scholarly journals Aquatic and land aerobic training for patients with chronic low back pain: a randomized study

2019 ◽  
Vol 20 (1) ◽  
pp. 1-8
Author(s):  
Ana Carolina Kanitz ◽  
Bruna Machado Barroso ◽  
Guano Zambelli Barbosa ◽  
Andre Ivaniski Mello ◽  
Natalia Carvalho Bagatini ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Aerobic Training ◽  
Randomized Study ◽  
Low Back

scholarly journals Controlled-Release Oxycodone and Naloxone in the Treatment of Chronic Low Back Pain: A Placebo-Controlled, Randomized Study

2013 ◽  
Vol 18 (2) ◽  
pp. 75-82 ◽  
Author(s):  
C Cloutier ◽  
J Taliano ◽  
W O’Mahony ◽  
M Csanadi ◽  
G Cohen ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Controlled Release ◽  
Chronic Low Back Pain ◽  
Randomized Study ◽  
Analgesic Efficacy ◽  
Opioid Therapy ◽  
Low Back ◽  
Open Label ◽  
Double Blinded

BACKGROUND: For Canadian regulatory purposes, an analgesic study was required to complement previously completed, pivotal studies on bowel effects and analgesia associated with controlled-release (CR) oxycodone/CR naloxone.OBJECTIVES: To compare the analgesic efficacy and safety of CR oxycodone/CR naloxone versus placebo in patients with chronic low back pain.METHODS: Patients requiring opioid therapy underwent a two- to seven-day opioid washout before being randomly assigned to receive either 10 mg/5 mg CR oxycodone/CR naloxone or placebo every 12 h, titrated weekly according to efficacy and tolerability to 20 mg/10 mg, 30 mg/15 mg or 40 mg/20 mg every 12 h. After four weeks, patients crossed over to the alternative treatment for an additional four weeks. Acetaminophen/codeine (300 mg/30 mg every 4 h to 6 h as needed) was provided as rescue medication.RESULTS: Of the 83 randomized patients, 54 (65%) comprised the per-protocol population. According to per-protocol analysis, CR oxycodone/CR naloxone resulted in significantly lower mean (± SD) pain scores measured on a visual analogue scale (48.6±23.1 mm versus 55.9±25.4 mm; P=0.0296) and five-point ordinal pain intensity scores (2.1±0.8 versus 2.4±0.9; P=0.0415) compared with placebo. After the double-blinded phase, patients and investigators both preferred CR oxycodone/CR naloxone over placebo. These outcomes continued in the 79% of patients who chose to continue receiving CR oxycodone/CR naloxone in a six-month, open-label evaluation.CONCLUSIONS: In patients complying with treatment as per protocol, CR oxycodone/CR naloxone was effective for the management of chronic low back pain of moderate or severe intensity.

A Randomized Study of Back School in Women With Chronic Low Back Pain

Spine ◽  
2008 ◽  
Vol 33 (15) ◽  
pp. 1617-1621 ◽  
Author(s):  
Sedigheh Sadar Tavafian ◽  
Ahmad Reza Jamshidi ◽  
Ali Montazeri
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Randomized Study ◽  
Low Back ◽  
Back School

scholarly journals Response to duloxetine in chronic low back pain: exploratory post hoc analysis of a Japanese Phase III randomized study

2017 ◽  
Vol Volume 10 ◽  
pp. 2157-2168 ◽  
Author(s):  
Toshinaga Tsuji ◽  
Naohiro Itoh ◽  
Mitsuhiro Ishida ◽  
Toshimitsu Ochiai ◽  
Shin-ichi Konno
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Randomized Study ◽  
Phase Iii ◽  
Low Back ◽  
Post Hoc Analysis ◽  
Post Hoc
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