deposition of extracellular matrix proteins, in particular fibronectin, in a region of the eye known as the trabecular meshwork (TM). How fibronectin contributes to the increase in IOP is not well understood. The increased density of fibronectin fibrils is thought to increase IOP by altering the compliance of the trabecular meshwork. Recent studies, however, also suggest that the composition and organization of fibronectin fibrils would affect IOP by changing the cell-matrix signaling events that control the functional properties of the cells in the trabecular meshwork. In this article, we will discuss how changes in the properties of fibronectin and fibronectin fibrils could contribute to the regulation of IOP.

scholarly journals Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

Autophagy ◽  
2009 ◽  
Vol 5 (1) ◽  
pp. 122-124 ◽  
Author(s):  
Paloma B. Liton ◽  
Yizhi Lin ◽  
Pedro Gonzalez ◽  
David L. Epstein
Keyword(s):  
Potential Role ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Lysosomal Dysfunction
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