scholarly journals Extracorporeal therapy for patients in deep hypothermia

2018 ◽  
Vol 34 (4) ◽  
pp. 349-352
Author(s):  
Ewelina Nowak ◽  
Edward Pietrzyk ◽  
Agnieszka Saługa ◽  
Izabela Wojarska ◽  
Paweł Łytek ◽  
...  
Keyword(s):  
Deep Hypothermia ◽  
Extracorporeal Therapy

scholarly journals Does deeper hypothermia reduce the risk of acute kidney injury after circulatory arrest for aortic arch surgery?

2021 ◽  
Author(s):  
Andrew M Vekstein ◽  
Babtunde A Yerokun ◽  
Oliver K Jawitz ◽  
Julie W Doberne ◽  
Jatin Anand ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Circulatory Arrest ◽  
Aortic Surgery ◽  
Multivariable Analysis ◽  
Kidney Injury ◽  
Deep Hypothermia ◽  
Moderate Hypothermia ◽  
Bladder Temperature ◽  
Increased Risk ◽  
The Impact

Abstract OBJECTIVES The impact of hypothermic circulatory arrest (HCA) temperature on postoperative acute kidney injury (AKI) has not been evaluated. This study examined the association between circulatory arrest temperatures and AKI in patients undergoing proximal aortic surgery with HCA. METHODS A total of 759 consecutive patients who underwent proximal aortic surgery (ascending ± valve ± root) including arch replacement requiring HCA between July 2005 and December 2016 were identified from a prospectively maintained institutional aortic surgery database. The primary outcome was AKI as defined by Risk, Injury, Failure, Loss, End Stage Renal Disease (ESRD) criteria. The association between minimum nasopharyngeal (NP) and bladder temperatures during HCA and postoperative AKI was assessed, adjusting for patient-level factors using multivariable logistic regression. RESULTS A total of 85% (n = 645) of patients underwent deep hypothermia (14.1–20.0°C), 11% (n = 83) low-moderate hypothermia (20.1–24.0°C) and 4% (n = 31) high-moderate hypothermia (24.1–28.0°C) as classified by NP temperature. When analysed by bladder temperature, 59% (n = 447) underwent deep hypothermia, 22% (n = 170) low-moderate, 16% (n = 118) high-moderate and 3% mild (n = 24) (28.1–34.0°C) hypothermia. The median systemic circulatory arrest time was 17 min. The incidence of AKI did not differ between hypothermia groups, whether analysed using minimum NP or bladder temperature. In the multivariable analysis, the association between degree of hypothermia and AKI remained non-significant whether analysed as a categorical variable (hypothermia group) or as a continuous variable (minimum NP or bladder temperature) (all P > 0.05). CONCLUSIONS In patients undergoing proximal aortic surgery including arch replacement requiring HCA, degree of systemic hypothermia was not associated with the risk of AKI. These data suggest that moderate hypothermia does not confer increased risk of AKI for patients requiring circulatory arrest, although additional prospective data are needed.

scholarly journals Selective deep hypothermia of the spinal cord prevents paraplegia after aortic cross-clamping in the dog model

1992 ◽  
Vol 15 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Ramon Berguer ◽  
Jose Porto ◽  
Brian Fedoronko ◽  
Ljubisa Dragovic
Keyword(s):  
Spinal Cord ◽  
Deep Hypothermia ◽  
Dog Model

Effects of deep hypothermia on nitric oxide-induced cytotoxicity in primary cultures of cortical neurons

2003 ◽  
Vol 72 (5) ◽  
pp. 613-621 ◽  
Author(s):  
Sriranganathan Varathan ◽  
Satoshi Shibuta ◽  
Vidya Varathan ◽  
Motohide Takemura ◽  
Norifumi Yonehara ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cortical Neurons ◽  
Primary Cultures ◽  
Deep Hypothermia

scholarly journals Neonatal Aortic Arch Reconstruction With Direct Splanchnic Perfusion Avoids Deep Hypothermia

2017 ◽  
Vol 104 (6) ◽  
pp. 2054-2063 ◽  
Author(s):  
Muhammad Aanish Raees ◽  
Clinton D. Morgan ◽  
Venessa L. Pinto ◽  
Ashly C. Westrick ◽  
Chevis N. Shannon ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Deep Hypothermia ◽  
Splanchnic Perfusion ◽  
Aortic Arch Reconstruction ◽  
Arch Reconstruction

Continuous Pulmonary Infusion of L-Arginine During Deep Hypothermia and Circulatory Arrest Improves Pulmonary Surfactant Integrity in Piglets

2008 ◽  
Vol 86 (2) ◽  
pp. 429-435 ◽  
Author(s):  
Yanmin Yang ◽  
Zhaokang Su ◽  
Jiming Cai ◽  
Shunmin Wang ◽  
Jinfen Liu ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Circulatory Arrest ◽  
Deep Hypothermia

Moderate vs Deep Hypothermia in Type A Acute Aortic Dissection Repair: Insights from IRAD

2021 ◽  
Author(s):  
Stevan S. Pupovac ◽  
Jonathan M. Hemli ◽  
Joseph E. Bavaria ◽  
Himanshu J. Patel ◽  
Santi Trimarchi ◽  
...  
Keyword(s):  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Type A ◽  
Deep Hypothermia

Effect of arterial carbon dioxide tension on cerebral blood flow during deep hypothermia

Cryobiology ◽  
1978 ◽  
Vol 15 (6) ◽  
pp. 715 ◽  
Author(s):  
Y. Kawashima ◽  
H. Yoshikawa ◽  
I. Kosugi ◽  
K. Okada ◽  
T. Kitagaki ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Carbon Dioxide Tension ◽  
Deep Hypothermia ◽  
Arterial Carbon Dioxide Tension ◽  
Arterial Carbon Dioxide

Microvascular fluid exchange during CPB with deep hypothermia circulatory arrest or low flow

Perfusion ◽  
2017 ◽  
Vol 32 (8) ◽  
pp. 661-669
Author(s):  
Bjørg Elvevoll ◽  
Paul Husby ◽  
Venny L. Kvalheim ◽  
Lodve Stangeland ◽  
Arve Mongstad ◽  
...  
Keyword(s):  
Brain Injury ◽  
Circulatory Arrest ◽  
Deep Hypothermia ◽  
Low Flow ◽  
Cerebral Microdialysis ◽  
Tissue Water ◽  
Fluid Exchange ◽  
Fluid Extravasation ◽  
Total Tissue ◽  
Water Contents

Objective: Use of deep hypothermic low-flow (DHLF) cardiopulmonary bypass (CPB) has been associated with higher fluid loading than the use of deep hypothermia circulatory arrest (DHCA). We evaluated whether these perfusion strategies influenced fluid extravasation rates and edema generation differently per-operatively. Materials and Methods: Twelve anesthetized pigs, randomly allocated to DHLF (n = 6) or DHCA (n = 6), underwent 2.5 hours CPB with cooling to 20°C for 30 minutes (min), followed by 30 min arrested circulation (DHCA) or 30 min low-flow circulation (DHLF) before 90 min rewarming to normothermia. Perfusion of tissues, fluid requirements, plasma volumes, colloid osmotic pressures and total tissue water contents were recorded and fluid extravasation rates calculated. During the experiments, cerebral microdialysis was performed in both groups. Results: Microvascular fluid homeostasis was similar in both groups, with no between-group differences, reflected by similar fluid extravasation rates, plasma colloid osmotic pressures and total tissue water contents. Although extravasation rates increased dramatically from 0.10 (0.11) ml/kg/min (mean with standard deviation in parentheses) and 0.16 (0.02) ml/kg/min to 1.28 (0.58) ml/kg/min and 1.06 (0.41) ml/kg/min (DHCA and DHLF, respectively) after the initiation of CPB, fluid filtrations during both cardiac arrest and low flow were modest and close to baseline values. Cerebral microdialysis indicated anaerobic metabolism and ischemic brain injury in the DHCA group. Conclusion: No differences in microvascular fluid exchange could be demonstrated as a direct effect of DHCA compared with DHLF. Thirty minutes of DHCA was associated with anaerobic cerebral metabolism and possible brain injury.

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