scholarly journals Genetic determination of pancreatic cancer

2018 ◽  
Vol 34 (2) ◽  
pp. 178-182
Author(s):  
Stanisław Głuszek ◽  
Dorota Kozieł
Keyword(s):  
Pancreatic Cancer ◽  
Genetic Determination

Pankreaskarzinom: Internistische und chirurgische Onkologen können gemeinsam mehr erreichen

2020 ◽  
Vol 7 (4) ◽  
pp. 201-203
Author(s):  
Hans-Rudolf Raab
Keyword(s):  
Pancreatic Cancer ◽  
Interrater Reliability ◽  
Locally Advanced ◽  
Advanced Pancreatic Cancer ◽  
Vascular Tumor ◽  
Locally Advanced Pancreatic Cancer ◽  
Borderline Resectable ◽  
Uniform Dispersion ◽  
Mri Scans

<b>Background:</b> One critical step in the therapy of patients with localized pancreatic cancer is the determination of local resectability. The decision between primary surgery versus upfront local or systemic cancer therapy seems especially to differ between pancreatic cancer centers. In our cohort study, we analyzed the independent judgement of resectability of five experienced high volume pancreatic surgeons in 200 consecutive patients with borderline resectable or locally advanced pancreatic cancer. <b>Methods:</b> Pretherapeutic CT or MRI scans of 200 consecutive patients with borderline resectable or locally advanced pancreatic cancer were evaluated by 5 independent pancreatic surgeons. Resectability and the degree of abutment of the tumor to the venous and arterial structures adjacent to the pancreas were reported. Interrater reliability and dispersion indices were compared. <b>Results:</b> One hundred ninety-four CT scans and 6 MRI scans were evaluated and all parameters were evaluated by all surgeons in 133 (66.5%) cases. Low agreement was observed for tumor infiltration of venous structures (κ = 0.265 and κ = 0.285) while good agreement was achieved for the abutment of the tumor to arterial structures (interrater reliability celiac trunk κ = 0.708 P &#x3c; 0.001). In patients with vascular tumor contact indicating locally advanced disease, surgeons highly agreed on unresectability, but in patients with vascular tumor abutment consistent with borderline resectable disease, the judgement of resectability was less uniform (dispersion index locally advanced vs. borderline resectable p &#x3c; 0.05). <b>Conclusion:</b> Excellent agreement between surgeons exists in determining the presence of arterial abutment and locally advanced pancreatic cancer. The determination of resectability in borderline resectable patients is influenced by additional subjective factors. <b>Trial registration:</b> EudraCT: 2009–014476–21 (2013–02–22) and NCT01827553 (2013–04–09).

scholarly journals Relationship Between Root and Yield Related Morphological Characters in Pea (Pisum Sativum L.)

2014 ◽  
Vol 66 (1) ◽  
pp. 3-15
Author(s):  
Sylwia Ciaglo-Androsiuk
Keyword(s):  
Root System ◽  
Morphological Traits ◽  
Lateral Roots ◽  
Morphological Characters ◽  
Yield Potential ◽  
Cultivated Plants ◽  
Genetic Determination ◽  
Canonical Correlations ◽  
Effect On Yield

AbstractRelation between morphological traits of the root system and yield related traits is an important issue concerning efforts aiming at improving of ideotype of cultivated plants species, including pea. In this paper, to analyse the dependency between traits describing the root system morphology and yield potential, Person’s andSpearman's_correlations as well as canonical correlations were used.Root system was analyzed in 14 and 21 day-old seedlings growing in blotting-paper cylinders. Yield potential of pea was analysed in a field experiment. Results of Person’s and Spearman's_correlations revealed that number of lateral roots and lateral roots density were correlated witch yield related traits. Correlation between root length and shoot length was observed only for 14 day-old seedlings. The result of canonical correlations revealed that number of lateral roots and lateral roots density had the largest effect on yield related traits. This work highlights, that in order to improve the yield of pea it might become necessary to understand genetic determination of morphological traits of the root system, especially number of lateral roots.

scholarly journals A Co-Association Network Analysis of the Genetic Determination of Pig Conformation, Growth and Fatness

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114862 ◽  
Author(s):  
Anna Puig-Oliveras ◽  
Maria Ballester ◽  
Jordi Corominas ◽  
Manuel Revilla ◽  
Jordi Estellé ◽  
...  
Keyword(s):  
Network Analysis ◽  
Association Network ◽  
Genetic Determination

GENETICS AND METABOLISM

PEDIATRICS ◽  
1960 ◽  
Vol 25 (4) ◽  
pp. 565-571
Author(s):  
Barton Childs
Keyword(s):  
Mutant Gene ◽  
Human Populations ◽  
Affected Patient ◽  
Adrenal Hyperplasia ◽  
Genetic Determination ◽  
The Subject ◽  
Definition Of ◽  
Genetically Determined ◽  
Or Genes

IT IS the part of wisdom when about to give a dissertation which one hopes will at once instruct and entertain, to provide at the outset some definition of the subject matter. Genetics is the study of the heritable components of variation; the heritable factors which determine the range or extent of diversity. So, genetics is concerned with heritable differences and likenesses between individuals and between species. One emphasizes the differences because one can be certain of genetic determination of a particular characteristic only when it exists in a population in two or more alternative forms. It is the variants which catch the eye and hold the attention of the investigator, and which by their presence suggest more than one form of the gene or genes which determine that particular characteristic. I would like in what follows to present some examples of investigations of some aspects of genetics in human populations. ADRENAL HYPERPLASIA Several years ago Dr. Melvin Grumbach and I studied the genetics of adrenal hyperplasia, using as our material the patients of Dr. Lawson Wilkins. Since the disease occurs in more than one member of a sibship and since parents are unaffected, we suspected that it was genetically determined and that the affected patient possessed a double dose of a mutant gene; that is, the characteristic was recessive.

Genetic determination of nephrogenesis: the Pax/Eya/Six gene network

2004 ◽  
Vol 19 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Stephan Brodbeck ◽  
Christoph Englert
Keyword(s):  
Gene Network ◽  
Genetic Determination
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