scholarly journals Minor allele of rs12976445 polymorphism in the promoter region of microRNA-125a is associated with the severity of primary open-angle glaucoma (POAG)

2021 ◽  
Author(s):  
Wenjia Zhang ◽  
Yan Li ◽  
Hongqin Ke ◽  
Yingting Wang ◽  
Cong Duan ◽  
...  
Keyword(s):  
Promoter Region ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Demographic Characteristics ◽  
U937 Cells ◽  
Open Angle ◽  
Blood Samples ◽  
Downstream Target ◽  
Protein Levels ◽  
The Relationship

IntroductionThe signaling pathway of IL-6 has been reported to be associated with the severity of glaucoma. And the rs12976445 SNP in miR-125 could alter the expression of miR-125, which is directly targeted by IL-6R.Material and methodsIn this study, we recruited 88 POAG patients and grouped them according to their genotype of rs12976445 as GG group, GC group and CC group to study the association between the miR-125a polymorphism and POAG. We collected demographic characteristics and peripheral blood samples from 88 subjects. Then, rs12976445 genotypes in these subjects were determined to evaluate their relationship with the POAG index. THP-1 and U937 cells were transfected with miR-125a mimic or IL-6R siRNA to assess the relationship between miR-125a and IL-6R/ACHE.ResultsIL-6R is a downstream target of miR-125a and the overexpression of miR-125a showed significantly decreased mRNA and protein levels of IL-6R. The expression levels of miR-125a were the highest in the GG group and the lowest in the CC group, while the activity of IL-6 was comparable in the three groups. Moreover, the mRNA and protein levels of IL-6R were the lowest in the GG group and the highest in the CC group. Additionally, significantly thinner RNFL, larger average cup disc ratio, larger vertical cup disc ratio, and depressed visual field were observed in POAG patients carrying the CC genotype.ConclusionsIn summary, our data suggested that the rs12976445 polymorphism was significantly associated with the risk of POAG.

Biomechanics of Glaucoma: A Parametric Study of Flow in Schlemm’s Canal

2009 ◽  
Author(s):  
Carolyn Stolfi ◽  
Jenn S. Rossmann
Keyword(s):  
Intraocular Pressure ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Outflow Resistance ◽  
Governing Equations ◽  
Common Causes ◽  
Tissue Porosity ◽  
Realistic Geometries ◽  
The Relationship

Glaucoma is one of the most common causes of blindness, affecting approximately seventy million people. Glaucoma is typically caused by high intraocular pressures due to increased outflow resistance, which is primarily concentrated within the trabeculae meshwork and the canal of Schlemm. Debris within trabecular spaces can complicate and limit formation and reabsorption of aqueous humor, leading to elevated interocular pressures. In this study, the biomechanics of Primary Open-Angle Glaucoma are investigated. Computational modeling in physiologically realistic geometries is performed to examine the relationship between intraocular pressure and downstream trabecular and canal resistance. The governing equations for fluid flow are solved, and the influence of such factors as tissue porosity is evaluated. Increased understanding of the biomechanics of glaucoma can improve diagnosis and treatment of this disease.

scholarly journals Antiglaucoma medication utilization and therapeutic outcome among Nigerian older persons with primary open angle glaucoma

2019 ◽  
Vol 19 (1) ◽  
pp. 141-147
Author(s):  
SA Saka ◽  
BO Onyeukwu ◽  
UIH Eze
Keyword(s):  
Logistic Regression ◽  
Medication Adherence ◽  
Older Persons ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Medical Science ◽  
Therapeutic Outcome ◽  
University Teaching ◽  
Open Angle ◽  
The Relationship

Background: Primary open angle glaucoma (POAG) is associated with older age. Antiglaucoma medications (AGM) are the cornerstones in the management of POAG. However, the relationship between AGM utilization, patients’ medication adherence (MA) and the therapeutic outcome remains largely unexplored among older persons. Objective: This study aimed to evaluate AGM utilization patterns, patients’ MA and intraocular pressure (IOP) reduction among older persons. Methods: This study was a 5-year retrospective review of medical records of consecutively selected older persons diagnosed of POAG at a University teaching hospital, in southwest Nigeria. Older persons were included if (1) aged 65 years and above, (2) had attended the outpatient ophthalmic clinics of the hospital between January 2010 and December 2015 (3) had at least 1-year clinic attendance during the period. The relationship between AGM utilization, patients’ self-reported MA and physicians’ comments on IOP was evaluated. A bivariate analysis was carried out to determine associations between variables and MA. Factors associated with IOP reduction were determined using a logistic regression. p<0.05 was considered statistically significant. Results: The carbonic anhydrase inhibitors comprised (66/191; 34.6%) of the total 191 AGM prescriptions. Majority of the participants (36/60; 60.0%) had reduced IOP with AGM alone, of which (13/36;36.1%) were on triple AGM. The participants’ MA (p=0.01) and number of AGM (p=0.04) were significantly associated with IOP reduction among the participants in a logistic regression. Conclusion: The number of AGM prescribed and the patients’ medication adherence can influence IOP reduction among older persons with POAG. Bangladesh Journal of Medical Science Vol.19(1) 2020 p.141-147

scholarly journals Evaluation of Redox Profiles of the Serum and Aqueous Humor in Patients with Primary Open-Angle Glaucoma and Exfoliation Glaucoma

Antioxidants ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1305
Author(s):  
Yuji Takayanagi ◽  
Yasuyuki Takai ◽  
Sachiko Kaidzu ◽  
Masaki Tanito
Keyword(s):  
Oxidative Stress ◽  
Aqueous Humor ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Lipid Peroxides ◽  
Redox Status ◽  
Reactive Oxygen Metabolites ◽  
Open Angle ◽  
Blood Samples ◽  
Exfoliation Glaucoma

Oxidative stress is thought to play a significant role in the development of glaucoma. However, the association between systemic and local oxidative stresses in different types of glaucoma has not been assessed fully. The current study compared the redox status in the aqueous humor (AH) and blood samples among eyes with primary open-angle glaucoma (POAG), exfoliation glaucoma (EXG), and non-glaucomatous controls to evaluate the relationship among systemic redox status, intraocular oxidative stress, and clinical backgrounds. AH and blood samples were obtained from 45 eyes of 45 Japanese subjects (15 POAG, 15 EXG, and 15 control eyes). The serum levels of lipid peroxides, ferric-reducing activity, and thiol antioxidant activity were measured by diacron reactive oxygen metabolites (dROM), biologic antioxidant potential (BAP), and sulfhydryl (SH) tests, respectively, using a free radical analyzer. The activities of cytosolic and mitochondrial forms of the superoxide dismutase (SOD) isoforms, i.e., SOD1 and SOD2, respectively, in AH and serum were measured using a multiplex bead immunoassay. In AH, SOD1 in subjects with EXG and SOD2 in those with POAG and EXG were significantly higher than in control eyes. In serum, compared to control subjects, BAP in subjects with POAG and EXG was significantly lower; SOD1 in those with EXG and SOD2 in those with POAG and EXG were significantly higher. dROM and SH did not differ significantly among the groups. The BAP values were correlated negatively with the SOD1 concentrations in AH and serum, SOD2 in the AH, intraocular pressure, and number of antiglaucoma medications. In conclusion, lower systemic antioxidant capacity accompanies up-regulation of higher local antioxidant enzymes, suggesting increased oxidative stress in eyes with OAG, especially in EXG. Determination of the systemic BAP values may help predict the redox status in AH.

The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle glaucoma

2018 ◽  
Vol 39 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Mateusz Siwak ◽  
Marcin Maślankiewicz ◽  
Alicja Nowak-Zduńczyk ◽  
Wioletta Rozpędek ◽  
Radosław Wojtczak ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Expression Levels ◽  
Genes Expression ◽  
The Relationship

scholarly journals Sleep-disordered breathing a neglected risk factor in primary open-angle glaucoma

2021 ◽  
Vol 6 (4) ◽  
pp. 76-84
Author(s):  
Dr. Mandeep Kaur ◽  
◽  
Dr. Inderjit Kaur ◽  
Dr. Jagdeepak Singh ◽  
◽  
...  
Keyword(s):  
Risk Factor ◽  
Sleep Disordered Breathing ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
P Value ◽  
Open Angle ◽  
Male Predominance ◽  
Associated Risk Factors ◽  
The Relationship ◽  
Disordered Breathing

Background: Sleep-disordered breathing (SDB) is accompanied by large swings in blood pressureand the repetitive hypoxic period during sleep, which may accelerate anoxic optic nerve damageseen in glaucoma. There are many associated risk factors in primary open-angle glaucoma (POAG),but recently, SDB, though a neglected one, is coming up as a risk factor. However, various studieshave reported controversial findings. Objective: To evaluate the relationship between SDB andPOAG. Design: A hospital-based case-control study. Methods: A total of 400 patients between 30–70 years were recruited from eye OPD between 2008- 2010. They were divided into two groups, 200cases with established POAG and 200 age and sex-matched healthy subjects with normal IOP in thecontrol group. Detailed history, complete ophthalmic and ENT examination was made along withBMI, blood pressure and neck girth measurement. Both groups were interviewed with aquestionnaire regarding SDB and were recorded on the Epworth sleepiness scale (ESS). Results:The mean age being 55.02 ± 8.66 in the POAG group and male predominance noted both in POAGand SDB patients with ESS> 10 was statistically significant (p < 0.05). Also, patients in the POAGgroup with ESS > 10 had more IOP and BMI, greater neck girth, high BP and more ENT problemswith p-value < 0,001, which is highly significant, thus showing the relationship between SDB andPOAG. Conclusions: Increased community awareness and earlier detection of glaucoma and itscorrelation with SDB results in decreased morbidity.

scholarly journals The relationship of TP53 and GRIN2B gene polymorphisms with risk of occurrence and progression of primary open-angle glaucoma in a Polish population

2014 ◽  
Vol 4 ◽  
pp. 313-321 ◽  
Author(s):  
Alicja Nowak ◽  
Karolina Przybylowska-Sygut ◽  
Katarzyna Szymanek ◽  
Jerzy Szaflik ◽  
Jacek P. Szaflik ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Polish Population ◽  
Open Angle ◽  
Relationship Of ◽  
The Relationship
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