scholarly journals Renal cell carcinoma metastases to the pancreas and the thyroid gland 19 years after the primary tumour

2015 ◽  
Vol 3 ◽  
pp. 185-189
Author(s):  
Sylwia Wolf ◽  
Lukasz Obolonczyk ◽  
Krzysztof Sworczak ◽  
Piotr Czapiewski ◽  
Zbigniew Sledzinski
2013 ◽  
Vol 2013 (jan25 1) ◽  
pp. bcr2012007569-bcr2012007569 ◽  
Author(s):  
V. Di Stasi ◽  
A. D'Antonio ◽  
A. Caleo ◽  
L. Valvano

2018 ◽  
Vol 12 (7) ◽  
pp. E348-8 ◽  
Author(s):  
Nathan Grimes ◽  
Cathal Hannan ◽  
Matthew Tyson ◽  
Ali Thwaini

Introduction: Prognosis in patients with cancer is influenced by underlying tumour biology and also the host inflammatory response to the disease. There is limited evidence to suggest that an elevated neutrophil-lymphocyte ratio (NLR) predicts a poorer prognosis in patients undergoing nephrectomy for renal cell carcinoma (RCC). The aim of this paper is to investigate if patients undergoing nephrectomy for RCC with NLR ≤4 have a better overall and recurrence-free survival than patients with NLR >4.Methods: All patients who underwent nephrectomy at a single centre between January 1, 2011 and December 31, 2014 were identified. Patients were included if postoperative histology demonstrated RCC and if preoperative NLR was available. Patients were excluded if nephrectomy was not curative intent (i.e., cytoreductive nephrectomy), if primary tumour was graded to be T3b‒4 disease, if there was presence of nodal or metastatic disease on preoperative staging, or if adequate followup notes were not available. Primary and secondary outcomes were overall survival and recurrence-free survival, respectively.Results: A total of 154 patients were included in analysis of overall survival; 146 patients were included in analysis of recurrence-free survival. Patients with NLR ≤4 had a much better overall survival than patients with NLR >4 (95% vs. 78%; p=0.0219). Patients with NLR >4 also had higher rates of recurrence (p=0.0218).Conclusions: NLR may be a useful tool in identifying patients who may benefit from more frequent surveillance in the early postoperative period and may allow clinicians to offer surveillance schemes tailored to the individual patient.


2011 ◽  
Vol 3 (2) ◽  
pp. 93-95 ◽  
Author(s):  
Bulent Citgez ◽  
Mehmet Uludag ◽  
Gurkan Yetkin ◽  
Esin Kabul Gurbulak ◽  
Banu Yılmaz Ozguven ◽  
...  

ABSTRACT Metastases to the thyroid gland are rare. We report the case of a 50-year-old man with an isolated thyroid metastasis from renal cell carcinoma (RCC), 3 years after radical nephrectomy for the primary disease. Although uncommon, if a patient with a previous history of malignancy has a new thyroid mass, it should be considered metastatic tumor of recurrent malignancy until proved otherwise.


Cancer ◽  
2002 ◽  
Vol 95 (9) ◽  
pp. 1869-1878 ◽  
Author(s):  
Clara S. Heffess ◽  
Bruce M. Wenig ◽  
Lester D. Thompson

2020 ◽  
Vol 56 ◽  
pp. 194-196
Author(s):  
Ammar H. Habibullah ◽  
Sherif K. Abdelmonim ◽  
Ahmad Aldajani ◽  
Mohannad Rajab ◽  
Mohammad Alessa ◽  
...  

2008 ◽  
Vol 14 (8) ◽  
pp. 1040-1046 ◽  
Author(s):  
Neal Murari Duggal ◽  
Mark Horattas

2016 ◽  
Vol 41 (7) ◽  
pp. 583-584 ◽  
Author(s):  
Gowri L. Kanthan ◽  
Geoffrey Paul Schembri ◽  
Jaswinder Samra ◽  
Paul Roach ◽  
Edward Hsiao

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Carlos Zamarrón ◽  
Ihab Abdulkader ◽  
María C. Areses ◽  
Vanesa García-Paz ◽  
Luís León ◽  
...  

Clear cell renal cell carcinoma (CCRCC) is the most common origin for metastasis in the thyroid. A 51-year-old woman was referred to our hospital for a subcarinal lesion. Ten years before, the patient had undergone a nephrectomy for CCRCC. Whole-body fluorodeoxyglucose positron emission tomography revealed elevated values in the thyroid gland, while the mediastinum was normal. An endoscopic ultrasonography-guided fine-needle aspiration biopsy of the mediastinal mass was consistent with CCRCC, and this was confirmed after resection. The thyroidectomy specimen also revealed lymphocytic thyroiditis, nodular hyperplasia, one follicular adenoma, two papillary microcarcinomas, and six foci of metastatic CCRCC involving both thyroid lobes. Curiously two of the six metastatic foci were located inside two adenomatoid nodules (tumor-in-tumor). The metastatic cells were positive for cytokeratins, CD10, epidermal growth factor receptor, and vascular endothelial growth factor receptor 2. NoBRAFgene mutations were found in any of the primary and metastatic lesions. The patient was treated with sunitinib and finally died due to CCRCC distant metastases 6 years after the thyroidectomy. In CCRCC patients, a particularly prolonged survival rate may be achieved with the appropriate therapy, in contrast to the ominous prognosis typically found in patients with thyroid metastases from other origins.


2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Aleena Jallu ◽  
Manzoor Latoo ◽  
Rafiq Pampori

Introduction.Renal cell carcinoma accounts for approximately 3% of adult malignancies and 90–95% of neoplasms arising from the kidney. This disease is characterized by a lack of early warning signs, diverse clinical manifestations, and resistance to radiation and chemotherapy. Approximately one-third of patients with renal cell carcinoma have metastatic disease at initial presentation. Fifteen percent of patients with renal cell carcinoma are said to present with metastases in the head and neck region. Most of the metastases from RCC to the head and neck involve the thyroid gland. The head and neck are unusual sites for metastases, but skin, skeletal muscle, thyroid gland, nasal cavity and paranasal sinus metastases have been reported.Case Report.The following report describes a rare case where the patient presented with mandibular swelling of short duration as the primary complaint without any symptom or sign pertaining to urinary tract and was found to have renal cell carcinoma on further workup.Conclusion.Metastatic renal cell carcinoma is a diagnostic dilemma especially when there is no pointer historically towards renal cell carcinoma as was in our case. An unusual vascular osteolytic lesion in head and neck in a middle-aged person should be dealt with high index of suspicion with renal cell carcinoma at the back of the mind.


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