scholarly journals Allergic diseases – current state of knowledge

2012 ◽  
Vol 6 ◽  
pp. 451-455 ◽  
Author(s):  
Wioletta Żukiewicz-Sobczak ◽  
Ewelina Krasowska ◽  
Jacek Zwoliński ◽  
Paweł Sobczak ◽  
Jolanta Chmielewska-Badora ◽  
...  
Keyword(s):  
Allergic Diseases ◽  
Current State

scholarly journals Current State of Monoclonal Antibody Therapy for Allergic Diseases

Engineering ◽  
2021 ◽  
Author(s):  
Yan Chen ◽  
Wei Wang ◽  
Huihui Yuan ◽  
Yan Li ◽  
Zhe Lv ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Antibody Therapy ◽  
Allergic Diseases ◽  
Monoclonal Antibody Therapy ◽  
Current State

scholarly journals T Cell Repertoire During Ontogeny and Characteristics in Inflammatory Disorders in Adults and Childhood

2021 ◽  
Vol 11 ◽  
Author(s):  
Svenja Foth ◽  
Sara Völkel ◽  
Daniel Bauersachs ◽  
Michael Zemlin ◽  
Chrysanthi Skevaki
Keyword(s):  
T Cell ◽  
Cellular Immunity ◽  
Allergic Diseases ◽  
Chronic Infections ◽  
Cell Repertoire ◽  
Advantages And Disadvantages ◽  
Current State ◽  
Cell Immunity ◽  
Tcr Repertoire

Since the first day of life, a newborn has to deal with various pathogens from the environment. While passive immune protection is provided by diaplacental maternal antibodies, the development of cellular immunity is ongoing. A mature immune system should be able not only to defend against pathogens, but should also be able to differentiate between self- and non-self-antigens. Dysregulation in the development of cellular immunity can lead to severe disorders like immunodeficiency, autoimmunity and chronic inflammation. In this review, we explain the role of T cell immunity in antigen detection and summarize the characteristics of a mature TCR repertoire as well as the current state of knowledge about the development of the TCR repertoire in ontogenesis. In addition, methods of assessments are outlined, with a focus on the advantages and disadvantages of advanced methods such as next generation sequencing. Subsequently, we provide an overview of various disorders occuring in early childhood like immunodeficiencies, autoimmunity, allergic diseases and chronic infections and outline known changes in the TCR repertoire. Finally, we summarize the latest findings and discuss current research gaps as well as potential future developments.

Oral Immunotherapy for Allergic Diseases Using Transgenic Rice Seeds: Current State and Future Prospects

2013 ◽  
Vol 161 (s2) ◽  
pp. 164-169 ◽  
Author(s):  
Mayumi Saeki ◽  
Tomoe Nishimura ◽  
Osamu Kaminuma ◽  
Akio Mori ◽  
Takachika Hiroi
Keyword(s):  
Transgenic Rice ◽  
Allergic Diseases ◽  
Oral Immunotherapy ◽  
Future Prospects ◽  
Current State ◽  
Rice Seeds

scholarly journals The current state of omics technologies in the clinical management of asthma and allergic diseases

2019 ◽  
Vol 123 (6) ◽  
pp. 550-557 ◽  
Author(s):  
Brittney M. Donovan ◽  
Lisa Bastarache ◽  
Kedir N. Turi ◽  
Mary M. Zutter ◽  
Tina V. Hartert
Keyword(s):  
Clinical Management ◽  
Allergic Diseases ◽  
Omics Technologies ◽  
Current State

scholarly journals Allergen-Specific Child Immunotherapy: Current State of Affairs

2016 ◽  
Vol 13 (4) ◽  
pp. 404-408
Author(s):  
E. A. Vishneva ◽  
L. S. Namazova-Baranova ◽  
A. A. Alekseeva ◽  
L. R. Selimzyanova ◽  
J. G. Levina ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Medical Technology ◽  
Pediatric Patients ◽  
Specific Immunotherapy ◽  
Allergic Diseases ◽  
Immunological Tolerance ◽  
Research Development ◽  
Allergen Specific Immunotherapy ◽  
Current State ◽  
State Of Affairs

The article is devoted to allergen-specific immunotherapy (ASIT) — the only etiopathogenic therapy method for allergic diseases. By promoting the formation of immunological tolerance, ASIT modifies the course of the disease, prevents the occurrence of new or the worsening of existing sensitizations, thereby preventing the development of asthma, which is especially important for pediatric patients. The authors present the mechanism of action and its main features and conditions with regard to achieving the planned effect. Considered are the key contraindications to ASIT, the principles of selecting the appropriate allergen for the treatment and features of its introduction to both children with mono sensitization and children sensitive to the allergen group. Further prospects of research development and existing achievements of this medical technology are mentioned.

ESEM - A multipurpose surface Electron Microscope

1986 ◽  
Vol 44 ◽  
pp. 632-633 ◽  
Author(s):  
G.D. Danilatos
Keyword(s):  
Electron Microscope ◽  
Room Temperature ◽  
Environmental Scanning ◽  
Gas Composition ◽  
Saturated Water Vapor ◽  
Surface Electron ◽  
Current State ◽  
Saturated Water ◽  
New Type ◽  
Temperature And Pressure

Over recent years a new type of electron microscope - the environmental scanning electron microscope (ESEM) - has been developed for the examination of specimen surfaces in the presence of gases. A detailed series of reports on the system has appeared elsewhere. A review summary of the current state and potential of the system is presented here.The gas composition, temperature and pressure can be varied in the specimen chamber of the ESEM. With air, the pressure can be up to one atmosphere (about 1000 mbar). Environments with fully saturated water vapor only at room temperature (20-30 mbar) can be easily maintained whilst liquid water or other solutions, together with uncoated specimens, can be imaged routinely during various applications.

Recent applications of TEM to the study of interfaces

1990 ◽  
Vol 48 (4) ◽  
pp. 308-309
Author(s):  
C. Barry Carter
Keyword(s):  
High Resolution ◽  
Sample Preparation ◽  
Grain Boundaries ◽  
Diffuse Scattering ◽  
Imaging Techniques ◽  
Amorphous Material ◽  
Contrast Imaging ◽  
Current State ◽  
Actual Nature ◽  
High Resolution Images

This paper will review the current state of understanding of interface structure and highlight some of the future needs and problems which must be overcome. The study of this subject can be separated into three different topics: 1) the fundamental electron microscopy aspects, 2) material-specific features of the study and 3) the characteristics of the particular interfaces. The two topics which are relevant to most studies are the choice of imaging techniques and sample preparation. The techniques used to study interfaces in the TEM include high-resolution imaging, conventional diffraction-contrast imaging, and phase-contrast imaging (Fresnel fringe images, diffuse scattering). The material studied affects not only the characteristics of the interfaces (through changes in bonding, etc.) but also the method used for sample preparation which may in turn have a significant affect on the resulting image. Finally, the actual nature and geometry of the interface must be considered. For example, it has become increasingly clear that the plane of the interface is particularly important whenever at least one of the adjoining grains is crystalline.A particularly productive approach to the study of interfaces is to combine different imaging techniques as illustrated in the study of grain boundaries in alumina. In this case, the conventional imaging approach showed that most grain boundaries in ion-thinned samples are grooved at the grain boundary although the extent of this grooving clearly depends on the crystallography of the surface. The use of diffuse scattering (from amorphous regions) gives invaluable information here since it can be used to confirm directly that surface grooving does occur and that the grooves can fill with amorphous material during sample preparation (see Fig. 1). Extensive use of image simulation has shown that, although information concerning the interface can be obtained from Fresnel-fringe images, the introduction of artifacts through sample preparation cannot be lightly ignored. The Fresnel-fringe simulation has been carried out using a commercial multislice program (TEMPAS) which was intended for simulation of high-resolution images.

Proteasome inhibitors as therapeutics

2005 ◽  
Vol 41 ◽  
pp. 205-218
Author(s):  
Constantine S. Mitsiades ◽  
Nicholas Mitsiades ◽  
Teru Hideshima ◽  
Paul G. Richardson ◽  
Kenneth C. Anderson
Keyword(s):  
Multiple Myeloma ◽  
Drug Class ◽  
Proteasome Inhibitors ◽  
Cell Cycle Regulators ◽  
Current State ◽  
Intracellular Mechanism ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Hodgkin's Lymphomas ◽  
Clinical Research Data

The ubiquitin–proteasome pathway is a principle intracellular mechanism for controlled protein degradation and has recently emerged as an attractive target for anticancer therapies, because of the pleiotropic cell-cycle regulators and modulators of apoptosis that are controlled by proteasome function. In this chapter, we review the current state of the field of proteasome inhibitors and their prototypic member, bortezomib, which was recently approved by the U.S. Food and Drug Administration for the treatment of advanced multiple myeloma. Particular emphasis is placed on the pre-clinical research data that became the basis for eventual clinical applications of proteasome inhibitors, an overview of the clinical development of this exciting drug class in multiple myeloma, and a appraisal of possible uses in other haematological malignancies, such non-Hodgkin's lymphomas.

Behavioral Genetics: Concepts for Research and Practice in Language Development and Disorders

1995 ◽  
Vol 38 (5) ◽  
pp. 1126-1142 ◽  
Author(s):  
Jeffrey W. Gilger
Keyword(s):  
Language Development ◽  
Behavioral Genetics ◽  
State Of The Art ◽  
Genetic Research ◽  
Great Promise ◽  
Behavioral Genetic ◽  
Fine Grained ◽  
Future Goals ◽  
Current State ◽  
Research Designs

This paper is an introduction to behavioral genetics for researchers and practioners in language development and disorders. The specific aims are to illustrate some essential concepts and to show how behavioral genetic research can be applied to the language sciences. Past genetic research on language-related traits has tended to focus on simple etiology (i.e., the heritability or familiality of language skills). The current state of the art, however, suggests that great promise lies in addressing more complex questions through behavioral genetic paradigms. In terms of future goals it is suggested that: (a) more behavioral genetic work of all types should be done—including replications and expansions of preliminary studies already in print; (b) work should focus on fine-grained, theory-based phenotypes with research designs that can address complex questions in language development; and (c) work in this area should utilize a variety of samples and methods (e.g., twin and family samples, heritability and segregation analyses, linkage and association tests, etc.).

The prevalence of allergic diseases in primary school children in Edirne, Turkey

1997 ◽  
Vol 27 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Z. TOROS SELCUK ◽  
T. CAG-LAR ◽  
T. ENUNLU ◽  
T. TOPAL
Keyword(s):  
Primary School ◽  
School Children ◽  
Allergic Diseases ◽  
Primary School Children
Sign in / Sign up

Export Citation Format

Share Document