scholarly journals Intestinal healing after anti-TNF induction therapy predicts long-term response to one-year treatment in patients with ileocolonic Crohn’s disease naive to anti-TNF agents

2016 ◽  
Vol 3 ◽  
pp. 187-193 ◽  
Author(s):  
Piotr Eder ◽  
Liliana Łykowska-Szuber ◽  
Katarzyna Katulska ◽  
Kamila Stawczyk-Eder ◽  
Iwona Krela-Kaźmierczak ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Induction Therapy ◽  
One Year ◽  
Tnf Induction ◽  
Term Response

scholarly journals Improved Biochemical Parameters in Patients Who Undergo Early Resection in Isolated Ileocaecal Crohn’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Mirzafaraz Saeed ◽  
Hari Hullur ◽  
Amro Salem ◽  
Abbas Ali ◽  
Yousif Sahib ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Surgical Resection ◽  
Complete Blood Count ◽  
Long Term Results ◽  
Number Of Patients ◽  
Long Term Follow Up ◽  
One Year

Introduction. The aim of this study is to evaluate the outcome of introduction of early surgery in the course of isolated ileocecal Crohn’s disease, where there is no absolute indication of surgery. Methods. Observational study involving patients with isolated ileocecal Crohn’s disease who underwent early surgical resection (within one year of the presentation of the hospital). A complete blood count, ESR, and CRP were done and compared between the preoperative value, 1st postoperative visit (3-4 weeks), and last follow-up visit. Statistical analysis was done using Analysis of Variance (ANOVA) to compare the different figures. Results. There was a statistically significant increase in the hemoglobin levels between preoperative, postoperative, and long-term follow-up and a significant decrease in leukocyte count between the pre- and postoperative values (F=19.8, p<0.001 and F=8.9, p=0.002, resp.). Similarly, the ESR and CRP values were decreased significantly at long-term follow-up (F=8.5, p=0.019 and F=8.3, p=0.013, resp.). Conclusion. Early surgical resection in isolated ileocaecal Crohn’s disease achieved significant biochemical improvements. These successful results in this small number of patients indicate that early surgical intervention may provide better outcomes. These initial results encourage larger and comparative studies of long-term results versus long-term use of biological agents.

Genetic predictors of long-term response and trough levels of infliximab in crohn’s disease

2019 ◽  
Vol 149 ◽  
pp. 104478 ◽  
Author(s):  
Sara Salvador-Martín ◽  
Beatriz López-Cauce ◽  
Olga Nuñez ◽  
Emilio J. Laserna-Mendieta ◽  
María I. García ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genetic Predictors ◽  
Trough Levels ◽  
Term Response

954 Infliximab Maintenance Beyond One Year Prevents Postoperative Crohn's Disease Recurrence: Long-Term Follow-up From the Randomized Controlled Pilot Study

2013 ◽  
Vol 144 (5) ◽  
pp. S-173 ◽  
Author(s):  
Miguel Regueiro ◽  
Leonard Baidoo ◽  
Kevin E. Kip ◽  
Jason M. Swoger ◽  
David G. Binion ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Pilot Study ◽  
Crohn's Disease ◽  
Disease Recurrence ◽  
Randomized Controlled ◽  
Long Term Follow Up ◽  
One Year

Su1894 - Therapeutic Gain of Continued, Long-Term Infliximab Therapy in Crohn's Disease Patients with Response but Nonremission after One Year of Infliximab Therapy

2018 ◽  
Vol 154 (6) ◽  
pp. S-623-S-624
Author(s):  
Sine Buhl ◽  
Märta K. Borghede ◽  
Jorn Brynskov ◽  
Casper Steenholdt ◽  
Maria Rasmussen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Infliximab Therapy ◽  
Therapeutic Gain ◽  
One Year

M1160 Immediate and Long-Term Response to Corticosteroid Therapy in Pediatric Crohn's Disease Patients

2009 ◽  
Vol 136 (5) ◽  
pp. A-363
Author(s):  
Alfreda Krupoves ◽  
Ernest G. Seidman ◽  
Colette Deslandres ◽  
Vytautas Bucionis ◽  
Devendra K. Amre
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Corticosteroid Therapy ◽  
Term Response

scholarly journals Long term response of Crohn's disease to treatment with 6-mercaptopurine

1978 ◽  
Vol 74 (5) ◽  
pp. 1130 ◽  
Author(s):  
B.I. Korelitz ◽  
N. Wisch ◽  
J.L. Glass ◽  
D.H. Present
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Term Response

scholarly journals DOP070 Endoscopic response to induction therapy with TNF inhibitors is the best predictor of long term mucosal healing in Crohn's disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S67-S68
Author(s):  
I. Alfaro ◽  
M. Masamunt ◽  
N. Planell ◽  
A. Lόpez-García ◽  
J. Castro ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Induction Therapy ◽  
Mucosal Healing ◽  
Tnf Inhibitors

scholarly journals Fecal Microbiota Transplantation is a Promising Switch Therapy for Patients with Prior Failure of Infliximab in Crohn’s Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Qianqian Li ◽  
Xiao Ding ◽  
Yujie Liu ◽  
Cicilia Marcella ◽  
Min Dai ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Remission ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Clinical Factors ◽  
Switch Therapy ◽  
Treatment Stage ◽  
One Year

Background: How to handle patients with anti-tumor necrosis factor (anti-TNF) failure was a common challenge to clinicians in Crohn’s disease (CD). The present study is dedicated to clarifying whether fecal microbiota transplantation (FMT) could be a switch therapy for patients with prior failure of infiiximab (IFX) in CD in a long-term observation.Methods: Thirty-six patients with CD who had prior failure of IFX were recruited from January 2013 to December 2019. The “one-hour FMT protocol” was followed in all patients. All patients received the first course of FMT through gastroscopy or mid-gut transendoscopic enteral tubing. After April 2014, the methodology of FMT was coined as washed microbiota transplantation (WMT), substituting for the manual methods, which is dependent on the automatic microbiota purification system and the washing process. The primary endpoint of this study was the clinical remission at one month and one year after FMT. The secondary endpoint was the safety of FMT in the short and long term, and clinical factors as predictors for long-term efficacy of FMT. Clinical factors as independent predictors of efficacy from FMT were isolated using univariable and multivariable logistic regression analysis.Results: There was no significant difference in the rates of clinical response and remission between IFX treatment stage and FMT treatment stage (at one month, three months and six months after administration) (p &gt; 0.05). Compared with those of 19 patients who achieved clinical remission at one month after FMT, the rates of clinical relapse were significantly higher in 18 patients who achieved clinical remission at one month after IFX [log-rank test p = 0.0009 HR = 3.081 (95% CI 1.43–6.639)]. Multivariate analysis revealed that the gender of donor (95% CI: 0.001–0.72; p = 0.031) was an independent predictor of efficacy at one year after FMT. No serious adverse events (AEs) associated with FMT were observed during and after FMT. The rate of AEs was significantly lower in group FMT than that in group IFX (p = 0.002).Conclusion: The present findings first time provided the evidence for clinicians to consider FMT into practice as an alternative switch therapy for patients with prior loss of response or intolerance to IFX in CD.Clinical Trial Registration:https://clinicaltrials.gov, identifier NCT01793831

Diffusion-weighted magnetic resonance enterocolonography in predicting remission after anti-TNF induction therapy in Crohn's disease

2016 ◽  
Vol 48 (3) ◽  
pp. 260-266 ◽  
Author(s):  
Anthony Buisson ◽  
Constance Hordonneau ◽  
Marion Goutte ◽  
Julien Scanzi ◽  
Felix Goutorbe ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Induction Therapy ◽  
Diffusion Weighted ◽  
Tnf Induction
Sign in / Sign up

Export Citation Format

Share Document