scholarly journals Clinical immunology Gene expression disorders of innate antibacterial signaling pathway in pancreatic cancer patients: implications for leukocyte dysfunction and tumor progression

2014 ◽  
Vol 4 ◽  
pp. 498-507 ◽  
Author(s):  
Robert Słotwiński ◽  
Aleksandra Dąbrowska ◽  
Gustaw Lech ◽  
Maciej Słodkowski ◽  
Sylwia M. Słotwińska
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Signaling Pathway ◽  
Clinical Immunology

scholarly journals Clinical immunology Glutamine abolishes the TLR4 gene expression levels in pancreatic cancer patients: a preliminary study

2012 ◽  
Vol 4 ◽  
pp. 350-354
Author(s):  
Sylwia Kędziora ◽  
Robert Słotwiński ◽  
Aleksandra Dąbrowska ◽  
Gustaw Lech ◽  
Maciej Słodkowski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Cancer Patients ◽  
Clinical Immunology ◽  
Expression Levels ◽  
Tlr4 Gene ◽  
Preliminary Study ◽  
Gene Expression Levels

Prognostic value of tumor progression-related gene expression in colorectal cancer patients

2012 ◽  
Vol 138 (10) ◽  
pp. 1631-1640 ◽  
Author(s):  
Miriam E. Uhlmann ◽  
Milka Georgieva ◽  
Martin Sill ◽  
Ulrich Linnemann ◽  
Martin R. Berger
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Related Gene ◽  
Colorectal Cancer Patients

scholarly journals Analysis of gene expression on ngn3 gene signaling pathway in endocrine pancreatic cancer

2013 ◽  
Vol 9 (14) ◽  
pp. 739-747
Author(s):  
Prashantha Nagaraja ◽  
◽  
Kavya Parashivamurthy ◽  
Nandini Sidnal ◽  
Siddappa Mali ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Signaling Pathway

scholarly journals Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Ronghua Zhang ◽  
Qiaofei Liu ◽  
Junya Peng ◽  
Mengyi Wang ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Signaling Pathway ◽  
In Vitro Study ◽  
Stat3 Signaling ◽  
Pancreatic Cancer Cells ◽  
Complement Dependent Cytotoxicity ◽  
Stat3 Signaling Pathway

Abstract Tumor-associated macrophages (TAMs) are versatile immune cells that promote a variety of malignant behaviors of pancreatic cancer. CD59 is a GPI-anchored membrane protein that prevents complement activation by inhibiting the formation of the membrane attack complex, which may protect cancer cells from complement-dependent cytotoxicity (CDC). The interactions between CD59, TAMs and pancreatic cancer remain largely unknown. A tissue microarray of pancreatic cancer patients was used to evaluate the interrelationship of CD59 and TAMs and their survival impacts were analyzed. In a coculture system, THP-1 cells were used as a model to study the function of TAMs and the roles of pancreatic cancer-educated macrophages in regulating the expression of CD59 in pancreatic cancer cells were demonstrated by real-time PCR, western blot and immunofluorescence staining. The effects of macrophages on regulating CDC in pancreatic cancer cells were demonstrated by an in vitro study. To explore the potential mechanisms, RNA sequencing of pancreatic cancer cells with or without co-culture of THP-1 macrophages was performed, and the results showed that the IL-6R/STAT3 signaling pathway might participate in the regulation, which was further demonstrated by target-siRNA transfection, antibody neutralization and STAT3 inhibitors. Our data revealed that the infiltration of TAMs and the expression of CD59 of pancreatic cancer were paralleled, and higher infiltration of TAMs and higher expression of CD59 predicted worse survival of pancreatic cancer patients. Pancreatic cancer-educated macrophages could protect cancer cells from CDC by up-regulating CD59 via the IL-6R/STAT3 signaling pathway. These findings uncovered the novel mechanisms between TAMs and CD59, and contribute to providing a new promising target for the immunotherapy of pancreatic cancer.

Abstract 3262: Notch signaling pathway-targeted therapy suppresses tumor progression and prevents metastatic spread in pancreatic cancer

2012 ◽  
Author(s):  
Shinichi Yabuuchi ◽  
Roeland F. de Wilde ◽  
Nathaniel Campbell ◽  
Elizabeth De Oliveira ◽  
Zeshaan Rasheed ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Targeted Therapy ◽  
Tumor Progression ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
Metastatic Spread

Impact of deregulation of the gene expression of hedgehog signaling pathway in resectable pancreatic cancer

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S59
Author(s):  
Beatrice Mohelnikova-Duchonova ◽  
Veronika Brynychova ◽  
Martin Oliverius ◽  
Jan Hlavsa ◽  
Eva Honsova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Resectable Pancreatic Cancer

scholarly journals DNA Methylation and Gene Expression with Clinical Covariates Explain Variation in Aggressiveness and Survival of Pancreatic Cancer Patients

2020 ◽  
Vol 38 (8-9) ◽  
pp. 502-506
Author(s):  
Shyamali Mukerjee ◽  
Agustin Gonzalez-Reymundez ◽  
Sophia Y. Lunt ◽  
Ana I. Vazquez
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Clinical Covariates
Sign in / Sign up

Export Citation Format

Share Document