scholarly journals Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men

2015 ◽  
Vol 4 ◽  
pp. 377-386 ◽  
Author(s):  
Tomasz Mikulski ◽  
Jan Dabrowski ◽  
Wojciech Hilgier ◽  
Andrzej Ziemba ◽  
Krzysztof Krzeminski
Keyword(s):  
Amino Acids ◽  
Central Fatigue ◽  
Branched Chain Amino Acids ◽  
Plasma Ammonia ◽  
Healthy Men ◽  
Branched Chain

scholarly journals Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 35 ◽  
Author(s):  
Takuya Matsumoto ◽  
Koichi Nakamura ◽  
Hideki Matsumoto ◽  
Ryosei Sakai ◽  
Tomomi Kuwahara ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Branched Chain Amino Acids ◽  
Plasma Amino Acid ◽  
Healthy Men ◽  
Amino Acid Profiles ◽  
Branched Chain

scholarly journals Role of nutraceutical- branched chain amino acids for attenuating skeletal muscle soreness in post exercise status and central fatigue

2017 ◽  
Vol 7 (2) ◽  
pp. 19-23
Author(s):  
Satish Kumar Deo ◽  
Akritee Pokharel ◽  
Samir Lamichhane ◽  
Anish Mudvari
Keyword(s):  
Amino Acids ◽  
Muscle Soreness ◽  
Scientific Journal ◽  
Medical Science ◽  
Central Fatigue ◽  
Branched Chain Amino Acids ◽  
Human Volunteers ◽  
Neurochemical Changes ◽  
Branched Chain

Implementation of food extract for target medicinal purpose is a genre in medical science called Nutraceutical which is vast and much of it is yet to be explored. Nowadays general population are aware of the importance of exercise in terms of health benefits but the fatigue and delayed onset muscle soreness (DOMS) are limitations that are to be overcome to continue extensive exercises. For this article, the role of Branched chain amino acids (BCAA) for the purpose is studied from various scientific journal. DOMS is due to direct muscle damage following exercise whereas central fatigue is the sensation of fatigue due to neurochemical changes in brain following exercise. In various studies, DOMS and central fatigue were minimized in terms of duration when given to animals and human volunteers. Further research has to be done regarding dosing regimen of BCAA supplementation and also to uncover any adverse effect of the supplements.

scholarly journals Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km

1996 ◽  
Vol 81 (6) ◽  
pp. 2644-2650 ◽  
Author(s):  
Klavs Madsen ◽  
Dave A. Maclean ◽  
Bente Kiens ◽  
Dirk Christensen
Keyword(s):  
Amino Acids ◽  
Oxygen Uptake ◽  
Prolonged Exercise ◽  
Respiratory Exchange Ratio ◽  
Branched Chain Amino Acids ◽  
Plasma Ammonia ◽  
Exercise Period ◽  
Placebo Trial ◽  
Branched Chain ◽  
Performance Times

Madsen, Klavs, Dave A. MacLean, Bente Kiens, and Dirk Christensen. Effects of glucose, glucose plus branched-chain amino acids, or placebo on bike performance over 100 km. J. Appl. Physiol. 81(6): 2644–2650, 1996.—This study was undertaken to determine the effects of ingesting either glucose ( trial G) or glucose plus branched-chain amino acids (BCAA; trial B), compared with placebo ( trial P), during prolonged exercise. Nine well-trained cyclists with a maximal oxygen uptake of 63.1 ± 1.5 ml O2 ⋅ min−1 ⋅ kg−1performed three laboratory trials consisting of 100 km of cycling separated by 7 days between each trial. During these trials, the subjects were encouraged to complete the 100 km as fast as possible on their own bicycles connected to a magnetic brake. No differences in performance times were observed between the three trials (160.1 ± 4.1, 157.2 ± 4.5, and 159.8 ± 3.7 min, respectively). In trial B, plasma BCAA levels increased from 339 ± 28 μM at rest to 1,026 ± 62 μM after exercise ( P < 0.01). Plasma ammonia concentrations increased during the entire exercise period for all three trials and were significantly higher in trial B compared with trials G and P ( P< 0.05). The respiratory exchange ratio was similar in the three trials during the first 90 min of exercise; thereafter, it tended to drop more in trial P than in trials G and B. These data suggest that neither glucose nor glucose plus BCAA ingestion during 100 km of cycling enhance performance in well-trained cyclists.

Carbohydrates, Branched-Chain Amino Acids, and Endurances: The Central Fatigue Hypothesis

1995 ◽  
Vol 5 (s1) ◽  
pp. S29-S38 ◽  
Author(s):  
J. Mark Davis
Keyword(s):  
Amino Acids ◽  
Exercise Performance ◽  
Prolonged Exercise ◽  
Central Fatigue ◽  
Branched Chain Amino Acids ◽  
Convincing Evidence ◽  
Free Tryptophan ◽  
Branched Chain ◽  
Sport And Exercise ◽  
Exercise Induced

The mechanisms of central fatigue are largely unexplored, but the central fatigue hypothesis suggests that increased brain serotonin (5-HT) can cause a deterioration in sport and exercise performance. There is now convincing evidence that exercise-induced increases in the plasma free tryptophan (f-TRP)/branched-chain amino acids (BCCA) ratio are associated with increased brain 5-HT and the onset of fatigue during prolonged exercise. Furthermore, when drugs are administered to alter brain 5-HT, they have the predicted effects on exercise performance. The influence of nutritional manipulations of f-TRP/BCCA on performance is less well established. The effects of BCCA supplementation on exercise performance are mixed, and the published studies often suffer from methodological flaws. Alternatively, dramatic reductions in f-TRP/BCCA and enhanced performance accompany carbohydrate feedings during prolonged exercise. However, it is difficult to distinguish between the effects of carbohydrate feedings on mechanisms that reside in the brain versus the muscles themselves.

scholarly journals Comparative Effects of the Branched-Chain Amino Acids, Leucine, Isoleucine and Valine, on Gastric Emptying, Plasma Glucose, C-Peptide and Glucagon in Healthy Men

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1613
Author(s):  
Rachel A. Elovaris ◽  
Vida Bitarafan ◽  
Shahram Agah ◽  
Sina S. Ullrich ◽  
Kylie Lange ◽  
...  
Keyword(s):  
Amino Acids ◽  
Blood Glucose ◽  
Gastric Emptying ◽  
Plasma Glucose ◽  
Branched Chain Amino Acids ◽  
Postprandial Blood Glucose ◽  
Intragastric Administration ◽  
C Peptide ◽  
Healthy Men ◽  
Branched Chain

(1) Background: Whey protein lowers postprandial blood glucose in health and type 2 diabetes, by stimulating insulin and incretin hormone secretion and slowing gastric emptying. The branched-chain amino acids, leucine, isoleucine and valine, abundant in whey, may mediate the glucoregulatory effects of whey. We investigated the comparative effects of intragastric administration of leucine, isoleucine and valine on the plasma glucose, C-peptide and glucagon responses to and gastric emptying of a mixed-nutrient drink in healthy men. (2) Methods: 15 healthy men (27 ± 3 y) received, on four separate occasions, in double-blind, randomised fashion, either 10 g of leucine, 10 g of isoleucine, 10 g of valine or control, intragastrically, 30 min before a mixed-nutrient drink. Plasma glucose, C-peptide and glucagon concentrations were measured before, and for 2 h following, the drink. Gastric emptying of the drink was quantified using 13C-acetate breath-testing. (3) Results: Amino acids alone did not affect plasma glucose or C-peptide, while isoleucine and valine, but not leucine, stimulated glucagon (p < 0.05), compared with control. After the drink, isoleucine and leucine reduced peak plasma glucose compared with both control and valine (all p < 0.05). Neither amino acid affected early (t = 0–30 min) postprandial C-peptide or glucagon. While there was no effect on overall gastric emptying, plasma glucose at t = 30 min correlated with early gastric emptying (p < 0.05). (4) Conclusion: In healthy individuals, leucine and isoleucine lower postprandial blood glucose, at least in part by slowing gastric emptying, while valine does not appear to have an effect, possibly due to glucagon stimulation.

scholarly journals Branched-Chain Amino Acids and Central Fatigue

2006 ◽  
Vol 136 (1) ◽  
pp. 274S-276S ◽  
Author(s):  
Eric A. Newsholme ◽  
Eva Blomstrand
Keyword(s):  
Amino Acids ◽  
Central Fatigue ◽  
Branched Chain Amino Acids ◽  
Branched Chain
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